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- W4386715599 startingPage "921" @default.
- W4386715599 abstract "Sporotrichosis caused by Sporothrix brasiliensis is an emergent mycosis that is now a worldwide concern. One important step to sporotrichosis control is its correct treatment. However, limitations abound; thus, new antifungals, mainly focused on S. brasiliensis, are urgently needed. We performed a systematic review (following the PRISMA guideline) focused on (1) the global distribution of human and animal sporotrichosis by S. brasiliensis, especially outside of Brazil; (2) appraising therapies tested against this pathogen. We identified sporotrichosis caused by S. brasiliensis reported in five countries (Paraguay, Chile, Argentina, the United Kingdom, and the United States) in addition to Brazil, occurring on three continents, highlighting the epidemiological scenario in Argentina with an important increase in reported cases in recent years. Regarding the antifungal activity of drugs, 25 articles described the in vitro action of 20 unique chemicals and eight repurposed drugs against S. brasiliensis. Only five studies reported in vivo activity against S. brasiliensis (five drugs) using invertebrate and vertebrate models. Sporotrichosis caused by S. brasiliensis has a global impact and it is no longer specifically a Brazilian problem. We review the need for understanding the disease epidemiology, education of clinicians and of the populace, organization of health care delivery to respond to a spreading epidemic, and research on therapy for sporotrichosis." @default.
- W4386715599 created "2023-09-14" @default.
- W4386715599 creator A5005676299 @default.
- W4386715599 creator A5021143803 @default.
- W4386715599 creator A5065249087 @default.
- W4386715599 creator A5085519842 @default.
- W4386715599 date "2023-09-13" @default.
- W4386715599 modified "2023-10-17" @default.
- W4386715599 title "Sporothrix brasiliensis: Epidemiology, Therapy, and Recent Developments" @default.
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