Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386697030> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4386697030 endingPage "117185" @default.
- W4386697030 startingPage "117185" @default.
- W4386697030 abstract "Cymbopogon jwarancusa (Jones) Schult. (Family: Poacea/Gramineae) is being used to treat numerous ailments in traditional/folklore and indigenous system of medicine due to its antioxidant, anti-allergic, antiparasitic, analgesic, antipyretic and anticancer activities; however there is no documented evidence regarding its hepatoprotective efficacy.This study was aimed to evaluate hepatoprotective activity of hydroalcoholic extract of Cymbopogon jwarancusa (HECJ) against paracetamol (PCM) induced liver damage in albino Wistar rats, and to identify the bioactive components present in the extract responsible for the said activity.Five groups of rats (n = 6) were orally treated with: 0.5% carboxymethyl cellulose (normal control), 50 mg/kg silymarin (reference standard), HECJ [515 mg/kg (low dose) and 720 mg/kg (high dose)] (test groups) for 7 days daily, followed by induction of hepato-toxicity using PCM (2 gm/kg) on 7th day (PCM control; reference standard; test groups). The blood samples to estimate the level of AST, ALT, ALP, total bilirubin and total protein; liver tissue homogenate for antioxidant markers (GSH, GST, GPx, and LPO) and liver section for histopathological analysis were collected. Isolation and characterization of phytochemicals from HECJ was done by preliminary screening, determination of phenolic, flavonoid and terpenoid content, and GC-MS analysis.The animals pre-treated with HECJ dose-dependently and significantly alleviated the PCM-induced alterations in liver enzymes, plasma proteins, serum total bilirubin and antioxidant markers levels. The histopathological analysis suggest that PCM causes marked necrosis and lymphocyte infiltration, while preservation of the normal hepatic architecture was observed in groups pre-treated with, reference standard drug silymarin, and HECJ. Preliminary screening of the extract, determination of phenolic, flavonoid and terpenoid content, and GC-MS analysis revealed the presence of some important bioactive components such as phenolics, flavonoids, glycoside, tannins, steroids, fatty acids, sterols, esters, saponins, terpenes/terpenoids and essential oil which could be synergistically responsible for the plant's hepatoprotective effect.This study concluded that C. jwarancusa could be taken as a beneficial natural product for its hepatoprotective efficacy; however, future line of work is required to establish its precise mechanism of action." @default.
- W4386697030 created "2023-09-14" @default.
- W4386697030 creator A5006087744 @default.
- W4386697030 creator A5022804821 @default.
- W4386697030 creator A5031208764 @default.
- W4386697030 creator A5032330040 @default.
- W4386697030 creator A5067208952 @default.
- W4386697030 creator A5081706140 @default.
- W4386697030 date "2024-01-01" @default.
- W4386697030 modified "2023-09-27" @default.
- W4386697030 title "Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity" @default.
- W4386697030 cites W1513495951 @default.
- W4386697030 cites W1527821398 @default.
- W4386697030 cites W1581414347 @default.
- W4386697030 cites W1608114173 @default.
- W4386697030 cites W1677870197 @default.
- W4386697030 cites W1990739062 @default.
- W4386697030 cites W2033763740 @default.
- W4386697030 cites W2053054955 @default.
- W4386697030 cites W2091789540 @default.
- W4386697030 cites W2118909190 @default.
- W4386697030 cites W2129070184 @default.
- W4386697030 cites W2151770012 @default.
- W4386697030 cites W2290311699 @default.
- W4386697030 cites W2290466312 @default.
- W4386697030 cites W2335050049 @default.
- W4386697030 cites W2523125049 @default.
- W4386697030 cites W2535848663 @default.
- W4386697030 cites W2561274954 @default.
- W4386697030 cites W2811069251 @default.
- W4386697030 cites W2884944140 @default.
- W4386697030 cites W2981777668 @default.
- W4386697030 cites W3014293228 @default.
- W4386697030 cites W3036965820 @default.
- W4386697030 cites W3039041926 @default.
- W4386697030 cites W3087011070 @default.
- W4386697030 cites W3097558047 @default.
- W4386697030 cites W3165988702 @default.
- W4386697030 cites W3203761087 @default.
- W4386697030 cites W4200232992 @default.
- W4386697030 cites W4210429357 @default.
- W4386697030 cites W4223465522 @default.
- W4386697030 cites W4281746308 @default.
- W4386697030 cites W4292677799 @default.
- W4386697030 cites W4293247451 @default.
- W4386697030 cites W4318499034 @default.
- W4386697030 doi "https://doi.org/10.1016/j.jep.2023.117185" @default.
- W4386697030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37714225" @default.
- W4386697030 hasPublicationYear "2024" @default.
- W4386697030 type Work @default.
- W4386697030 citedByCount "0" @default.
- W4386697030 crossrefType "journal-article" @default.
- W4386697030 hasAuthorship W4386697030A5006087744 @default.
- W4386697030 hasAuthorship W4386697030A5022804821 @default.
- W4386697030 hasAuthorship W4386697030A5031208764 @default.
- W4386697030 hasAuthorship W4386697030A5032330040 @default.
- W4386697030 hasAuthorship W4386697030A5067208952 @default.
- W4386697030 hasAuthorship W4386697030A5081706140 @default.
- W4386697030 hasConcept C185592680 @default.
- W4386697030 hasConcept C2777513400 @default.
- W4386697030 hasConcept C2778004101 @default.
- W4386697030 hasConcept C2779252780 @default.
- W4386697030 hasConcept C2780820201 @default.
- W4386697030 hasConcept C2781401929 @default.
- W4386697030 hasConcept C55493867 @default.
- W4386697030 hasConcept C556039675 @default.
- W4386697030 hasConcept C71924100 @default.
- W4386697030 hasConcept C90924648 @default.
- W4386697030 hasConcept C98274493 @default.
- W4386697030 hasConceptScore W4386697030C185592680 @default.
- W4386697030 hasConceptScore W4386697030C2777513400 @default.
- W4386697030 hasConceptScore W4386697030C2778004101 @default.
- W4386697030 hasConceptScore W4386697030C2779252780 @default.
- W4386697030 hasConceptScore W4386697030C2780820201 @default.
- W4386697030 hasConceptScore W4386697030C2781401929 @default.
- W4386697030 hasConceptScore W4386697030C55493867 @default.
- W4386697030 hasConceptScore W4386697030C556039675 @default.
- W4386697030 hasConceptScore W4386697030C71924100 @default.
- W4386697030 hasConceptScore W4386697030C90924648 @default.
- W4386697030 hasConceptScore W4386697030C98274493 @default.
- W4386697030 hasLocation W43866970301 @default.
- W4386697030 hasLocation W43866970302 @default.
- W4386697030 hasOpenAccess W4386697030 @default.
- W4386697030 hasPrimaryLocation W43866970301 @default.
- W4386697030 hasRelatedWork W2184358985 @default.
- W4386697030 hasRelatedWork W2316553702 @default.
- W4386697030 hasRelatedWork W2617523712 @default.
- W4386697030 hasRelatedWork W2622846185 @default.
- W4386697030 hasRelatedWork W2748952813 @default.
- W4386697030 hasRelatedWork W2764841094 @default.
- W4386697030 hasRelatedWork W2899084033 @default.
- W4386697030 hasRelatedWork W3012374757 @default.
- W4386697030 hasRelatedWork W3201432627 @default.
- W4386697030 hasRelatedWork W3046302942 @default.
- W4386697030 hasVolume "319" @default.
- W4386697030 isParatext "false" @default.
- W4386697030 isRetracted "false" @default.
- W4386697030 workType "article" @default.