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• W4386707543 abstract "Forensic laboratories need quick and simple technology to improve turnaround times, while delivering reliable results. The goal of this study is first to create a simplified workflow to meet new Academy Standards Board requirements for urine testing in drug-facilitated crime investigations and, second, to create ready-to-go, hands-free testing technology to further streamline analytical procedures. A first of its kind, the ToxBox forensic test kit is used to validate a single analytical procedure for opioids, benzodiazepines, cannabinoids, antidepressants, and several other drug classes. Method performance indicators follow accreditation requirements and include accuracy, precision, measurement uncertainty, calibration models, reportable range, sensitivity, specificity, carryover, interference, ion suppression/enhancement, and analyte stability. Hands-free testing platforms require the use of new suspended-state technology to stabilize NIST-traceable standards premanufactured at precise concentrations in the presence of sample preparation reagents. By suspending all reaction components in the solid state, with air gaps between the phases, reference standards and process controls are built in a ready-to-go format and stabilized for long-term storage in the presence of a sample matrix, β-d-glucuronidase, and enzymatic buffers. Hands-free test kits are removed from storage, incubated at either ambient temperature or 60 °C, and assayed using validated methods. This is the first example of how complex forensic testing workflows can be streamlined with new hands-free testing strategies to meet analytical challenges associated with quantitative and confirmatory analyses." @default.
• W4386707543 created "2023-09-14" @default.
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• W4386707543 date "2023-09-13" @default.
• W4386707543 modified "2023-09-28" @default.
• W4386707543 title "Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations" @default.
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• W4386707543 doi "https://doi.org/10.1021/acs.chemrestox.3c00136" @default.
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• W4386707543 hasPublicationYear "2023" @default.
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