Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386732618> ?p ?o ?g. }
- W4386732618 abstract "Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is required to develop alternative therapeutic strategies.The lung fibroblasts from IPF patients and Reticulocalbin 3 (RCN3) fibroblast-selective knockdown mouse model were used to determine the importance of Rcn3 in IPF; the epigenetic analysis and protein interaction assays, including BioID, were used for mechanistic studies.Reticulocalbin 3 (RCN3) upregulation is associated with the fibrotic activation of lung fibroblasts from IPF patients and Rcn3 overexpression blunts the antifibrotic effects of pirfenidone and nintedanib. Moreover, repressing Rcn3 expression in mouse fibroblasts ameliorates bleomycin-induced lung fibrosis and pulmonary dysfunction in vivo. Mechanistically, RCN3 promotes fibroblast activation by maintaining persistent activation of TGFβ1 signalling via the TGFβ1-RCN3-TGFBR1 positive feedback loop, in which RCN3 upregulated by TGFβ1 exposure detains EZH2 (an epigenetic methyltransferase) in the cytoplasm through RCN3-EZH2 interaction, leading to the release of the EZH2-H3K27me3 epigenetic repression of TGFBR1 and the persistent expression of TGFBR1.These findings introduce a novel regulating mechanism of TGFβ1 signalling in fibroblasts and uncover a critical role of the RCN3-mediated loop in lung fibrosis. RCN3 upregulation may cause resistance to IPF treatment and targeting RCN3 could be a novel approach to ameliorate pulmonary fibrosis." @default.
- W4386732618 created "2023-09-15" @default.
- W4386732618 creator A5011270948 @default.
- W4386732618 creator A5012111555 @default.
- W4386732618 creator A5023652001 @default.
- W4386732618 creator A5034615694 @default.
- W4386732618 creator A5037677450 @default.
- W4386732618 creator A5050004690 @default.
- W4386732618 creator A5054199213 @default.
- W4386732618 creator A5059305131 @default.
- W4386732618 creator A5061566488 @default.
- W4386732618 creator A5063330461 @default.
- W4386732618 creator A5064530138 @default.
- W4386732618 creator A5072382248 @default.
- W4386732618 creator A5074042731 @default.
- W4386732618 creator A5082809342 @default.
- W4386732618 date "2023-09-14" @default.
- W4386732618 modified "2023-10-06" @default.
- W4386732618 title "TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation" @default.
- W4386732618 cites W1854727002 @default.
- W4386732618 cites W1894287559 @default.
- W4386732618 cites W1989161541 @default.
- W4386732618 cites W2052677158 @default.
- W4386732618 cites W2080818814 @default.
- W4386732618 cites W2114054457 @default.
- W4386732618 cites W2115040576 @default.
- W4386732618 cites W2120791222 @default.
- W4386732618 cites W2136704317 @default.
- W4386732618 cites W2138871107 @default.
- W4386732618 cites W2140165266 @default.
- W4386732618 cites W2150639372 @default.
- W4386732618 cites W2162175607 @default.
- W4386732618 cites W2168666423 @default.
- W4386732618 cites W2599075603 @default.
- W4386732618 cites W2618920555 @default.
- W4386732618 cites W2741556950 @default.
- W4386732618 cites W2754130808 @default.
- W4386732618 cites W2762514850 @default.
- W4386732618 cites W2795718114 @default.
- W4386732618 cites W2799479598 @default.
- W4386732618 cites W2801760244 @default.
- W4386732618 cites W2804412686 @default.
- W4386732618 cites W2885411864 @default.
- W4386732618 cites W2901152891 @default.
- W4386732618 cites W2902678397 @default.
- W4386732618 cites W2984001839 @default.
- W4386732618 cites W3002376302 @default.
- W4386732618 cites W3005492466 @default.
- W4386732618 cites W3021543659 @default.
- W4386732618 cites W3041062936 @default.
- W4386732618 cites W3047214800 @default.
- W4386732618 cites W3048987312 @default.
- W4386732618 cites W3080561061 @default.
- W4386732618 cites W3112756506 @default.
- W4386732618 cites W3112996818 @default.
- W4386732618 cites W3116084499 @default.
- W4386732618 cites W3130456906 @default.
- W4386732618 cites W3132105201 @default.
- W4386732618 cites W3164943011 @default.
- W4386732618 cites W3182024781 @default.
- W4386732618 cites W3184622043 @default.
- W4386732618 cites W4210580784 @default.
- W4386732618 cites W4229446476 @default.
- W4386732618 doi "https://doi.org/10.1186/s12931-023-02533-z" @default.
- W4386732618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37710230" @default.
- W4386732618 hasPublicationYear "2023" @default.
- W4386732618 type Work @default.
- W4386732618 citedByCount "0" @default.
- W4386732618 crossrefType "journal-article" @default.
- W4386732618 hasAuthorship W4386732618A5011270948 @default.
- W4386732618 hasAuthorship W4386732618A5012111555 @default.
- W4386732618 hasAuthorship W4386732618A5023652001 @default.
- W4386732618 hasAuthorship W4386732618A5034615694 @default.
- W4386732618 hasAuthorship W4386732618A5037677450 @default.
- W4386732618 hasAuthorship W4386732618A5050004690 @default.
- W4386732618 hasAuthorship W4386732618A5054199213 @default.
- W4386732618 hasAuthorship W4386732618A5059305131 @default.
- W4386732618 hasAuthorship W4386732618A5061566488 @default.
- W4386732618 hasAuthorship W4386732618A5063330461 @default.
- W4386732618 hasAuthorship W4386732618A5064530138 @default.
- W4386732618 hasAuthorship W4386732618A5072382248 @default.
- W4386732618 hasAuthorship W4386732618A5074042731 @default.
- W4386732618 hasAuthorship W4386732618A5082809342 @default.
- W4386732618 hasBestOaLocation W43867326181 @default.
- W4386732618 hasConcept C104317684 @default.
- W4386732618 hasConcept C126322002 @default.
- W4386732618 hasConcept C127561419 @default.
- W4386732618 hasConcept C142724271 @default.
- W4386732618 hasConcept C173396325 @default.
- W4386732618 hasConcept C203014093 @default.
- W4386732618 hasConcept C2776232574 @default.
- W4386732618 hasConcept C2776694085 @default.
- W4386732618 hasConcept C2777714996 @default.
- W4386732618 hasConcept C2778341716 @default.
- W4386732618 hasConcept C2779832356 @default.
- W4386732618 hasConcept C2780171596 @default.
- W4386732618 hasConcept C2780381497 @default.
- W4386732618 hasConcept C2780559512 @default.
- W4386732618 hasConcept C2781244666 @default.
- W4386732618 hasConcept C41091548 @default.