FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386723671> ?p ?o ?g. }

• W4386723671 abstract "Bitter taste receptors are involved not only in taste perception but in various physiological functions as their anatomical location is not restricted to the gustatory system. We previously demonstrated expression and activity of the subtype hTAS2R46 in human airway smooth muscle and broncho-epithelial cells, and here we show its expression and functionality in human skeletal muscle cells. Three different cellular models were used: micro-dissected human skeletal tissues, human myoblasts/myotubes and human skeletal muscle cells differentiated from urine stem cells of healthy donors. We used qPCR, immunohistochemistry and immunofluorescence analysis to evaluate gene and protein hTAS2R46 expression. In order to explore receptor activity, cells were incubated with the specific bitter ligands absinthin and 3ß-hydroxydihydrocostunolide, and calcium oscillation and relaxation were evaluated by calcium imaging and collagen assay, respectively, after a cholinergic stimulus. We show, for the first time, experimentally the presence and functionality of a type 2 bitter receptor in human skeletal muscle cells. Given the tendentially protective role of the bitter receptors starting from the oral cavity and following also in the other ectopic sites, and given its expression already at the myoblast level, we hypothesize that the bitter receptor can play an important role in the development, maintenance and in the protection of muscle tissue functions." @default.
• W4386723671 created "2023-09-14" @default.
• W4386723671 creator A5003703342 @default.
• W4386723671 creator A5005259676 @default.
• W4386723671 creator A5007615779 @default.
• W4386723671 creator A5020039755 @default.
• W4386723671 creator A5022803125 @default.
• W4386723671 creator A5072084623 @default.
• W4386723671 creator A5074726874 @default.
• W4386723671 creator A5078017924 @default.
• W4386723671 creator A5082372618 @default.
• W4386723671 creator A5087588523 @default.
• W4386723671 creator A5090830510 @default.
• W4386723671 creator A5091449550 @default.
• W4386723671 creator A5092866025 @default.
• W4386723671 creator A5092866026 @default.
• W4386723671 date "2023-09-12" @default.
• W4386723671 modified "2023-10-15" @default.
• W4386723671 title "Bitter taste receptor (TAS2R) 46 in human skeletal muscle: expression and activity" @default.
• W4386723671 cites W1967177519 @default.
• W4386723671 cites W1969709153 @default.
• W4386723671 cites W2020179522 @default.
• W4386723671 cites W2052099974 @default.
• W4386723671 cites W2064180222 @default.
• W4386723671 cites W2074732360 @default.
• W4386723671 cites W2081364727 @default.
• W4386723671 cites W2114783676 @default.
• W4386723671 cites W2121145363 @default.
• W4386723671 cites W2121864128 @default.
• W4386723671 cites W2122283286 @default.
• W4386723671 cites W2133302347 @default.
• W4386723671 cites W2169702025 @default.
• W4386723671 cites W2169795817 @default.
• W4386723671 cites W2192271535 @default.
• W4386723671 cites W2235395345 @default.
• W4386723671 cites W2312648644 @default.
• W4386723671 cites W2326939552 @default.
• W4386723671 cites W2338813507 @default.
• W4386723671 cites W2530612023 @default.
• W4386723671 cites W2549770418 @default.
• W4386723671 cites W2565101023 @default.
• W4386723671 cites W2577171598 @default.
• W4386723671 cites W2579869862 @default.
• W4386723671 cites W2585049727 @default.
• W4386723671 cites W2597195398 @default.
• W4386723671 cites W2619457745 @default.
• W4386723671 cites W2734977949 @default.
• W4386723671 cites W2954281693 @default.
• W4386723671 cites W2970228891 @default.
• W4386723671 cites W2982165643 @default.
• W4386723671 cites W3006489173 @default.
• W4386723671 cites W3023591122 @default.
• W4386723671 cites W3033218024 @default.
• W4386723671 cites W3039172220 @default.
• W4386723671 cites W3044384155 @default.
• W4386723671 cites W3129254318 @default.
• W4386723671 cites W3132917702 @default.
• W4386723671 cites W3205114982 @default.
• W4386723671 cites W3207490374 @default.
• W4386723671 cites W4210457735 @default.
• W4386723671 cites W4281769716 @default.
• W4386723671 cites W4309608349 @default.
• W4386723671 cites W4384469706 @default.
• W4386723671 doi "https://doi.org/10.3389/fphar.2023.1205651" @default.
• W4386723671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37771728" @default.
• W4386723671 hasPublicationYear "2023" @default.
• W4386723671 type Work @default.
• W4386723671 citedByCount "0" @default.
• W4386723671 crossrefType "journal-article" @default.
• W4386723671 hasAuthorship W4386723671A5003703342 @default.
• W4386723671 hasAuthorship W4386723671A5005259676 @default.
• W4386723671 hasAuthorship W4386723671A5007615779 @default.
• W4386723671 hasAuthorship W4386723671A5020039755 @default.
• W4386723671 hasAuthorship W4386723671A5022803125 @default.
• W4386723671 hasAuthorship W4386723671A5072084623 @default.
• W4386723671 hasAuthorship W4386723671A5074726874 @default.
• W4386723671 hasAuthorship W4386723671A5078017924 @default.
• W4386723671 hasAuthorship W4386723671A5082372618 @default.
• W4386723671 hasAuthorship W4386723671A5087588523 @default.
• W4386723671 hasAuthorship W4386723671A5090830510 @default.
• W4386723671 hasAuthorship W4386723671A5091449550 @default.
• W4386723671 hasAuthorship W4386723671A5092866025 @default.
• W4386723671 hasAuthorship W4386723671A5092866026 @default.
• W4386723671 hasBestOaLocation W43867236711 @default.
• W4386723671 hasConcept C126322002 @default.
• W4386723671 hasConcept C134018914 @default.
• W4386723671 hasConcept C170493617 @default.
• W4386723671 hasConcept C207200792 @default.
• W4386723671 hasConcept C2776032975 @default.
• W4386723671 hasConcept C2779959927 @default.
• W4386723671 hasConcept C3763915 @default.
• W4386723671 hasConcept C519063684 @default.
• W4386723671 hasConcept C55493867 @default.
• W4386723671 hasConcept C71924100 @default.
• W4386723671 hasConcept C86803240 @default.
• W4386723671 hasConcept C95444343 @default.
• W4386723671 hasConceptScore W4386723671C126322002 @default.
• W4386723671 hasConceptScore W4386723671C134018914 @default.
• W4386723671 hasConceptScore W4386723671C170493617 @default.
• W4386723671 hasConceptScore W4386723671C207200792 @default.

• next