Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386704637> ?p ?o ?g. }
- W4386704637 abstract "Abstract Angiotensin-converting enzyme inhibitors (ACEIs) reduce arterial stiffness beyond their antihypertensive effect. Studies showed that sulfhydryl ACEIs have the antioxidative potential to improve endothelial function, which might have a clinical effect on arterial distensibility. However, there are no studies that directly compare the effects of sulfhydryl (zofenopril) and non-sulfhydryl ACEIs (enalapril) on arterial stiffness. Therefore, this prospective study aims to compare the effects of enalapril and zofenopril on arterial stiffness and oxidative stress in both short- and long-term treatment of arterial hypertension (AH). Baseline and post-treatment peripheral and central arterial pressure indices, augmentation index (Aix), aortic pulse wave velocity (ao-PWV), serum levels of oxidized low-density cholesterol lipoprotein, LDL and uric acid (UA) were measured. The results showed that acute treatment with zofenopril, in contrast to enalapril, significantly decreased peripheral and central Aix (p < 0.001). Chronic treatment with zofenopril showed a superior effect over enalapril on the reduction of the peripheral systolic arterial pressure with reduction of ao-PWV (p = 0.004), as well as a reduction in peripheral Aix (p = 0.021) and central Aix (p = 0.021). Therefore, this study indicates that zofenopril has beneficial effects on the reduction of arterial stiffness compared to enalapril. It has potent clinical efficacy in AH treatment and further studies should compare its safety and long-term efficacy to other AH drugs that would aid clinicians in treating AH and other various cardiovascular diseases that have arterial stiffness as a common denominator." @default.
- W4386704637 created "2023-09-14" @default.
- W4386704637 creator A5006361667 @default.
- W4386704637 creator A5017170282 @default.
- W4386704637 creator A5038687492 @default.
- W4386704637 creator A5045767892 @default.
- W4386704637 creator A5058016044 @default.
- W4386704637 creator A5072820248 @default.
- W4386704637 creator A5092375476 @default.
- W4386704637 date "2023-09-13" @default.
- W4386704637 modified "2023-10-18" @default.
- W4386704637 title "Effects of Zofenopril on Arterial Stiffness in Hypertension Patients" @default.
- W4386704637 cites W1973440491 @default.
- W4386704637 cites W1985816228 @default.
- W4386704637 cites W1988413497 @default.
- W4386704637 cites W1991056120 @default.
- W4386704637 cites W1991528894 @default.
- W4386704637 cites W1995586381 @default.
- W4386704637 cites W1999869967 @default.
- W4386704637 cites W2000648467 @default.
- W4386704637 cites W2002988219 @default.
- W4386704637 cites W2003398560 @default.
- W4386704637 cites W2005641214 @default.
- W4386704637 cites W2006145534 @default.
- W4386704637 cites W2017666880 @default.
- W4386704637 cites W2020804368 @default.
- W4386704637 cites W2022205513 @default.
- W4386704637 cites W2025603344 @default.
- W4386704637 cites W2033261757 @default.
- W4386704637 cites W2042390289 @default.
- W4386704637 cites W2049445052 @default.
- W4386704637 cites W2050612188 @default.
- W4386704637 cites W2058705761 @default.
- W4386704637 cites W2067140776 @default.
- W4386704637 cites W2069947818 @default.
- W4386704637 cites W2078065869 @default.
- W4386704637 cites W2092810266 @default.
- W4386704637 cites W2093745102 @default.
- W4386704637 cites W2112191043 @default.
- W4386704637 cites W2114741674 @default.
- W4386704637 cites W2130312979 @default.
- W4386704637 cites W2133068045 @default.
- W4386704637 cites W2140615065 @default.
- W4386704637 cites W2141653683 @default.
- W4386704637 cites W2151644209 @default.
- W4386704637 cites W2154952529 @default.
- W4386704637 cites W2162006322 @default.
- W4386704637 cites W2172032309 @default.
- W4386704637 cites W2209658055 @default.
- W4386704637 cites W2415580332 @default.
- W4386704637 cites W2520977577 @default.
- W4386704637 cites W2543869081 @default.
- W4386704637 cites W2592178335 @default.
- W4386704637 cites W2760886327 @default.
- W4386704637 cites W2790436749 @default.
- W4386704637 cites W2794380680 @default.
- W4386704637 cites W2802855866 @default.
- W4386704637 cites W2896151579 @default.
- W4386704637 cites W2898617434 @default.
- W4386704637 cites W2899846335 @default.
- W4386704637 cites W2908125758 @default.
- W4386704637 cites W2977285231 @default.
- W4386704637 cites W2985777810 @default.
- W4386704637 cites W3003374091 @default.
- W4386704637 cites W3035535990 @default.
- W4386704637 cites W3046450525 @default.
- W4386704637 cites W3047715652 @default.
- W4386704637 cites W3125304602 @default.
- W4386704637 cites W3155806174 @default.
- W4386704637 cites W3185144369 @default.
- W4386704637 cites W3196884381 @default.
- W4386704637 cites W3198403876 @default.
- W4386704637 cites W3204694719 @default.
- W4386704637 cites W3206441472 @default.
- W4386704637 cites W3246125 @default.
- W4386704637 cites W4200072628 @default.
- W4386704637 cites W4223927593 @default.
- W4386704637 cites W4243929874 @default.
- W4386704637 cites W4281712788 @default.
- W4386704637 cites W4300417153 @default.
- W4386704637 cites W4306250888 @default.
- W4386704637 cites W4366977526 @default.
- W4386704637 cites W4376131933 @default.
- W4386704637 cites W4386530085 @default.
- W4386704637 cites W72689180 @default.
- W4386704637 doi "https://doi.org/10.1007/s12033-023-00861-5" @default.
- W4386704637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37702881" @default.
- W4386704637 hasPublicationYear "2023" @default.
- W4386704637 type Work @default.
- W4386704637 citedByCount "0" @default.
- W4386704637 crossrefType "journal-article" @default.
- W4386704637 hasAuthorship W4386704637A5006361667 @default.
- W4386704637 hasAuthorship W4386704637A5017170282 @default.
- W4386704637 hasAuthorship W4386704637A5038687492 @default.
- W4386704637 hasAuthorship W4386704637A5045767892 @default.
- W4386704637 hasAuthorship W4386704637A5058016044 @default.
- W4386704637 hasAuthorship W4386704637A5072820248 @default.
- W4386704637 hasAuthorship W4386704637A5092375476 @default.
- W4386704637 hasBestOaLocation W43867046371 @default.
- W4386704637 hasConcept C126322002 @default.