FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386726586> ?p ?o ?g. }

• W4386726586 abstract "Delay in diagnosing multidrug-resistant tuberculosis (MDR-pTB) in children prolongs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case-control study to analyze MDR-pTB cases in Germany between 2010 and 2020 in comparison to a drug-susceptible (DS)-pTB group. We included 52 MDR cases (24 tuberculosis (TB), 28 TB infection (TBI); mean age 7.3 years) and 56 DS cases (31 TB, 26 TBI; mean age 7.9 years). Groups were similar for sex, household size, and migration background. Compared to the DS group, more children with MDR were born in the Commonwealth of Independent States (CIS) (22% MDR-pTB vs. 13% DS-pTB, n.s.) and had more MDR index cases (94% MDR-pTB, 5% DS-pTB, p < 0.001). The interval between first healthcare contact and initiation of effective therapy was significantly longer in MDR-pTB (47 days) than in DS-pTB (11 days, p < 0.001), correlating with disease progression. Treatment for MDR-pTB was successful in 74%, but 22% experienced long-term adverse effects (e.g., hepatopathy, hearing loss).Close contact to MDR cases or birth in MDR-TB-high-incidence countries are risk factors for MDR-pTB. Early identification of potential MDR index cases by contact investigation, and susceptibility testing in children from high-burden MDR-TB countries are essential for timely diagnosis and treatment, reducing the severity of disease and treatment side effects.Deutsches Register Klinischer Studien ( https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00023817 ), DRKS00023817, 2020-09-08.•Management of children with MDR-TB remains challenging due to difficulties in diagnosing MDR-TB (lack of information on MDR index case, lack of microbiological confirmation in paucibacillary disease). •Choice of treatment regimen and monitoring of side effects.•Children with an MDR-TB index or born in a MDR-TB-high-incidence country are at higher risk of developing MDR-TB in a low incidence country. •The time lag to initiate treatment in MDR-TB is longer than in DS-TB and MDR-TB treatment involves a higher risk of adverse effects in longer treatment regimens especially with injectables." @default.
• W4386726586 created "2023-09-15" @default.
• W4386726586 creator A5002977923 @default.
• W4386726586 creator A5010258550 @default.
• W4386726586 creator A5010719426 @default.
• W4386726586 creator A5010813772 @default.
• W4386726586 creator A5012057708 @default.
• W4386726586 creator A5014863551 @default.
• W4386726586 creator A5015843387 @default.
• W4386726586 creator A5035488578 @default.
• W4386726586 creator A5038599889 @default.
• W4386726586 creator A5040457874 @default.
• W4386726586 creator A5041597675 @default.
• W4386726586 creator A5061188473 @default.
• W4386726586 creator A5073988210 @default.
• W4386726586 creator A5079174367 @default.
• W4386726586 creator A5084460362 @default.
• W4386726586 creator A5089485313 @default.
• W4386726586 date "2023-09-14" @default.
• W4386726586 modified "2023-09-26" @default.
• W4386726586 title "Pediatric multi-drug-resistant tuberculosis in Germany – diagnostic and therapeutic challenges of an “orphan disease”" @default.
• W4386726586 cites W1892652139 @default.
• W4386726586 cites W1963492099 @default.
• W4386726586 cites W2038970546 @default.
• W4386726586 cites W2115689410 @default.
• W4386726586 cites W2125052660 @default.
• W4386726586 cites W2127312599 @default.
• W4386726586 cites W2131368119 @default.
• W4386726586 cites W2147353037 @default.
• W4386726586 cites W2164091066 @default.
• W4386726586 cites W2300781968 @default.
• W4386726586 cites W2547816456 @default.
• W4386726586 cites W2552759998 @default.
• W4386726586 cites W2578932289 @default.
• W4386726586 cites W2601822049 @default.
• W4386726586 cites W2660214686 @default.
• W4386726586 cites W2744304370 @default.
• W4386726586 cites W2761187037 @default.
• W4386726586 cites W2789449967 @default.
• W4386726586 cites W2802350967 @default.
• W4386726586 cites W2855009822 @default.
• W4386726586 cites W2933196882 @default.
• W4386726586 cites W2950876717 @default.
• W4386726586 cites W2969414923 @default.
• W4386726586 cites W2973028036 @default.
• W4386726586 cites W2981859943 @default.
• W4386726586 cites W2998262099 @default.
• W4386726586 cites W2999750593 @default.
• W4386726586 cites W3008854038 @default.
• W4386726586 cites W3015309240 @default.
• W4386726586 cites W3027278503 @default.
• W4386726586 cites W3085884115 @default.
• W4386726586 cites W3089047626 @default.
• W4386726586 cites W3094483970 @default.
• W4386726586 cites W4283025503 @default.
• W4386726586 cites W4306399166 @default.
• W4386726586 cites W4309094790 @default.
• W4386726586 doi "https://doi.org/10.1007/s00431-023-05167-x" @default.
• W4386726586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37707590" @default.
• W4386726586 hasPublicationYear "2023" @default.
• W4386726586 type Work @default.
• W4386726586 citedByCount "0" @default.
• W4386726586 crossrefType "journal-article" @default.
• W4386726586 hasAuthorship W4386726586A5002977923 @default.
• W4386726586 hasAuthorship W4386726586A5010258550 @default.
• W4386726586 hasAuthorship W4386726586A5010719426 @default.
• W4386726586 hasAuthorship W4386726586A5010813772 @default.
• W4386726586 hasAuthorship W4386726586A5012057708 @default.
• W4386726586 hasAuthorship W4386726586A5014863551 @default.
• W4386726586 hasAuthorship W4386726586A5015843387 @default.
• W4386726586 hasAuthorship W4386726586A5035488578 @default.
• W4386726586 hasAuthorship W4386726586A5038599889 @default.
• W4386726586 hasAuthorship W4386726586A5040457874 @default.
• W4386726586 hasAuthorship W4386726586A5041597675 @default.
• W4386726586 hasAuthorship W4386726586A5061188473 @default.
• W4386726586 hasAuthorship W4386726586A5073988210 @default.
• W4386726586 hasAuthorship W4386726586A5079174367 @default.
• W4386726586 hasAuthorship W4386726586A5084460362 @default.
• W4386726586 hasAuthorship W4386726586A5089485313 @default.
• W4386726586 hasBestOaLocation W43867265861 @default.
• W4386726586 hasConcept C114851261 @default.
• W4386726586 hasConcept C120665830 @default.
• W4386726586 hasConcept C121332964 @default.
• W4386726586 hasConcept C126322002 @default.
• W4386726586 hasConcept C133936738 @default.
• W4386726586 hasConcept C142724271 @default.
• W4386726586 hasConcept C167135981 @default.
• W4386726586 hasConcept C187212893 @default.
• W4386726586 hasConcept C2777107064 @default.
• W4386726586 hasConcept C2777975735 @default.
• W4386726586 hasConcept C2779134260 @default.
• W4386726586 hasConcept C2781069245 @default.
• W4386726586 hasConcept C61511704 @default.
• W4386726586 hasConcept C71924100 @default.
• W4386726586 hasConcept C86803240 @default.
• W4386726586 hasConcept C89423630 @default.
• W4386726586 hasConceptScore W4386726586C114851261 @default.
• W4386726586 hasConceptScore W4386726586C120665830 @default.
• W4386726586 hasConceptScore W4386726586C121332964 @default.
• W4386726586 hasConceptScore W4386726586C126322002 @default.

• next