FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386741764> ?p ?o ?g. }

• W4386741764 abstract "Tumor immune microenvironment regulates the growth and metastasis of uveal melanoma (UM). This study aims to reveal the possible molecular mechanism of BRCA1-associated protein 1 (BAP1) mutations in affecting the tumor immune microenvironment in UM through mediating the nuclear factor-κB (NF-κB) signaling pathway.TCGA and cBioPortal databases jointly analyzed the genes with high mutation frequency in UM samples. Following survival analysis of UM patients, UM samples with BAP1 mutations were subjected to immune cell infiltration analysis. The signaling pathways associated with the mutated genes were screened by GSEA. Subsequently, the differential BAP1 expression was analyzed in the selected UM cell lines with wild type (WT) or mutant type (MUT) BAP1.Bioinformatics analysis identified 12 genes mutated in the UM samples, while only BAP1 mutations were related to the prognosis of UM patients. UM patients with BAP1 mutations had higher immune cell infiltration. BAP1 mutations inhibited the NF-κB signaling pathway, suppressing the cytokine secretion and antigen presentation by macrophages. Rescue experiments confirmed that overexpressed NF-κB could reverse the effect of BAP1 mutations on the immunosuppressive microenvironment, thus suppressing the malignant phenotypes of UM cells.BAP1 mutations may inhibit the NF-κB signaling pathway, repressing the cytokine secretion and antigen presentation by macrophages, which induces the immunosuppressive microenvironment, enhances the malignant phenotypes of UM cells and ultimately promotes the growth and metastasis of UM." @default.
• W4386741764 created "2023-09-15" @default.
• W4386741764 creator A5047468611 @default.
• W4386741764 creator A5089966579 @default.
• W4386741764 date "2023-09-14" @default.
• W4386741764 modified "2023-10-15" @default.
• W4386741764 title "BAP1 mutations inhibit the NF-κB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma" @default.
• W4386741764 cites W1982418699 @default.
• W4386741764 cites W1990403579 @default.
• W4386741764 cites W2060610804 @default.
• W4386741764 cites W2169729757 @default.
• W4386741764 cites W2300492004 @default.
• W4386741764 cites W2468768867 @default.
• W4386741764 cites W2789955711 @default.
• W4386741764 cites W2803410910 @default.
• W4386741764 cites W2901247462 @default.
• W4386741764 cites W2912628568 @default.
• W4386741764 cites W2955441129 @default.
• W4386741764 cites W2963590143 @default.
• W4386741764 cites W2964812729 @default.
• W4386741764 cites W2976161620 @default.
• W4386741764 cites W2999524633 @default.
• W4386741764 cites W3002671583 @default.
• W4386741764 cites W3005402331 @default.
• W4386741764 cites W3006979872 @default.
• W4386741764 cites W3036958184 @default.
• W4386741764 cites W3040139547 @default.
• W4386741764 cites W3054433483 @default.
• W4386741764 cites W3091384409 @default.
• W4386741764 cites W3094337094 @default.
• W4386741764 cites W3098604035 @default.
• W4386741764 cites W3131620481 @default.
• W4386741764 cites W3133880687 @default.
• W4386741764 cites W3177764394 @default.
• W4386741764 cites W4206773095 @default.
• W4386741764 cites W4210668401 @default.
• W4386741764 cites W4211020617 @default.
• W4386741764 cites W4212882142 @default.
• W4386741764 cites W4214503874 @default.
• W4386741764 cites W4223906497 @default.
• W4386741764 cites W4225548402 @default.
• W4386741764 cites W4280622858 @default.
• W4386741764 cites W4280625651 @default.
• W4386741764 cites W4288441466 @default.
• W4386741764 cites W4366978109 @default.
• W4386741764 doi "https://doi.org/10.1186/s10020-023-00713-7" @default.
• W4386741764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37710185" @default.
• W4386741764 hasPublicationYear "2023" @default.
• W4386741764 type Work @default.
• W4386741764 citedByCount "0" @default.
• W4386741764 crossrefType "journal-article" @default.
• W4386741764 hasAuthorship W4386741764A5047468611 @default.
• W4386741764 hasAuthorship W4386741764A5089966579 @default.
• W4386741764 hasBestOaLocation W43867417641 @default.
• W4386741764 hasConcept C104317684 @default.
• W4386741764 hasConcept C127716648 @default.
• W4386741764 hasConcept C203014093 @default.
• W4386741764 hasConcept C2776090121 @default.
• W4386741764 hasConcept C2776107976 @default.
• W4386741764 hasConcept C2777658100 @default.
• W4386741764 hasConcept C2778690821 @default.
• W4386741764 hasConcept C37846818 @default.
• W4386741764 hasConcept C502942594 @default.
• W4386741764 hasConcept C54355233 @default.
• W4386741764 hasConcept C62478195 @default.
• W4386741764 hasConcept C83464605 @default.
• W4386741764 hasConcept C86803240 @default.
• W4386741764 hasConcept C8891405 @default.
• W4386741764 hasConcept C95444343 @default.
• W4386741764 hasConceptScore W4386741764C104317684 @default.
• W4386741764 hasConceptScore W4386741764C127716648 @default.
• W4386741764 hasConceptScore W4386741764C203014093 @default.
• W4386741764 hasConceptScore W4386741764C2776090121 @default.
• W4386741764 hasConceptScore W4386741764C2776107976 @default.
• W4386741764 hasConceptScore W4386741764C2777658100 @default.
• W4386741764 hasConceptScore W4386741764C2778690821 @default.
• W4386741764 hasConceptScore W4386741764C37846818 @default.
• W4386741764 hasConceptScore W4386741764C502942594 @default.
• W4386741764 hasConceptScore W4386741764C54355233 @default.
• W4386741764 hasConceptScore W4386741764C62478195 @default.
• W4386741764 hasConceptScore W4386741764C83464605 @default.
• W4386741764 hasConceptScore W4386741764C86803240 @default.
• W4386741764 hasConceptScore W4386741764C8891405 @default.
• W4386741764 hasConceptScore W4386741764C95444343 @default.
• W4386741764 hasIssue "1" @default.
• W4386741764 hasLocation W43867417641 @default.
• W4386741764 hasLocation W43867417642 @default.
• W4386741764 hasOpenAccess W4386741764 @default.
• W4386741764 hasPrimaryLocation W43867417641 @default.
• W4386741764 hasRelatedWork W2047209980 @default.
• W4386741764 hasRelatedWork W2099293633 @default.
• W4386741764 hasRelatedWork W2154152846 @default.
• W4386741764 hasRelatedWork W2327245314 @default.
• W4386741764 hasRelatedWork W2774165137 @default.
• W4386741764 hasRelatedWork W2888837017 @default.
• W4386741764 hasRelatedWork W3085168500 @default.
• W4386741764 hasRelatedWork W4223906497 @default.
• W4386741764 hasRelatedWork W2185732136 @default.
• W4386741764 hasRelatedWork W2396811992 @default.
• W4386741764 hasVolume "29" @default.

• next