FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386743478> ?p ?o ?g. }

• W4386743478 abstract "Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)), and risk loci jointly associated with ASD and the cognitive traits. We analyzed data from genome-wide association studies (GWAS) of INT (n = 269,867), EDU (n = 766,345) and ASD (cases n = 18,381, controls n = 27,969). We used the bivariate causal mixture model (MiXeR) to estimate the total number of shared genetic variants, local analysis of co-variant annotation (LAVA) to estimate local genetic correlations, conditional false discovery rate (cond/conjFDR) to identify specific overlapping loci. The MiXeR analyses showed that 12.7k genetic variants are associated with ASD, of which 12.0k variants are shared with EDU, and 11.1k are shared with INT with both positive and negative relationships within overlapping variants. The majority (59-68%) of estimated shared loci have concordant effect directions, with a positive, albeit modest, genetic correlation between ASD and EDU (rg = 0.21, p = 2e-13) and INT (rg = 0.22, p = 4e-12). We discovered 43 loci jointly associated with ASD and cognitive traits (conjFDR<0.05), of which 27 were novel for ASD. Functional analysis revealed significant differential expression of candidate genes in the cerebellum and frontal cortex. To conclude, we quantified the genetic architecture shared between ASD and cognitive traits, demonstrated mixed effect directions, and identified the associated genetic loci and molecular pathways. The findings suggest that common genetic risk factors for ASD can underlie both better and worse cognitive functioning across the ASD spectrum, with different underlying biology." @default.
• W4386743478 created "2023-09-15" @default.
• W4386743478 creator A5001909807 @default.
• W4386743478 creator A5021656534 @default.
• W4386743478 creator A5022164078 @default.
• W4386743478 creator A5028089508 @default.
• W4386743478 creator A5036630445 @default.
• W4386743478 creator A5042733882 @default.
• W4386743478 creator A5049043906 @default.
• W4386743478 creator A5052826567 @default.
• W4386743478 creator A5058922815 @default.
• W4386743478 creator A5064324947 @default.
• W4386743478 creator A5068749110 @default.
• W4386743478 creator A5073108460 @default.
• W4386743478 creator A5073483045 @default.
• W4386743478 creator A5081056837 @default.
• W4386743478 creator A5084649001 @default.
• W4386743478 creator A5092871652 @default.
• W4386743478 creator A5092871653 @default.
• W4386743478 date "2023-09-14" @default.
• W4386743478 modified "2023-10-12" @default.
• W4386743478 title "Bidirectional genetic overlap between autism spectrum disorder and cognitive traits" @default.
• W4386743478 cites W1517391732 @default.
• W4386743478 cites W1855058198 @default.
• W4386743478 cites W1894116469 @default.
• W4386743478 cites W1971321176 @default.
• W4386743478 cites W1980991473 @default.
• W4386743478 cites W1989369404 @default.
• W4386743478 cites W1989764690 @default.
• W4386743478 cites W1996024251 @default.
• W4386743478 cites W2008627757 @default.
• W4386743478 cites W2016575029 @default.
• W4386743478 cites W2022783751 @default.
• W4386743478 cites W2045227722 @default.
• W4386743478 cites W2072408668 @default.
• W4386743478 cites W2075636510 @default.
• W4386743478 cites W2087244259 @default.
• W4386743478 cites W2121585268 @default.
• W4386743478 cites W2129475546 @default.
• W4386743478 cites W2145439917 @default.
• W4386743478 cites W2153860431 @default.
• W4386743478 cites W2168610467 @default.
• W4386743478 cites W2168950294 @default.
• W4386743478 cites W2195783463 @default.
• W4386743478 cites W2405446081 @default.
• W4386743478 cites W2416912299 @default.
• W4386743478 cites W2470044734 @default.
• W4386743478 cites W2470385410 @default.
• W4386743478 cites W2556683042 @default.
• W4386743478 cites W2559028527 @default.
• W4386743478 cites W2622753418 @default.
• W4386743478 cites W2723723801 @default.
• W4386743478 cites W2757581422 @default.
• W4386743478 cites W2761275051 @default.
• W4386743478 cites W2762625022 @default.
• W4386743478 cites W2767035585 @default.
• W4386743478 cites W2770092353 @default.
• W4386743478 cites W2800160848 @default.
• W4386743478 cites W2807980527 @default.
• W4386743478 cites W2809091619 @default.
• W4386743478 cites W2809193491 @default.
• W4386743478 cites W2883573930 @default.
• W4386743478 cites W2888826705 @default.
• W4386743478 cites W2891683559 @default.
• W4386743478 cites W2908277573 @default.
• W4386743478 cites W2914482125 @default.
• W4386743478 cites W2927010782 @default.
• W4386743478 cites W2944337623 @default.
• W4386743478 cites W2947677934 @default.
• W4386743478 cites W2951333420 @default.
• W4386743478 cites W2959289532 @default.
• W4386743478 cites W2972730029 @default.
• W4386743478 cites W2977699704 @default.
• W4386743478 cites W2991335576 @default.
• W4386743478 cites W3009509870 @default.
• W4386743478 cites W3022652372 @default.
• W4386743478 cites W3027067706 @default.
• W4386743478 cites W3031509652 @default.
• W4386743478 cites W3035254462 @default.
• W4386743478 cites W3048963302 @default.
• W4386743478 cites W3080807263 @default.
• W4386743478 cites W3097014721 @default.
• W4386743478 cites W3098311027 @default.
• W4386743478 cites W3112076055 @default.
• W4386743478 cites W3116836600 @default.
• W4386743478 cites W3118910200 @default.
• W4386743478 cites W3122017685 @default.
• W4386743478 cites W3126085667 @default.
• W4386743478 cites W3181901321 @default.
• W4386743478 cites W3190968025 @default.
• W4386743478 cites W3205305359 @default.
• W4386743478 cites W3214107677 @default.
• W4386743478 cites W3216151710 @default.
• W4386743478 cites W4210606713 @default.
• W4386743478 cites W4220764353 @default.
• W4386743478 cites W4281618351 @default.
• W4386743478 cites W4313579004 @default.
• W4386743478 cites W4361190068 @default.
• W4386743478 doi "https://doi.org/10.1038/s41398-023-02563-7" @default.
• W4386743478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37709755" @default.

• next