FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386731055> ?p ?o ?g. }

• W4386731055 abstract "Hind limbs of tetrapods vary greatly in length and the variability can be associated with locomotor adaptation. Although the phenotypic evolution has been well documented, the underlying genetic basis remains poorly understood. We address this issue by integrating comparative genomics and functional prediction with a study system consisting of ground-dwelling, long-legged and tree-dwelling, short-legged species within the avian family Paridae. Genome-wide divergence and phenotypic correlation analyses jointly identified five highly divergent genomic regions that are significantly related with the difference in leg length between these two groups. Gene annotation for these regions detected three genes involved in skeletal development, that is, PTPA, BRINP1, and MIGA2, with the first one being under the strongest selection. Furthermore, four single nucleotide polymorphisms (SNPs) in the coding region of PTPA can well distinguish the two groups with distinct leg length. Among the four SNPs, one is non-synonymous mutation, and according to the prediction for protein structure and function, it can affect the 3D structure of the encoded protein by altering the corresponding amino acid's position. The alleles of PTPA were found in all sequenced species of the orders Palaeognathae and Psittaciformes, which typically take a ground locomotion style. A whole-genome scanning across bird species uncovered that the four SNPs are more likely to be present in resident passerines with increased leg length/wing length ratios (a proxy of leg-dependent locomotion efficiency). Our findings provide insight into the molecular evolution of locomotion performance based on leg morphology in birds." @default.
• W4386731055 created "2023-09-15" @default.
• W4386731055 creator A5019751079 @default.
• W4386731055 creator A5028865159 @default.
• W4386731055 creator A5056901438 @default.
• W4386731055 date "2023-09-01" @default.
• W4386731055 modified "2023-09-27" @default.
• W4386731055 title "Genomic basis of adaptive divergence in leg length between ground- and tree-dwelling species within a bird family" @default.
• W4386731055 cites W1583755227 @default.
• W4386731055 cites W1749662549 @default.
• W4386731055 cites W1965169340 @default.
• W4386731055 cites W1965792380 @default.
• W4386731055 cites W1999038459 @default.
• W4386731055 cites W2007084552 @default.
• W4386731055 cites W2016067228 @default.
• W4386731055 cites W2018581055 @default.
• W4386731055 cites W2024405748 @default.
• W4386731055 cites W2031286849 @default.
• W4386731055 cites W2055043387 @default.
• W4386731055 cites W2076220903 @default.
• W4386731055 cites W2084457999 @default.
• W4386731055 cites W2096585111 @default.
• W4386731055 cites W2103441770 @default.
• W4386731055 cites W2106578986 @default.
• W4386731055 cites W2112348586 @default.
• W4386731055 cites W2112358885 @default.
• W4386731055 cites W2117210943 @default.
• W4386731055 cites W2119180969 @default.
• W4386731055 cites W2127779696 @default.
• W4386731055 cites W2129949334 @default.
• W4386731055 cites W2131271579 @default.
• W4386731055 cites W2132393729 @default.
• W4386731055 cites W2138279862 @default.
• W4386731055 cites W2140784970 @default.
• W4386731055 cites W2146566703 @default.
• W4386731055 cites W2149992227 @default.
• W4386731055 cites W2154367724 @default.
• W4386731055 cites W2154845780 @default.
• W4386731055 cites W2158217645 @default.
• W4386731055 cites W2161633633 @default.
• W4386731055 cites W2165460624 @default.
• W4386731055 cites W2181883658 @default.
• W4386731055 cites W2185939985 @default.
• W4386731055 cites W2272717953 @default.
• W4386731055 cites W2536097271 @default.
• W4386731055 cites W2585565608 @default.
• W4386731055 cites W2615908011 @default.
• W4386731055 cites W2786174959 @default.
• W4386731055 cites W2799524357 @default.
• W4386731055 cites W3037548839 @default.
• W4386731055 cites W3042222226 @default.
• W4386731055 cites W3177828909 @default.
• W4386731055 cites W4213419599 @default.
• W4386731055 cites W4247053599 @default.
• W4386731055 cites W4291652208 @default.
• W4386731055 cites W4307656494 @default.
• W4386731055 cites W4385264130 @default.
• W4386731055 doi "https://doi.org/10.1093/gbe/evad166" @default.
• W4386731055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37708414" @default.
• W4386731055 hasPublicationYear "2023" @default.
• W4386731055 type Work @default.
• W4386731055 citedByCount "0" @default.
• W4386731055 crossrefType "journal-article" @default.
• W4386731055 hasAuthorship W4386731055A5019751079 @default.
• W4386731055 hasAuthorship W4386731055A5028865159 @default.
• W4386731055 hasAuthorship W4386731055A5056901438 @default.
• W4386731055 hasBestOaLocation W43867310551 @default.
• W4386731055 hasConcept C104317684 @default.
• W4386731055 hasConcept C105176652 @default.
• W4386731055 hasConcept C127716648 @default.
• W4386731055 hasConcept C135763542 @default.
• W4386731055 hasConcept C139807058 @default.
• W4386731055 hasConcept C141231307 @default.
• W4386731055 hasConcept C153209595 @default.
• W4386731055 hasConcept C169760540 @default.
• W4386731055 hasConcept C189206191 @default.
• W4386731055 hasConcept C54355233 @default.
• W4386731055 hasConcept C78458016 @default.
• W4386731055 hasConcept C86803240 @default.
• W4386731055 hasConceptScore W4386731055C104317684 @default.
• W4386731055 hasConceptScore W4386731055C105176652 @default.
• W4386731055 hasConceptScore W4386731055C127716648 @default.
• W4386731055 hasConceptScore W4386731055C135763542 @default.
• W4386731055 hasConceptScore W4386731055C139807058 @default.
• W4386731055 hasConceptScore W4386731055C141231307 @default.
• W4386731055 hasConceptScore W4386731055C153209595 @default.
• W4386731055 hasConceptScore W4386731055C169760540 @default.
• W4386731055 hasConceptScore W4386731055C189206191 @default.
• W4386731055 hasConceptScore W4386731055C54355233 @default.
• W4386731055 hasConceptScore W4386731055C78458016 @default.
• W4386731055 hasConceptScore W4386731055C86803240 @default.
• W4386731055 hasFunder F4320321001 @default.
• W4386731055 hasIssue "9" @default.
• W4386731055 hasLocation W43867310551 @default.
• W4386731055 hasLocation W43867310552 @default.
• W4386731055 hasOpenAccess W4386731055 @default.
• W4386731055 hasPrimaryLocation W43867310551 @default.
• W4386731055 hasRelatedWork W1531420823 @default.
• W4386731055 hasRelatedWork W2011544219 @default.
• W4386731055 hasRelatedWork W2024899437 @default.

• next