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- W4386708254 abstract "Abstract Purpose Many studies have reported preoperative predictors of overall survival (OS) of patients undergoing liver resection (LR) for Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC); however, the results are inconsistent. We aim to clarify this issue. Methods We enrolled 719 patients with BCLC stage A and single HCC 2.0–5.0 cm (designated A1), 294 patients with BCLC stage A and single HCC > 5.0 cm (designated A2), and 170 patients with BCLC stage B undergoing LR during 2011–2021. Results Multivariate analysis showed that alpha-fetoprotein (AFP) > 400 ng/ml (hazard ratio [HR] = 1.980; 95% confidence interval [CI] = 1.151–3.405; p = 0.014), tumor number > 3 (HR = 2.036; 95% CI = 1.200–3.457; p = 0.008), and Model for End-Stage Liver Disease (MELD) score > 9 (HR = 2.102; 95% CI = 1.244–3.551; p = 0.006) were associated with BCLC stage B patients’ 5-year OS. Using β estimates from multivariate analysis, we constructed a linear predictor of BCLC stage B patients’ OS. Based on the Kaplan–Meier estimator, we divided BCLC stage B patients into two groups: BCLC B1 group with ≤ 3 tumors and MELD score ≤ 9, irrespective of AFP level; and BCLC B2 group with > 3 tumors or MELD score > 9, irrespective of AFP level. The 5-year OS of BCLC A1, A2, B1, and B2 was 78%, 66%, 60%, and 23%, respectively (p < 0.001). OS was significantly different between A1 and A2 (p = 0.012) and B1 and B2 (p < 0.001), but not between A2 and B1 (p = 0.576). Conclusion Patients with BCLC B1 HCC may be ideal candidates for LR because their OS is comparable to that of BCLC A2 patients." @default.
- W4386708254 created "2023-09-14" @default.
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- W4386708254 date "2023-09-13" @default.
- W4386708254 modified "2023-09-26" @default.
- W4386708254 title "Tumor number and Model for End-Stage Liver Disease score as selection criteria for liver resection in intermediate-stage hepatocellular carcinoma" @default.
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- W4386708254 doi "https://doi.org/10.21203/rs.3.rs-3338836/v1" @default.
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