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• W4386708699 abstract "Abstract N-(E)-p-coumaroyl tyrosine (NPCT) is a phenolic amino acid derivative extracted from the Leguminosae Abrus Mollis Hance which has anti-inflammatory activity. In this study, we aimed to investigate the inflammatory activity and mechanism of NPCT by establishing a lipopolysaccharide (LPS)-stimulated RAW264.7 cells in vitro and an injured zebrafish tail fin in vivo. The results showed that NPCT decreased the levels of ROS, NO, IL-6, IL-1β, and IL-18 secreted by LPS-induced RAW 264.7 macrophages. In addition, the results of in vivo studies showed that it inhibited the aggregation of neutrophils and macrophages to the tail after tail cutting stimulation. In summary, NPCT inhibited the production of NO and ROS, decreased the secretions of IL-6, IL-1β, and IL-18, and reduced the aggregation of zebrafish neutrophils and macrophages. Therefore, NPCT may be developed as a potential therapeutic option for inflammatory diseases." @default.
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• W4386708699 date "2023-09-13" @default.
• W4386708699 modified "2023-10-01" @default.
• W4386708699 title "Study on the anti-inflammatory activity of N-( E )-p-Coumaroyl tyrosine in vitro and vivo" @default.
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• W4386708699 doi "https://doi.org/10.21203/rs.3.rs-3260198/v1" @default.
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