Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386736223> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4386736223 abstract "Abstract Objective: The objective of this research is to clarify how Shenfu injection enhances chronic heart failure treatment, specifically by examining its influence on the NLRP3-Caspase-1 pathway. Methods: The chronic heart failure in rats was induced through subcutaneous administration of isoproterenol. The effectiveness of Shenfu injection was assessed by examining cardiac function using echocardiography, monitoring changes in serum N-terminal brain natriuretic peptide levels, and conducting histological analysis with HE and Masson staining to evaluate modifications in myocardial cell structure and fibrosis. To assess the protein levels associated with the NLRP3/Caspase-1 pathway, cellular pyroptosis, and myocardial ultrastructure, various techniques including Western blotting, GSDMD-N staining, TUNEL immunofluorescence dual staining, and electron microscopy were employed. Results: Shenfu injection significantly ameliorated cardiac function, myocardial arrangement, and fibrosis in chronic heart failure rats. Significantly, it substantially decreased the protein levels of NLRP3, caspase-1, IL-1β, and IL-18, along with a reduction in cellular pyroptosis positivity (P < 0.05). Under electron microscopy, the morphology appeared normal, with only partial cell membranes exhibiting pore formation. Conclusion: In summary, our research indicates that the SFI intervention improves cardiac function in the chronic heart failure model induced by isoproterenol, possibly by regulating the NLRP3/Caspase-1 pathway to reduce pyroptosis, suppress inflammatory responses, protect myocardial cells, and maintain the integrity of cellular ultrastructure." @default.
- W4386736223 created "2023-09-15" @default.
- W4386736223 creator A5012332178 @default.
- W4386736223 creator A5012721478 @default.
- W4386736223 creator A5048483256 @default.
- W4386736223 creator A5079804162 @default.
- W4386736223 creator A5084556955 @default.
- W4386736223 date "2023-09-14" @default.
- W4386736223 modified "2023-09-27" @default.
- W4386736223 title "Shenfu Injection Regulates Pyroptosis through the NLRP3/Caspase-1 Pathway to Improve Chronic Heart Failure" @default.
- W4386736223 doi "https://doi.org/10.21203/rs.3.rs-3325004/v1" @default.
- W4386736223 hasPublicationYear "2023" @default.
- W4386736223 type Work @default.
- W4386736223 citedByCount "0" @default.
- W4386736223 crossrefType "posted-content" @default.
- W4386736223 hasAuthorship W4386736223A5012332178 @default.
- W4386736223 hasAuthorship W4386736223A5012721478 @default.
- W4386736223 hasAuthorship W4386736223A5048483256 @default.
- W4386736223 hasAuthorship W4386736223A5079804162 @default.
- W4386736223 hasAuthorship W4386736223A5084556955 @default.
- W4386736223 hasBestOaLocation W43867362231 @default.
- W4386736223 hasConcept C111566952 @default.
- W4386736223 hasConcept C126322002 @default.
- W4386736223 hasConcept C158157758 @default.
- W4386736223 hasConcept C17172800 @default.
- W4386736223 hasConcept C185592680 @default.
- W4386736223 hasConcept C190283241 @default.
- W4386736223 hasConcept C196795494 @default.
- W4386736223 hasConcept C204232928 @default.
- W4386736223 hasConcept C2776914184 @default.
- W4386736223 hasConcept C2777209026 @default.
- W4386736223 hasConcept C2778198053 @default.
- W4386736223 hasConcept C2780559512 @default.
- W4386736223 hasConcept C2781175142 @default.
- W4386736223 hasConcept C55493867 @default.
- W4386736223 hasConcept C71924100 @default.
- W4386736223 hasConcept C79879829 @default.
- W4386736223 hasConcept C86803240 @default.
- W4386736223 hasConcept C95444343 @default.
- W4386736223 hasConceptScore W4386736223C111566952 @default.
- W4386736223 hasConceptScore W4386736223C126322002 @default.
- W4386736223 hasConceptScore W4386736223C158157758 @default.
- W4386736223 hasConceptScore W4386736223C17172800 @default.
- W4386736223 hasConceptScore W4386736223C185592680 @default.
- W4386736223 hasConceptScore W4386736223C190283241 @default.
- W4386736223 hasConceptScore W4386736223C196795494 @default.
- W4386736223 hasConceptScore W4386736223C204232928 @default.
- W4386736223 hasConceptScore W4386736223C2776914184 @default.
- W4386736223 hasConceptScore W4386736223C2777209026 @default.
- W4386736223 hasConceptScore W4386736223C2778198053 @default.
- W4386736223 hasConceptScore W4386736223C2780559512 @default.
- W4386736223 hasConceptScore W4386736223C2781175142 @default.
- W4386736223 hasConceptScore W4386736223C55493867 @default.
- W4386736223 hasConceptScore W4386736223C71924100 @default.
- W4386736223 hasConceptScore W4386736223C79879829 @default.
- W4386736223 hasConceptScore W4386736223C86803240 @default.
- W4386736223 hasConceptScore W4386736223C95444343 @default.
- W4386736223 hasLocation W43867362231 @default.
- W4386736223 hasOpenAccess W4386736223 @default.
- W4386736223 hasPrimaryLocation W43867362231 @default.
- W4386736223 hasRelatedWork W2314001535 @default.
- W4386736223 hasRelatedWork W2770925055 @default.
- W4386736223 hasRelatedWork W2968698979 @default.
- W4386736223 hasRelatedWork W2972371855 @default.
- W4386736223 hasRelatedWork W3001408817 @default.
- W4386736223 hasRelatedWork W3111668102 @default.
- W4386736223 hasRelatedWork W3151603839 @default.
- W4386736223 hasRelatedWork W3185847673 @default.
- W4386736223 hasRelatedWork W4213451181 @default.
- W4386736223 hasRelatedWork W4383481577 @default.
- W4386736223 isParatext "false" @default.
- W4386736223 isRetracted "false" @default.
- W4386736223 workType "article" @default.