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- W4386727006 abstract "ABSTRACT We focused on Piper longum L., a herbal drug produced in Myanmar, which has a renoprotective effect. Thus, we attempted to isolate and identify compounds that enhance the expression of the ABCG2 gene from the aerial parts of the plant except for the fruit. Among the various P. longum extracts, we isolated and identified the components. Using Caco-2 cells, the hABCG2 mRNA expression-enhancing effects of the isolated compounds were compared with the positive reference compound (3-methylcholanthrene [3MC]) using real-time polymerase chain reaction. Six compounds were isolated and identified from the methanol extract of P. longum. Among the isolated compounds, licarin A and neopomatene had lower toxicity and higher hABCG2 mRNA expression-enhancing effects in Caco-2 cells. Suppression of hAhR expression by siRNA reduced the activity of licarin A and neopomatene, as well as the hAhR agonist 3MC, suggesting that these 2 compounds may act as hAhR agonists to promote hABCG2 expression." @default.
- W4386727006 created "2023-09-15" @default.
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- W4386727006 date "2023-09-14" @default.
- W4386727006 modified "2023-10-18" @default.
- W4386727006 title "Promotion of ABCG2 gene expression by neolignans from <i>Piper longum</i> L." @default.
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- W4386727006 doi "https://doi.org/10.1093/bbb/zbad132" @default.
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