FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386715005> ?p ?o ?g. }

• W4386715005 endingPage "1383" @default.
• W4386715005 startingPage "1383" @default.
• W4386715005 abstract "Indomethacin is a non-selective NSAID used against pain and inflammation. Although cyclooxygenase (COX) inhibition is considered indomethacin's primary action mechanism, COX-independent ways are associated with beneficial effects in cancer. In colon cancer cells, the activation of the peroxisome proliferator-activated receptor-γ (PPAR-γ) is related to the increase in spermidine/spermine-N1-acetyltransferase-1 (SSAT-1), a key enzyme for polyamine degradation, and related to cell cycle arrest. Indomethacin increases the SSAT-1 levels in lung cancer cells; however, the mechanism relying on the SSAT-1 increase is unclear. Thus, we asked for the influence of the PPAR-γ on the SSAT-1 expression in two lung cancer cell lines: H1299 and A549. We found that the inhibition of PPAR-γ with GW9662 did not revert the increase in SSAT-1 induced by indomethacin. Because the mRNA of SSAT-1 suffers a pre-translation retention step by nucleolin, a nucleolar protein, we explored the relationship between indomethacin and the upstream translation regulators of SSAT-1. We found that indomethacin decreases the nucleolin levels and the cyclin-dependent kinase 1 (CDK1) levels, which phosphorylates nucleolin in mitosis. Overexpression of nucleolin partially reverts the effect of indomethacin over cell viability and SSAT-1 levels. On the other hand, Casein Kinase, known for phosphorylating nucleolin during interphase, is not modified by indomethacin. SSAT-1 exerts its antiproliferative effect by acetylating polyamines, a process reverted by the polyamine oxidase (PAOX). Recently, methoctramine was described as the most specific inhibitor of PAOX. Thus, we asked if methoctramine could increase the effect of indomethacin. We found that, when combined, indomethacin and methoctramine have a synergistic effect against NSCLC cells in vitro. These results suggest that indomethacin increases the SSAT-1 levels by reducing the CDK1-nucleolin regulatory axis, and the PAOX inhibition with methoctramine could improve the antiproliferative effect of indomethacin." @default.
• W4386715005 created "2023-09-14" @default.
• W4386715005 creator A5001928855 @default.
• W4386715005 creator A5002594078 @default.
• W4386715005 creator A5019428194 @default.
• W4386715005 creator A5023279757 @default.
• W4386715005 creator A5025710517 @default.
• W4386715005 creator A5035189926 @default.
• W4386715005 creator A5037404962 @default.
• W4386715005 creator A5061860784 @default.
• W4386715005 creator A5092864321 @default.
• W4386715005 creator A5092864322 @default.
• W4386715005 date "2023-09-12" @default.
• W4386715005 modified "2023-10-17" @default.
• W4386715005 title "Indomethacin Induces Spermidine/Spermine-N1-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells" @default.
• W4386715005 cites W1492668272 @default.
• W4386715005 cites W1501970115 @default.
• W4386715005 cites W1568755077 @default.
• W4386715005 cites W1575032037 @default.
• W4386715005 cites W1578932543 @default.
• W4386715005 cites W1665409553 @default.
• W4386715005 cites W1876720422 @default.
• W4386715005 cites W1976523417 @default.
• W4386715005 cites W1982814560 @default.
• W4386715005 cites W1989811320 @default.
• W4386715005 cites W1994663540 @default.
• W4386715005 cites W1998232267 @default.
• W4386715005 cites W1998855859 @default.
• W4386715005 cites W2006125716 @default.
• W4386715005 cites W2009356080 @default.
• W4386715005 cites W2013165612 @default.
• W4386715005 cites W2033387723 @default.
• W4386715005 cites W2038580538 @default.
• W4386715005 cites W2046730497 @default.
• W4386715005 cites W2053969922 @default.
• W4386715005 cites W2055587059 @default.
• W4386715005 cites W2073600895 @default.
• W4386715005 cites W2081556765 @default.
• W4386715005 cites W2089101049 @default.
• W4386715005 cites W2094809302 @default.
• W4386715005 cites W2131840121 @default.
• W4386715005 cites W2136718036 @default.
• W4386715005 cites W2138217484 @default.
• W4386715005 cites W2154545410 @default.
• W4386715005 cites W2162505912 @default.
• W4386715005 cites W2167580059 @default.
• W4386715005 cites W2168972147 @default.
• W4386715005 cites W2232835389 @default.
• W4386715005 cites W2344726805 @default.
• W4386715005 cites W2613134542 @default.
• W4386715005 cites W2730837450 @default.
• W4386715005 cites W2732566269 @default.
• W4386715005 cites W2748237403 @default.
• W4386715005 cites W2766866658 @default.
• W4386715005 cites W2768870915 @default.
• W4386715005 cites W2809933832 @default.
• W4386715005 cites W2891238555 @default.
• W4386715005 cites W2895875588 @default.
• W4386715005 cites W2896098524 @default.
• W4386715005 cites W2918634610 @default.
• W4386715005 cites W2921493231 @default.
• W4386715005 cites W2966819516 @default.
• W4386715005 cites W2999585526 @default.
• W4386715005 cites W3007095233 @default.
• W4386715005 cites W3044949124 @default.
• W4386715005 cites W3083841916 @default.
• W4386715005 cites W3100201155 @default.
• W4386715005 cites W3168911191 @default.
• W4386715005 cites W3175042842 @default.
• W4386715005 cites W3205873808 @default.
• W4386715005 cites W4213371154 @default.
• W4386715005 doi "https://doi.org/10.3390/biom13091383" @default.
• W4386715005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37759783" @default.
• W4386715005 hasPublicationYear "2023" @default.
• W4386715005 type Work @default.
• W4386715005 citedByCount "0" @default.
• W4386715005 crossrefType "journal-article" @default.
• W4386715005 hasAuthorship W4386715005A5001928855 @default.
• W4386715005 hasAuthorship W4386715005A5002594078 @default.
• W4386715005 hasAuthorship W4386715005A5019428194 @default.
• W4386715005 hasAuthorship W4386715005A5023279757 @default.
• W4386715005 hasAuthorship W4386715005A5025710517 @default.
• W4386715005 hasAuthorship W4386715005A5035189926 @default.
• W4386715005 hasAuthorship W4386715005A5037404962 @default.
• W4386715005 hasAuthorship W4386715005A5061860784 @default.
• W4386715005 hasAuthorship W4386715005A5092864321 @default.
• W4386715005 hasAuthorship W4386715005A5092864322 @default.
• W4386715005 hasBestOaLocation W43867150051 @default.
• W4386715005 hasConcept C121608353 @default.
• W4386715005 hasConcept C181199279 @default.
• W4386715005 hasConcept C183873130 @default.
• W4386715005 hasConcept C185592680 @default.
• W4386715005 hasConcept C190062978 @default.
• W4386715005 hasConcept C2776109719 @default.
• W4386715005 hasConcept C2776525860 @default.
• W4386715005 hasConcept C2777167505 @default.
• W4386715005 hasConcept C2777497464 @default.
• W4386715005 hasConcept C2780115381 @default.

• next