Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386714831> ?p ?o ?g. }
- W4386714831 abstract "Abstract Glioblastoma undergoes a complex and dynamic evolution involving genetic and epigenetic changes. Understanding the mechanisms underlying this evolution is vital for the development of efficient therapeutic strategies. Although treatment resistance is associated with intratumoral heterogeneity in glioblastoma, it remains uncertain whether hypometabolic and hypermetabolic lesions observed through positron emission tomography (PET) imaging are influenced by spatial intratumoral genomic evolution. In this study, we precisely isolated autologous hypometabolic and hypermetabolic lesions from glioblastoma using advanced neurosurgical and brain tumor imaging technologies, followed by comprehensive whole-genome exome and transcriptome analyses. Our findings revealed that hypermetabolic lesions evolved from hypometabolic lesions, harbored shrewd focal amplifications and deletions, and exhibited a higher frequency of critical genomic alterations linked to increased aggressiveness, upregulated APOBEC3 and hypoxic genes, and downregulated putative tumor suppressors. This study highlights spatial genomic evolution with diagnostic implications and unveils the obstacles and possibilities that should be considered in the development of novel therapeutic strategies. Statement of significance: Glioblastoma is a multifaceted disease that is difficult to treat, and insights into the metabolic gradient observed in imaging and the underlying role of genomic evolution are lacking. This study is the first to investigate the molecular basis of hypermetabolic tumor lesions in glioblastoma using precise three-dimensional biopsy isolation, whole genome/exome, and mRNA sequencing. These findings have diagnostic significance, provide insights into therapeutic resistance, and shed light on the obstacles encountered by precision therapeutics for glioblastoma." @default.
- W4386714831 created "2023-09-14" @default.
- W4386714831 creator A5011549891 @default.
- W4386714831 creator A5021109428 @default.
- W4386714831 creator A5023573690 @default.
- W4386714831 creator A5034544601 @default.
- W4386714831 creator A5050417583 @default.
- W4386714831 creator A5051020687 @default.
- W4386714831 creator A5075169782 @default.
- W4386714831 creator A5076125351 @default.
- W4386714831 creator A5077825277 @default.
- W4386714831 creator A5084337679 @default.
- W4386714831 creator A5089115666 @default.
- W4386714831 date "2023-09-12" @default.
- W4386714831 modified "2023-09-29" @default.
- W4386714831 title "Insight into spatial intratumoral genomic evolution in glioblastoma" @default.
- W4386714831 cites W1493048246 @default.
- W4386714831 cites W1540050006 @default.
- W4386714831 cites W1842792112 @default.
- W4386714831 cites W2001077214 @default.
- W4386714831 cites W2011957420 @default.
- W4386714831 cites W2090757807 @default.
- W4386714831 cites W2096287682 @default.
- W4386714831 cites W2096746187 @default.
- W4386714831 cites W2109991075 @default.
- W4386714831 cites W2114843025 @default.
- W4386714831 cites W2149441684 @default.
- W4386714831 cites W2151980465 @default.
- W4386714831 cites W2155943701 @default.
- W4386714831 cites W2161289668 @default.
- W4386714831 cites W2161815151 @default.
- W4386714831 cites W2163676912 @default.
- W4386714831 cites W2163874870 @default.
- W4386714831 cites W2167185669 @default.
- W4386714831 cites W2171892226 @default.
- W4386714831 cites W2197269124 @default.
- W4386714831 cites W2521492299 @default.
- W4386714831 cites W2533448509 @default.
- W4386714831 cites W2554863679 @default.
- W4386714831 cites W2582574843 @default.
- W4386714831 cites W2593219267 @default.
- W4386714831 cites W2607129810 @default.
- W4386714831 cites W2607166912 @default.
- W4386714831 cites W2751852104 @default.
- W4386714831 cites W2755681539 @default.
- W4386714831 cites W2757232748 @default.
- W4386714831 cites W2760634972 @default.
- W4386714831 cites W2775286316 @default.
- W4386714831 cites W2790583237 @default.
- W4386714831 cites W2894102714 @default.
- W4386714831 cites W2910111050 @default.
- W4386714831 cites W2922948425 @default.
- W4386714831 cites W2944545583 @default.
- W4386714831 cites W2961217357 @default.
- W4386714831 cites W2964237627 @default.
- W4386714831 cites W2993990549 @default.
- W4386714831 cites W2999304067 @default.
- W4386714831 cites W3001572379 @default.
- W4386714831 cites W3004204853 @default.
- W4386714831 cites W3004442100 @default.
- W4386714831 cites W3005469082 @default.
- W4386714831 cites W3016364844 @default.
- W4386714831 cites W3027364034 @default.
- W4386714831 cites W3047143891 @default.
- W4386714831 cites W3096112873 @default.
- W4386714831 cites W3107322429 @default.
- W4386714831 cites W3127739024 @default.
- W4386714831 cites W3155327894 @default.
- W4386714831 cites W3173975756 @default.
- W4386714831 cites W3174246647 @default.
- W4386714831 cites W3192333554 @default.
- W4386714831 cites W3204437300 @default.
- W4386714831 cites W3213568827 @default.
- W4386714831 cites W4200499803 @default.
- W4386714831 cites W4211033096 @default.
- W4386714831 cites W4225529913 @default.
- W4386714831 cites W4292856186 @default.
- W4386714831 cites W4293703371 @default.
- W4386714831 cites W4296344980 @default.
- W4386714831 cites W4301595791 @default.
- W4386714831 cites W4308834893 @default.
- W4386714831 cites W4313564045 @default.
- W4386714831 doi "https://doi.org/10.1101/2023.09.11.557112" @default.
- W4386714831 hasPublicationYear "2023" @default.
- W4386714831 type Work @default.
- W4386714831 citedByCount "0" @default.
- W4386714831 crossrefType "posted-content" @default.
- W4386714831 hasAuthorship W4386714831A5011549891 @default.
- W4386714831 hasAuthorship W4386714831A5021109428 @default.
- W4386714831 hasAuthorship W4386714831A5023573690 @default.
- W4386714831 hasAuthorship W4386714831A5034544601 @default.
- W4386714831 hasAuthorship W4386714831A5050417583 @default.
- W4386714831 hasAuthorship W4386714831A5051020687 @default.
- W4386714831 hasAuthorship W4386714831A5075169782 @default.
- W4386714831 hasAuthorship W4386714831A5076125351 @default.
- W4386714831 hasAuthorship W4386714831A5077825277 @default.
- W4386714831 hasAuthorship W4386714831A5084337679 @default.
- W4386714831 hasAuthorship W4386714831A5089115666 @default.
- W4386714831 hasBestOaLocation W43867148311 @default.
- W4386714831 hasConcept C104317684 @default.