FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386712162> ?p ?o ?g. }

• W4386712162 abstract "Abstract To solve the traditional radiotherapy obstacles, and also to enhance the radiation therapy efficacy various radiosensitizers have been developed. Radiosensitizers are promising agents that under X-ray irradiation enhance injury to tumor tissue by accelerating DNA damage. In this report, silver-silver sulfide nanoparticles (Ag-Ag 2 S NPs) were synthesized via a facile, one-pot and environmentally friendly biomineralization method. Ag-Ag 2 S was coated with bovine serum albumin (BSA) in situ and applied as an X-ray sensitizer to enhance the efficiency of radiotherapy. Also, folic acid (FA) was conjugated to Ag-Ag 2 S@BSA to impart active targeting capability to the final formulation (Ag-Ag 2 S@BSA-FA). Prepared NPs were characterized by transmission electron microscopes (TEM), scanning electron microscope (SEM), dynamic light scattering (DLS), ultraviolet–visible spectroscopy (UV–Vis), X-ray diffraction analysis (XRD), and X-ray photoelectron spectroscopy (XPS) techniques. Results show that most of the NPs have well-defined uniform Janus structures. The biocompatibility of the NPs was then evaluated both in vitro and in vivo. A series of in vitro assays were performed on 4T1 cancer cells to evaluate the therapeutic efficacy of the designed NPs. In addition, the radio-enhancing ability of the NPs was tested on the 4T1 breast cancer murine model. MTT, live and dead cell staining, apoptosis, ROS generation, and clonogenic in vitro assays demonstrated the efficacy of NPs as radiosensitizers in radiotherapy. In vivo results as well as H&E staining tumor tissues confirmed tumor destruction in the group that received Ag-Ag 2 S@BSA-FA NPs and exposed to X-ray. The results showed that prepared tumor-targeted Ag-Ag 2 S@BSA-FA NPs could be potential candidates as radiosensitizers for enhanced radiotherapy." @default.
• W4386712162 created "2023-09-14" @default.
• W4386712162 creator A5005756615 @default.
• W4386712162 creator A5010975397 @default.
• W4386712162 creator A5013746981 @default.
• W4386712162 creator A5043571888 @default.
• W4386712162 creator A5045822860 @default.
• W4386712162 creator A5051948797 @default.
• W4386712162 creator A5053495030 @default.
• W4386712162 creator A5055765367 @default.
• W4386712162 creator A5066843568 @default.
• W4386712162 creator A5087812545 @default.
• W4386712162 creator A5089111354 @default.
• W4386712162 creator A5092863611 @default.
• W4386712162 date "2023-09-13" @default.
• W4386712162 modified "2023-09-27" @default.
• W4386712162 title "Facile preparation of silver based radiosensitizers via biomineralization method for enhanced in vivo breast cancer radiotherapy" @default.
• W4386712162 cites W1512034926 @default.
• W4386712162 cites W1720002012 @default.
• W4386712162 cites W1742315769 @default.
• W4386712162 cites W1967520630 @default.
• W4386712162 cites W1990895399 @default.
• W4386712162 cites W1992465418 @default.
• W4386712162 cites W2013886018 @default.
• W4386712162 cites W2018822486 @default.
• W4386712162 cites W2025571345 @default.
• W4386712162 cites W2043621883 @default.
• W4386712162 cites W2085617626 @default.
• W4386712162 cites W2132834292 @default.
• W4386712162 cites W2154745425 @default.
• W4386712162 cites W2158637663 @default.
• W4386712162 cites W2162594126 @default.
• W4386712162 cites W2209394102 @default.
• W4386712162 cites W2290439009 @default.
• W4386712162 cites W2313142763 @default.
• W4386712162 cites W2316127698 @default.
• W4386712162 cites W2321470509 @default.
• W4386712162 cites W2324481606 @default.
• W4386712162 cites W2403481844 @default.
• W4386712162 cites W2407297656 @default.
• W4386712162 cites W2510789695 @default.
• W4386712162 cites W2733085110 @default.
• W4386712162 cites W2751852570 @default.
• W4386712162 cites W2759465998 @default.
• W4386712162 cites W2802492120 @default.
• W4386712162 cites W2889357461 @default.
• W4386712162 cites W2937682709 @default.
• W4386712162 cites W2963620993 @default.
• W4386712162 cites W2990561242 @default.
• W4386712162 cites W2995589939 @default.
• W4386712162 cites W2997101177 @default.
• W4386712162 cites W2999544518 @default.
• W4386712162 cites W3016337090 @default.
• W4386712162 cites W3092070898 @default.
• W4386712162 cites W3112472804 @default.
• W4386712162 cites W3128646645 @default.
• W4386712162 cites W3147142721 @default.
• W4386712162 cites W3162713906 @default.
• W4386712162 cites W3164749978 @default.
• W4386712162 cites W3166593186 @default.
• W4386712162 cites W3169406559 @default.
• W4386712162 cites W3183831424 @default.
• W4386712162 cites W3199559884 @default.
• W4386712162 cites W3211897019 @default.
• W4386712162 cites W4200382633 @default.
• W4386712162 cites W4200584507 @default.
• W4386712162 cites W4241049853 @default.
• W4386712162 cites W4292641097 @default.
• W4386712162 cites W4322617771 @default.
• W4386712162 doi "https://doi.org/10.1038/s41598-023-40763-9" @default.
• W4386712162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37704633" @default.
• W4386712162 hasPublicationYear "2023" @default.
• W4386712162 type Work @default.
• W4386712162 citedByCount "0" @default.
• W4386712162 crossrefType "journal-article" @default.
• W4386712162 hasAuthorship W4386712162A5005756615 @default.
• W4386712162 hasAuthorship W4386712162A5010975397 @default.
• W4386712162 hasAuthorship W4386712162A5013746981 @default.
• W4386712162 hasAuthorship W4386712162A5043571888 @default.
• W4386712162 hasAuthorship W4386712162A5045822860 @default.
• W4386712162 hasAuthorship W4386712162A5051948797 @default.
• W4386712162 hasAuthorship W4386712162A5053495030 @default.
• W4386712162 hasAuthorship W4386712162A5055765367 @default.
• W4386712162 hasAuthorship W4386712162A5066843568 @default.
• W4386712162 hasAuthorship W4386712162A5087812545 @default.
• W4386712162 hasAuthorship W4386712162A5089111354 @default.
• W4386712162 hasAuthorship W4386712162A5092863611 @default.
• W4386712162 hasBestOaLocation W43867121621 @default.
• W4386712162 hasConcept C13965031 @default.
• W4386712162 hasConcept C150903083 @default.
• W4386712162 hasConcept C171250308 @default.
• W4386712162 hasConcept C178790620 @default.
• W4386712162 hasConcept C185592680 @default.
• W4386712162 hasConcept C192562407 @default.
• W4386712162 hasConcept C202751555 @default.
• W4386712162 hasConcept C207001950 @default.
• W4386712162 hasConcept C2777230088 @default.
• W4386712162 hasConcept C2780783641 @default.
• W4386712162 hasConcept C55493867 @default.
• W4386712162 hasConcept C86803240 @default.

• next