Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386710584> ?p ?o ?g. }
- W4386710584 abstract "Growth differentiation factor 15 (GDF15), a member of the transforming growth factor‑β family, is a stress‑induced cytokine. Under normal circumstances, the expression of GDF15 is low in most tissues. It is highly expressed during tissue injury, inflammation, oxidative stress and cancer. GDF15 has been established as a biomarker in patients with cancer, and is associated with cancer cachexia (CC) and poor survival. CC is a multifactorial metabolic disorder characterized by severe muscle and adipose tissue atrophy, loss of appetite, anemia and bone loss. Cachexia leads to reductions in quality of life and tolerance to anticancer therapy, and results in a poor prognosis in cancer patients. Dysregulated GDF15 levels have been discovered in patients with CC and animal models, where they have been found to be involved in anorexia and weight loss. Although studies have suggested that GDF15 mediates anorexia and weight loss in CC through its neuroreceptor, glial cell‑lineage neurotrophic factor family receptor α‑like, the effects of GDF15 on CC and the potential regulatory mechanisms require further elucidation. In the present review, the characteristics of GDF15 and its roles and molecular mechanisms in CC are elaborated. The targeting of GDF15 as a potential therapeutic strategy for CC is also discussed." @default.
- W4386710584 created "2023-09-14" @default.
- W4386710584 creator A5017947172 @default.
- W4386710584 creator A5054671669 @default.
- W4386710584 creator A5065874863 @default.
- W4386710584 creator A5088351031 @default.
- W4386710584 date "2023-09-13" @default.
- W4386710584 modified "2023-10-17" @default.
- W4386710584 title "Role of growth differentiation factor 15 in cancer cachexia (Review)" @default.
- W4386710584 cites W1212923657 @default.
- W4386710584 cites W1556530806 @default.
- W4386710584 cites W1831636259 @default.
- W4386710584 cites W1965860042 @default.
- W4386710584 cites W1970789341 @default.
- W4386710584 cites W1975913194 @default.
- W4386710584 cites W2003064100 @default.
- W4386710584 cites W2038181834 @default.
- W4386710584 cites W2043950453 @default.
- W4386710584 cites W2065024492 @default.
- W4386710584 cites W2089917150 @default.
- W4386710584 cites W2107423980 @default.
- W4386710584 cites W2115452947 @default.
- W4386710584 cites W2116239490 @default.
- W4386710584 cites W2135214326 @default.
- W4386710584 cites W2145280166 @default.
- W4386710584 cites W2171338952 @default.
- W4386710584 cites W2279428213 @default.
- W4386710584 cites W2417891838 @default.
- W4386710584 cites W2509713729 @default.
- W4386710584 cites W2533287785 @default.
- W4386710584 cites W2557895031 @default.
- W4386710584 cites W2573888447 @default.
- W4386710584 cites W2600798053 @default.
- W4386710584 cites W2634808929 @default.
- W4386710584 cites W2784374589 @default.
- W4386710584 cites W2787407338 @default.
- W4386710584 cites W2789619620 @default.
- W4386710584 cites W2796245755 @default.
- W4386710584 cites W2799956534 @default.
- W4386710584 cites W2802706983 @default.
- W4386710584 cites W2888677943 @default.
- W4386710584 cites W2901644252 @default.
- W4386710584 cites W2905205873 @default.
- W4386710584 cites W2934452916 @default.
- W4386710584 cites W2981959829 @default.
- W4386710584 cites W2989907427 @default.
- W4386710584 cites W3006104116 @default.
- W4386710584 cites W3008261843 @default.
- W4386710584 cites W3012938759 @default.
- W4386710584 cites W3017278094 @default.
- W4386710584 cites W3026163675 @default.
- W4386710584 cites W3033761014 @default.
- W4386710584 cites W3041625692 @default.
- W4386710584 cites W3086286991 @default.
- W4386710584 cites W3087678447 @default.
- W4386710584 cites W3093916192 @default.
- W4386710584 cites W3103243932 @default.
- W4386710584 cites W3112509373 @default.
- W4386710584 cites W3114456458 @default.
- W4386710584 cites W3116267790 @default.
- W4386710584 cites W3119664087 @default.
- W4386710584 cites W3121839668 @default.
- W4386710584 cites W3131180186 @default.
- W4386710584 cites W3133510909 @default.
- W4386710584 cites W3137920377 @default.
- W4386710584 cites W3160822438 @default.
- W4386710584 cites W3175122357 @default.
- W4386710584 cites W3176950745 @default.
- W4386710584 cites W3194162311 @default.
- W4386710584 cites W3196272803 @default.
- W4386710584 cites W3199777466 @default.
- W4386710584 cites W3202533849 @default.
- W4386710584 cites W3204286065 @default.
- W4386710584 cites W3208682343 @default.
- W4386710584 cites W3211999698 @default.
- W4386710584 cites W3214088285 @default.
- W4386710584 cites W4200253304 @default.
- W4386710584 cites W4205560642 @default.
- W4386710584 cites W4220926207 @default.
- W4386710584 cites W4224222238 @default.
- W4386710584 cites W4224228716 @default.
- W4386710584 cites W4224294532 @default.
- W4386710584 cites W4226484889 @default.
- W4386710584 cites W4229025949 @default.
- W4386710584 cites W4280531966 @default.
- W4386710584 cites W4281484116 @default.
- W4386710584 cites W4281689838 @default.
- W4386710584 cites W4282970371 @default.
- W4386710584 cites W4283744646 @default.
- W4386710584 cites W4285014313 @default.
- W4386710584 cites W4285091134 @default.
- W4386710584 cites W4293659713 @default.
- W4386710584 cites W4306385374 @default.
- W4386710584 cites W4313240823 @default.
- W4386710584 cites W4315433103 @default.
- W4386710584 cites W4319159272 @default.
- W4386710584 cites W4361277983 @default.
- W4386710584 cites W4361278786 @default.
- W4386710584 cites W4366822164 @default.
- W4386710584 cites W4376226599 @default.