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• W4386723941 abstract "Abstract Objective The aim of this study was to explore the associations between different body mass index (BMI) levels and the risk of different lung function impairment (LFI) in Chinese people aged over 40 years. Methods We used a multi-stage stratified cluster random sampling method to investigate 3000 residents aged over 40 years from 5 areas in Hubei province of China in 2019-20. The data on questionnaire, physical measurements, and spirometry of the participants were collected. The associations of different BMI levels with the risk of different LFI were analyzed using multivariate logistic regressions after complex weighting. Results A total of 2860 subjects were included. The prevalence (95% CI ) of obstructive lung disease (OLD), restrictive lung disease (RLD), mixed lung disease (MLD), chronic obstructive pulmonary disease (COPD), COPD mild, and COPD moderate/severe/very severe were 24.1% (95% CI: 22.2–26.2), 11.6% (95% CI: 10.3–12.9), 4.0% (95% CI: 3.3–4.8), 12.6% (95% CI: 11.0-14.1), 7.2% (95% CI: 6.0-8.4), and 5.3% (95% CI: 4.3–6.4) respectively. After multivariate adjustment, the risk of OLD, COPD, and COPD mild decreased with the increment of BMI levels (both P for trend < 0.05). When compared to the normal weight group, the overweight group and obese group were at lower risk of experiencing OLD than normal group, the ORs were 0.77 (95% CI: 0.59–0.99) and 0.59 (95% CI: 0.40–0.86) respectively. The obese group was at lower risk for people with COPD mild (OR: 0.42, 95%CI: 0.21–0.85). Participants in underweight group were more likely to experience COPD and COPD moderate/severe/very severe, the ORs were 2.82 (95% CI: 1.07–7.39) and 3.89 (95% CI: 1.28–11.87) respectively. Conclusion Higher BMI levels were associated with an decreased risk of OLD and COPD. Obesity had a protective effect on lung function in OLD patients and COPD patients. However, there was no significant difference in RLD and MLD prevalence between different BMI groups." @default.
• W4386723941 created "2023-09-14" @default.
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• W4386723941 date "2023-09-13" @default.
• W4386723941 modified "2023-09-26" @default.
• W4386723941 title "Associations between different body mass index and risk of lung function impairment in Chinese people aged over 40 years: a multicenter cross-sectional study" @default.
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• W4386723941 doi "https://doi.org/10.21203/rs.3.rs-3261431/v1" @default.
• W4386723941 hasPublicationYear "2023" @default.
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