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• W4386725539 abstract "The acquisition of distinct branch sizes and shapes is a central aspect in tubular organ morphogenesis and function. In the Drosophila airway tree, the interplay of apical extracellular matrix (ECM) components with the underlying membrane and cytoskeleton controls tube elongation, but the link between ECM composition with apical membrane morphogenesis and tube size regulation is elusive. Here, we characterized Emp (epithelial membrane protein), a Drosophila CD36 homolog belonging to the scavenger receptor class B protein family. emp mutant embryos fail to internalize the luminal chitin deacetylases Serp and Verm at the final stages of airway maturation and die at hatching with liquid filled airways. Emp localizes in apical epithelial membranes and shows cargo selectivity for LDLr-domain containing proteins. emp mutants also display over elongated tracheal tubes with increased levels of the apical proteins Crb, DE-cad, and phosphorylated Src (p-Src). We show that Emp associates with and organizes the βH-Spectrin cytoskeleton and is itself confined by apical F-actin bundles. Overexpression or loss of its cargo protein Serp lead to abnormal apical accumulations of Emp and perturbations in p-Src levels. We propose that during morphogenesis, Emp senses and responds to luminal cargo levels by initiating apical membrane endocytosis along the longitudinal tube axis and thereby restricts airway elongation." @default.
• W4386725539 created "2023-09-15" @default.
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• W4386725539 date "2023-09-14" @default.
• W4386725539 modified "2023-10-13" @default.
• W4386725539 title "Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways" @default.
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• W4386725539 doi "https://doi.org/10.7554/elife.84974" @default.
• W4386725539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37706489" @default.
• W4386725539 hasPublicationYear "2023" @default.
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