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- W4386738468 abstract "During aging, proteostasis capacity declines and distinct proteins become unstable and can accumulate as protein aggregates inside and outside of cells. Both in disease and during aging, proteins selectively aggregate in certain tissues and not others. Yet, tissue-specific regulation of cytoplasmic protein aggregation remains poorly understood. Surprisingly, we found that the inhibition of 3 core protein quality control systems, namely chaperones, the proteasome, and macroautophagy, leads to lower levels of age-dependent protein aggregation in Caenorhabditis elegans pharyngeal muscles, but higher levels in body-wall muscles. We describe a novel safety mechanism that selectively targets newly synthesized proteins to suppress their aggregation and associated proteotoxicity. The safety mechanism relies on macroautophagy-independent lysosomal degradation and involves several previously uncharacterized components of the intracellular pathogen response (IPR). We propose that this protective mechanism engages an anti-aggregation machinery targeting aggregating proteins for lysosomal degradation." @default.
- W4386738468 created "2023-09-15" @default.
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- W4386738468 date "2023-09-14" @default.
- W4386738468 modified "2023-09-26" @default.
- W4386738468 title "A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans" @default.
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- W4386738468 cites W1974332480 @default.
- W4386738468 cites W1976080126 @default.
- W4386738468 cites W1980431043 @default.
- W4386738468 cites W1982478101 @default.
- W4386738468 cites W1988278060 @default.
- W4386738468 cites W1991017805 @default.
- W4386738468 cites W1991533918 @default.
- W4386738468 cites W2014297210 @default.
- W4386738468 cites W2022812113 @default.
- W4386738468 cites W2032462953 @default.
- W4386738468 cites W2034734284 @default.
- W4386738468 cites W2047102030 @default.
- W4386738468 cites W2050668497 @default.
- W4386738468 cites W2058127437 @default.
- W4386738468 cites W2074911710 @default.
- W4386738468 cites W2077569666 @default.
- W4386738468 cites W2089145020 @default.
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- W4386738468 cites W2136201006 @default.
- W4386738468 cites W2140729960 @default.
- W4386738468 cites W2141444248 @default.
- W4386738468 cites W2144224170 @default.
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- W4386738468 cites W2151893314 @default.
- W4386738468 cites W2158932513 @default.
- W4386738468 cites W2161463238 @default.
- W4386738468 cites W2162930176 @default.
- W4386738468 cites W2164907867 @default.
- W4386738468 cites W2166820820 @default.
- W4386738468 cites W2167235559 @default.
- W4386738468 cites W2170471048 @default.
- W4386738468 cites W2298644555 @default.
- W4386738468 cites W2401710715 @default.
- W4386738468 cites W2418801787 @default.
- W4386738468 cites W2487443016 @default.
- W4386738468 cites W2493924003 @default.
- W4386738468 cites W2537798964 @default.
- W4386738468 cites W2566975912 @default.
- W4386738468 cites W2569733750 @default.
- W4386738468 cites W2571489187 @default.
- W4386738468 cites W2587038123 @default.
- W4386738468 cites W2606353566 @default.
- W4386738468 cites W2609977986 @default.
- W4386738468 cites W2616526578 @default.
- W4386738468 cites W2617460871 @default.
- W4386738468 cites W2620843886 @default.
- W4386738468 cites W2621728938 @default.
- W4386738468 cites W2732209041 @default.
- W4386738468 cites W2760213340 @default.
- W4386738468 cites W2762137272 @default.
- W4386738468 cites W2769245250 @default.
- W4386738468 cites W2792158423 @default.
- W4386738468 cites W2795906582 @default.
- W4386738468 cites W2802760737 @default.
- W4386738468 cites W2810557289 @default.
- W4386738468 cites W2890004445 @default.
- W4386738468 cites W2890980244 @default.
- W4386738468 cites W2913940235 @default.
- W4386738468 cites W2921366582 @default.
- W4386738468 cites W2945748173 @default.
- W4386738468 cites W2950758232 @default.
- W4386738468 cites W2962216963 @default.
- W4386738468 cites W2962598558 @default.
- W4386738468 cites W3012446152 @default.
- W4386738468 cites W3036344983 @default.
- W4386738468 cites W3036883131 @default.
- W4386738468 cites W3041873466 @default.
- W4386738468 cites W3083883345 @default.
- W4386738468 cites W3154978233 @default.