Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386699208> ?p ?o ?g. }
- W4386699208 abstract "Increasing evidence suggests that reactive astrocytes are associated with Alzheimer's disease (AD). However, its underlying pathogenesis remains unknown. Given the role of astrocytes in energy metabolism, reactive astrocytes may contribute to altered brain energy metabolism. Astrocytes are primarily considered glycolytic cells, suggesting a preference for lactate production. This study aimed to examine alterations in astrocytic activities and their association with brain lactate levels in AD.The study included 30 AD and 30 cognitively unimpaired participants. For AD participants, amyloid and tau depositions were confirmed by positron emission tomography using [11 C]PiB and [18 F]florzolotau, respectively. Myo-inositol, an astroglial marker, and lactate in the posterior cingulate cortex were quantified by magnetic resonance spectroscopy. These magnetic resonance spectroscopy metabolites were compared with plasma biomarkers, including glial fibrillary acidic protein as another astrocytic marker, and amyloid and tau positron emission tomography.Myo-inositol and lactate levels were higher in AD patients than in cognitively unimpaired participants (p < 0.05). Myo-inositol levels correlated with lactate levels (r = 0.272, p = 0.047). Myo-inositol and lactate levels were positively associated with the Clinical Dementia Rating sum-of-boxes scores (p < 0.05). Significant correlations were noted between myo-inositol levels and plasma glial fibrillary acidic protein, tau phosphorylated at threonine 181 levels, and amyloid and tau positron emission tomography accumulation in the posterior cingulate cortex (p < 0.05).We found high myo-inositol levels accompanied by increased lactate levels in the posterior cingulate cortex in AD patients, indicating a link between reactive astrocytes and altered brain energy metabolism. Myo-inositol and plasma glial fibrillary acidic protein may reflect similar astrocytic changes as biomarkers of AD. ANN NEUROL 2023." @default.
- W4386699208 created "2023-09-14" @default.
- W4386699208 creator A5002819177 @default.
- W4386699208 creator A5005900519 @default.
- W4386699208 creator A5007634667 @default.
- W4386699208 creator A5007656861 @default.
- W4386699208 creator A5009387560 @default.
- W4386699208 creator A5009790212 @default.
- W4386699208 creator A5018565112 @default.
- W4386699208 creator A5030087345 @default.
- W4386699208 creator A5030217409 @default.
- W4386699208 creator A5030948491 @default.
- W4386699208 creator A5036721496 @default.
- W4386699208 creator A5044523491 @default.
- W4386699208 creator A5048387675 @default.
- W4386699208 creator A5064403117 @default.
- W4386699208 creator A5068849863 @default.
- W4386699208 creator A5068994256 @default.
- W4386699208 creator A5069308721 @default.
- W4386699208 creator A5073327869 @default.
- W4386699208 creator A5079225739 @default.
- W4386699208 creator A5089307173 @default.
- W4386699208 date "2023-09-28" @default.
- W4386699208 modified "2023-10-13" @default.
- W4386699208 title "Altered brain energy metabolism related to astrocytes in Alzheimer's disease" @default.
- W4386699208 cites W1557128794 @default.
- W4386699208 cites W1797578063 @default.
- W4386699208 cites W1901260206 @default.
- W4386699208 cites W1972205560 @default.
- W4386699208 cites W1980361506 @default.
- W4386699208 cites W2001618696 @default.
- W4386699208 cites W2002559713 @default.
- W4386699208 cites W2023798788 @default.
- W4386699208 cites W2038979894 @default.
- W4386699208 cites W2046429594 @default.
- W4386699208 cites W2054163710 @default.
- W4386699208 cites W2092635505 @default.
- W4386699208 cites W2099292814 @default.
- W4386699208 cites W2108474398 @default.
- W4386699208 cites W2127421809 @default.
- W4386699208 cites W2130943278 @default.
- W4386699208 cites W2156220037 @default.
- W4386699208 cites W2159122349 @default.
- W4386699208 cites W2178869124 @default.
- W4386699208 cites W2279193171 @default.
- W4386699208 cites W2297872912 @default.
- W4386699208 cites W2317490759 @default.
- W4386699208 cites W2510994186 @default.
- W4386699208 cites W2558272519 @default.
- W4386699208 cites W2560999412 @default.
- W4386699208 cites W2584889633 @default.
- W4386699208 cites W2750075274 @default.
- W4386699208 cites W2791328144 @default.
- W4386699208 cites W2810124976 @default.
- W4386699208 cites W2883274417 @default.
- W4386699208 cites W2899413413 @default.
- W4386699208 cites W2905362030 @default.
- W4386699208 cites W2915859536 @default.
- W4386699208 cites W2932841619 @default.
- W4386699208 cites W2977177663 @default.
- W4386699208 cites W2994918891 @default.
- W4386699208 cites W2999818394 @default.
- W4386699208 cites W3009746164 @default.
- W4386699208 cites W3015916968 @default.
- W4386699208 cites W3029234273 @default.
- W4386699208 cites W3097325346 @default.
- W4386699208 cites W3108081750 @default.
- W4386699208 cites W3131288202 @default.
- W4386699208 cites W3132240972 @default.
- W4386699208 cites W3135516129 @default.
- W4386699208 cites W4205631786 @default.
- W4386699208 cites W4205687010 @default.
- W4386699208 cites W4205976963 @default.
- W4386699208 cites W4206174876 @default.
- W4386699208 cites W4210281487 @default.
- W4386699208 cites W4224885869 @default.
- W4386699208 cites W4225532492 @default.
- W4386699208 cites W4281257092 @default.
- W4386699208 cites W4310461604 @default.
- W4386699208 cites W4311172803 @default.
- W4386699208 doi "https://doi.org/10.1002/ana.26797" @default.
- W4386699208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37703428" @default.
- W4386699208 hasPublicationYear "2023" @default.
- W4386699208 type Work @default.
- W4386699208 citedByCount "0" @default.
- W4386699208 crossrefType "journal-article" @default.
- W4386699208 hasAuthorship W4386699208A5002819177 @default.
- W4386699208 hasAuthorship W4386699208A5005900519 @default.
- W4386699208 hasAuthorship W4386699208A5007634667 @default.
- W4386699208 hasAuthorship W4386699208A5007656861 @default.
- W4386699208 hasAuthorship W4386699208A5009387560 @default.
- W4386699208 hasAuthorship W4386699208A5009790212 @default.
- W4386699208 hasAuthorship W4386699208A5018565112 @default.
- W4386699208 hasAuthorship W4386699208A5030087345 @default.
- W4386699208 hasAuthorship W4386699208A5030217409 @default.
- W4386699208 hasAuthorship W4386699208A5030948491 @default.
- W4386699208 hasAuthorship W4386699208A5036721496 @default.
- W4386699208 hasAuthorship W4386699208A5044523491 @default.
- W4386699208 hasAuthorship W4386699208A5048387675 @default.
- W4386699208 hasAuthorship W4386699208A5064403117 @default.