Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386697032> ?p ?o ?g. }
- W4386697032 abstract "Many microRNAs (miRNAs) are characteristically found in cancer cells, making miRNAs promising marker biomolecules for cancer diagnosis and therapeutics. However, it is challenging to use miRNA as a cancer signature because it is difficult to convert the nucleic acid sequence information into molecular functionality. To address this challenge, we realize nucleic acid-to-small molecule converters using hairpin DNA circuits. Harnessing a Staudinger reduction as a trigger for the conversion, we constructed hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA) circuits that respond to oncogenic miR-21. Fluorophore and dye molecules were released in response to miR-21 through the HCR, providing fluorogenic and chromogenic readouts. Selective cytotoxicity in miR-21-abundant cells was realized by the CHA to release the anticancer drug SN-38. This would be the first example of selective activation of a small-molecule prodrug triggered by oncogenic miRNA in human living cells." @default.
- W4386697032 created "2023-09-14" @default.
- W4386697032 creator A5013305676 @default.
- W4386697032 creator A5039144618 @default.
- W4386697032 creator A5040606741 @default.
- W4386697032 creator A5058797631 @default.
- W4386697032 creator A5059322840 @default.
- W4386697032 date "2023-09-26" @default.
- W4386697032 modified "2023-10-16" @default.
- W4386697032 title "Nucleic Acid‐to‐Small Molecule Converter through Amplified Hairpin DNA Circuits" @default.
- W4386697032 cites W1522716087 @default.
- W4386697032 cites W1617520624 @default.
- W4386697032 cites W1945627170 @default.
- W4386697032 cites W1970839682 @default.
- W4386697032 cites W1977312644 @default.
- W4386697032 cites W1983305804 @default.
- W4386697032 cites W1989020100 @default.
- W4386697032 cites W1994645903 @default.
- W4386697032 cites W2000930736 @default.
- W4386697032 cites W2029430968 @default.
- W4386697032 cites W2043582897 @default.
- W4386697032 cites W2044505331 @default.
- W4386697032 cites W2045898351 @default.
- W4386697032 cites W2050630660 @default.
- W4386697032 cites W2052875990 @default.
- W4386697032 cites W2054711478 @default.
- W4386697032 cites W2054770710 @default.
- W4386697032 cites W2063892108 @default.
- W4386697032 cites W2085824528 @default.
- W4386697032 cites W2102699655 @default.
- W4386697032 cites W2107366413 @default.
- W4386697032 cites W2110919263 @default.
- W4386697032 cites W2111128506 @default.
- W4386697032 cites W2134409042 @default.
- W4386697032 cites W2135932388 @default.
- W4386697032 cites W2146046635 @default.
- W4386697032 cites W2148304424 @default.
- W4386697032 cites W2154097974 @default.
- W4386697032 cites W2162691613 @default.
- W4386697032 cites W2274448185 @default.
- W4386697032 cites W2282549937 @default.
- W4386697032 cites W2314146565 @default.
- W4386697032 cites W2486390728 @default.
- W4386697032 cites W2530773901 @default.
- W4386697032 cites W2558217333 @default.
- W4386697032 cites W2601848641 @default.
- W4386697032 cites W2618853121 @default.
- W4386697032 cites W2620625960 @default.
- W4386697032 cites W2735206325 @default.
- W4386697032 cites W2737895881 @default.
- W4386697032 cites W2758801079 @default.
- W4386697032 cites W2804062326 @default.
- W4386697032 cites W2817461677 @default.
- W4386697032 cites W2912988494 @default.
- W4386697032 cites W2973226654 @default.
- W4386697032 cites W2974428028 @default.
- W4386697032 cites W2996691528 @default.
- W4386697032 cites W3005351683 @default.
- W4386697032 cites W3016233583 @default.
- W4386697032 cites W3194403356 @default.
- W4386697032 cites W3210000153 @default.
- W4386697032 cites W4283793854 @default.
- W4386697032 cites W4312018969 @default.
- W4386697032 doi "https://doi.org/10.1002/anie.202306587" @default.
- W4386697032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37704581" @default.
- W4386697032 hasPublicationYear "2023" @default.
- W4386697032 type Work @default.
- W4386697032 citedByCount "0" @default.
- W4386697032 crossrefType "journal-article" @default.
- W4386697032 hasAuthorship W4386697032A5013305676 @default.
- W4386697032 hasAuthorship W4386697032A5039144618 @default.
- W4386697032 hasAuthorship W4386697032A5040606741 @default.
- W4386697032 hasAuthorship W4386697032A5058797631 @default.
- W4386697032 hasAuthorship W4386697032A5059322840 @default.
- W4386697032 hasBestOaLocation W43866970321 @default.
- W4386697032 hasConcept C104317684 @default.
- W4386697032 hasConcept C108215921 @default.
- W4386697032 hasConcept C129312508 @default.
- W4386697032 hasConcept C145059251 @default.
- W4386697032 hasConcept C161624437 @default.
- W4386697032 hasConcept C185592680 @default.
- W4386697032 hasConcept C21951064 @default.
- W4386697032 hasConcept C24107716 @default.
- W4386697032 hasConcept C49853544 @default.
- W4386697032 hasConcept C552990157 @default.
- W4386697032 hasConcept C55493867 @default.
- W4386697032 hasConcept C70721500 @default.
- W4386697032 hasConcept C86803240 @default.
- W4386697032 hasConceptScore W4386697032C104317684 @default.
- W4386697032 hasConceptScore W4386697032C108215921 @default.
- W4386697032 hasConceptScore W4386697032C129312508 @default.
- W4386697032 hasConceptScore W4386697032C145059251 @default.
- W4386697032 hasConceptScore W4386697032C161624437 @default.
- W4386697032 hasConceptScore W4386697032C185592680 @default.
- W4386697032 hasConceptScore W4386697032C21951064 @default.
- W4386697032 hasConceptScore W4386697032C24107716 @default.
- W4386697032 hasConceptScore W4386697032C49853544 @default.
- W4386697032 hasConceptScore W4386697032C552990157 @default.
- W4386697032 hasConceptScore W4386697032C55493867 @default.
- W4386697032 hasConceptScore W4386697032C70721500 @default.