FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386708738> ?p ?o ?g. }

• W4386708738 abstract "Abstract Background C hemotherapy resistance is an obstacle to promote the survival of patients with hepatocellular carcinoma (HCC). Therefore, it is essential to find out the promising therapeutic targets to enhance the sensitivity of chemotherapy in HCC. Methods qPCR and western blotting assay were used to examine the expression of signal sequence receptor subunit (SSR2). Colony formation, flow cytometry assay, anchorage independent growth assay and in vivo animal model were used to investigate the effect of SSR2 on resistance of HCC cells to DDP. Western blotting, Luciferase reporter gene technique were used to explore the molecular mechanism of SSR2 on resistance of HCC cells to DDP. Results We found signal sequence receptor subunit (SSR2) is significantly upregulated in HCC, which leads to poor survival. Further analysis showed Downregulation of SSR2 increased sensitivity of HCC cells to DDP. Mechanically, SSR2 inhibited the phosphorylation of YAP and promoted the transcription of Hippo signaling downstream genes. Finally, the inhibitor of Hippo pathway can suppress colony formation and tumorigenesis arousing by upregulation of SSR2. Conclusions Our study provided evidence SSR2 played an important role in HCC progression via Hippo pathway, thus targeting SSR2/Hippo pathway axis might be an effective strategy to overcome DDP resistance in HCC." @default.
• W4386708738 created "2023-09-14" @default.
• W4386708738 creator A5001790457 @default.
• W4386708738 creator A5011303920 @default.
• W4386708738 creator A5017554849 @default.
• W4386708738 creator A5030900478 @default.
• W4386708738 creator A5053968490 @default.
• W4386708738 creator A5068028074 @default.
• W4386708738 creator A5073896543 @default.
• W4386708738 creator A5078459504 @default.
• W4386708738 creator A5083532124 @default.
• W4386708738 creator A5083910650 @default.
• W4386708738 date "2023-09-13" @default.
• W4386708738 modified "2023-09-29" @default.
• W4386708738 title "Downregulation of SSR2 enhanced the sensitivity of hepatocellular carcinoma cells to cisplatin through Hippo pathway" @default.
• W4386708738 cites W1841022483 @default.
• W4386708738 cites W1968910405 @default.
• W4386708738 cites W1969579081 @default.
• W4386708738 cites W1978850079 @default.
• W4386708738 cites W1985268553 @default.
• W4386708738 cites W1997973068 @default.
• W4386708738 cites W2003044806 @default.
• W4386708738 cites W2006778392 @default.
• W4386708738 cites W2023775321 @default.
• W4386708738 cites W2034469841 @default.
• W4386708738 cites W2047524608 @default.
• W4386708738 cites W2049378557 @default.
• W4386708738 cites W2064217847 @default.
• W4386708738 cites W2073157874 @default.
• W4386708738 cites W2074230122 @default.
• W4386708738 cites W2087837402 @default.
• W4386708738 cites W2105193974 @default.
• W4386708738 cites W2123511906 @default.
• W4386708738 cites W2129480424 @default.
• W4386708738 cites W2135495626 @default.
• W4386708738 cites W2148056172 @default.
• W4386708738 cites W2149293660 @default.
• W4386708738 cites W2153038369 @default.
• W4386708738 cites W2154835619 @default.
• W4386708738 cites W2167978765 @default.
• W4386708738 cites W2223413920 @default.
• W4386708738 cites W2358559234 @default.
• W4386708738 cites W2782227398 @default.
• W4386708738 cites W2946065961 @default.
• W4386708738 cites W2950141726 @default.
• W4386708738 cites W3128646645 @default.
• W4386708738 cites W3162657710 @default.
• W4386708738 cites W3204735144 @default.
• W4386708738 cites W4206479175 @default.
• W4386708738 cites W4206592875 @default.
• W4386708738 cites W4211001269 @default.
• W4386708738 doi "https://doi.org/10.21203/rs.3.rs-3247590/v1" @default.
• W4386708738 hasPublicationYear "2023" @default.
• W4386708738 type Work @default.
• W4386708738 citedByCount "0" @default.
• W4386708738 crossrefType "posted-content" @default.
• W4386708738 hasAuthorship W4386708738A5001790457 @default.
• W4386708738 hasAuthorship W4386708738A5011303920 @default.
• W4386708738 hasAuthorship W4386708738A5017554849 @default.
• W4386708738 hasAuthorship W4386708738A5030900478 @default.
• W4386708738 hasAuthorship W4386708738A5053968490 @default.
• W4386708738 hasAuthorship W4386708738A5068028074 @default.
• W4386708738 hasAuthorship W4386708738A5073896543 @default.
• W4386708738 hasAuthorship W4386708738A5078459504 @default.
• W4386708738 hasAuthorship W4386708738A5083532124 @default.
• W4386708738 hasAuthorship W4386708738A5083910650 @default.
• W4386708738 hasBestOaLocation W43867087381 @default.
• W4386708738 hasConcept C104317684 @default.
• W4386708738 hasConcept C127561419 @default.
• W4386708738 hasConcept C172512520 @default.
• W4386708738 hasConcept C185592680 @default.
• W4386708738 hasConcept C2778019345 @default.
• W4386708738 hasConcept C502942594 @default.
• W4386708738 hasConcept C55493867 @default.
• W4386708738 hasConcept C555283112 @default.
• W4386708738 hasConcept C62478195 @default.
• W4386708738 hasConcept C85265743 @default.
• W4386708738 hasConcept C86803240 @default.
• W4386708738 hasConcept C95444343 @default.
• W4386708738 hasConceptScore W4386708738C104317684 @default.
• W4386708738 hasConceptScore W4386708738C127561419 @default.
• W4386708738 hasConceptScore W4386708738C172512520 @default.
• W4386708738 hasConceptScore W4386708738C185592680 @default.
• W4386708738 hasConceptScore W4386708738C2778019345 @default.
• W4386708738 hasConceptScore W4386708738C502942594 @default.
• W4386708738 hasConceptScore W4386708738C55493867 @default.
• W4386708738 hasConceptScore W4386708738C555283112 @default.
• W4386708738 hasConceptScore W4386708738C62478195 @default.
• W4386708738 hasConceptScore W4386708738C85265743 @default.
• W4386708738 hasConceptScore W4386708738C86803240 @default.
• W4386708738 hasConceptScore W4386708738C95444343 @default.
• W4386708738 hasLocation W43867087381 @default.
• W4386708738 hasOpenAccess W4386708738 @default.
• W4386708738 hasPrimaryLocation W43867087381 @default.
• W4386708738 hasRelatedWork W2033672302 @default.
• W4386708738 hasRelatedWork W2068614944 @default.
• W4386708738 hasRelatedWork W2139255374 @default.
• W4386708738 hasRelatedWork W2579945087 @default.
• W4386708738 hasRelatedWork W2740221126 @default.
• W4386708738 hasRelatedWork W2773567891 @default.

• next