FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386697551> ?p ?o ?g. }

• W4386697551 abstract "DNA damage response (DDR) pathways are essential to sustain genomic stability and play a critical role in cancer development and progression. Here, we investigated the profile of DDR gene mutations in early-stage non-small cell lung cancer (NSCLC) and their prognostic values.We first examined 74 DDR genes involved in seven DDR pathways and then focused on six specific genes: ATM, BRCA1, BRCA2, CHEK1, BARD1, and BRIP1. A total of 179 stage I and IIIa NSCLC patients who received curative resection in Peking Union Medical College Hospital and their corresponding samples were collected for DNA sequencing, immunohistochemistry and survival analysis.A total of 167 eligible patients were finally analyzed. Mutation frequencies were 82% and 26.3% for the selected 74 genes and six genes, respectively. Mismatch repair (MMR) and nucleotide excision repair (NER) alterations were observed more frequently in lung squamous cell carcinoma (LUSC) and smokers were more likely to develop the selected six DDR gene mutations than those who never smoked. Deleterious mutations in the six genes were independent prognostic indicators of significantly longer disease-free survival and overall survival. No association was found between DDR gene status and PD-L1 expression, CD8 positive lymphocyte and tumor-associated macrophage infiltration in tumor area. However, numbers of mutations were significantly increased among patients with DDR alterations.Deleterious mutations of these six genes were common in resected NSCLC and could serve as prognostic biomarkers." @default.
• W4386697551 created "2023-09-14" @default.
• W4386697551 creator A5004349988 @default.
• W4386697551 creator A5007935580 @default.
• W4386697551 creator A5032130456 @default.
• W4386697551 creator A5043365458 @default.
• W4386697551 creator A5064887006 @default.
• W4386697551 creator A5065277236 @default.
• W4386697551 creator A5065380119 @default.
• W4386697551 creator A5074410204 @default.
• W4386697551 creator A5079400235 @default.
• W4386697551 creator A5090482004 @default.
• W4386697551 date "2023-09-13" @default.
• W4386697551 modified "2023-09-27" @default.
• W4386697551 title "Clinical significance of <scp>DNA</scp> damage response mutations in stage I and stage <scp>IIIa NSCLC</scp>" @default.
• W4386697551 cites W2077436902 @default.
• W4386697551 cites W2130177169 @default.
• W4386697551 cites W2165385395 @default.
• W4386697551 cites W2166580271 @default.
• W4386697551 cites W2228221433 @default.
• W4386697551 cites W2527992063 @default.
• W4386697551 cites W2581231749 @default.
• W4386697551 cites W2788431960 @default.
• W4386697551 cites W2892173355 @default.
• W4386697551 cites W2893501833 @default.
• W4386697551 cites W2910873889 @default.
• W4386697551 cites W2912003906 @default.
• W4386697551 cites W2946329325 @default.
• W4386697551 cites W2949694992 @default.
• W4386697551 cites W3020255857 @default.
• W4386697551 cites W3020771563 @default.
• W4386697551 cites W3041475851 @default.
• W4386697551 cites W3041829178 @default.
• W4386697551 cites W3081329969 @default.
• W4386697551 cites W3082106558 @default.
• W4386697551 cites W3088951995 @default.
• W4386697551 cites W3110960712 @default.
• W4386697551 cites W3119005666 @default.
• W4386697551 cites W3119518737 @default.
• W4386697551 cites W3131014490 @default.
• W4386697551 cites W3171197344 @default.
• W4386697551 cites W3187644677 @default.
• W4386697551 cites W3199354869 @default.
• W4386697551 cites W3203615203 @default.
• W4386697551 cites W3217378264 @default.
• W4386697551 cites W4280495239 @default.
• W4386697551 cites W4291020085 @default.
• W4386697551 cites W4293182132 @default.
• W4386697551 doi "https://doi.org/10.1111/1759-7714.15109" @default.
• W4386697551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37704455" @default.
• W4386697551 hasPublicationYear "2023" @default.
• W4386697551 type Work @default.
• W4386697551 citedByCount "0" @default.
• W4386697551 crossrefType "journal-article" @default.
• W4386697551 hasAuthorship W4386697551A5004349988 @default.
• W4386697551 hasAuthorship W4386697551A5007935580 @default.
• W4386697551 hasAuthorship W4386697551A5032130456 @default.
• W4386697551 hasAuthorship W4386697551A5043365458 @default.
• W4386697551 hasAuthorship W4386697551A5064887006 @default.
• W4386697551 hasAuthorship W4386697551A5065277236 @default.
• W4386697551 hasAuthorship W4386697551A5065380119 @default.
• W4386697551 hasAuthorship W4386697551A5074410204 @default.
• W4386697551 hasAuthorship W4386697551A5079400235 @default.
• W4386697551 hasAuthorship W4386697551A5090482004 @default.
• W4386697551 hasBestOaLocation W43866975511 @default.
• W4386697551 hasConcept C104317684 @default.
• W4386697551 hasConcept C104451858 @default.
• W4386697551 hasConcept C126322002 @default.
• W4386697551 hasConcept C134935766 @default.
• W4386697551 hasConcept C143998085 @default.
• W4386697551 hasConcept C146357865 @default.
• W4386697551 hasConcept C151730666 @default.
• W4386697551 hasConcept C2776256026 @default.
• W4386697551 hasConcept C501734568 @default.
• W4386697551 hasConcept C502942594 @default.
• W4386697551 hasConcept C54355233 @default.
• W4386697551 hasConcept C71924100 @default.
• W4386697551 hasConcept C86803240 @default.
• W4386697551 hasConceptScore W4386697551C104317684 @default.
• W4386697551 hasConceptScore W4386697551C104451858 @default.
• W4386697551 hasConceptScore W4386697551C126322002 @default.
• W4386697551 hasConceptScore W4386697551C134935766 @default.
• W4386697551 hasConceptScore W4386697551C143998085 @default.
• W4386697551 hasConceptScore W4386697551C146357865 @default.
• W4386697551 hasConceptScore W4386697551C151730666 @default.
• W4386697551 hasConceptScore W4386697551C2776256026 @default.
• W4386697551 hasConceptScore W4386697551C501734568 @default.
• W4386697551 hasConceptScore W4386697551C502942594 @default.
• W4386697551 hasConceptScore W4386697551C54355233 @default.
• W4386697551 hasConceptScore W4386697551C71924100 @default.
• W4386697551 hasConceptScore W4386697551C86803240 @default.
• W4386697551 hasLocation W43866975511 @default.
• W4386697551 hasLocation W43866975512 @default.
• W4386697551 hasOpenAccess W4386697551 @default.
• W4386697551 hasPrimaryLocation W43866975511 @default.
• W4386697551 hasRelatedWork W1953277120 @default.
• W4386697551 hasRelatedWork W1992872815 @default.
• W4386697551 hasRelatedWork W2028001901 @default.
• W4386697551 hasRelatedWork W2032912323 @default.
• W4386697551 hasRelatedWork W2062763504 @default.

• next