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• W4386743504 abstract "Abstract The peroxidation of membrane lipids by free radicals contributes to aging, numerous diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the structure, conformation and physicochemical properties of lipids, leading to major membrane alterations including bilayer thinning, altered fluidity, and increased permeability. Whether and how lipid peroxidation impacts the lateral organization of proteins and lipids in biological membranes, however, remains poorly understood. Here, we employ cell-derived giant plasma membrane vesicles (GPMVs) as a model to investigate the impact of lipid peroxidation on ordered membrane domains, often termed membrane rafts. We show that lipid peroxidation induced by the Fenton reaction dramatically enhances phase separation propensity of GPMVs into co-existing liquid ordered (raft) and liquid disordered (non-raft) domains and increases the relative abundance of the disordered, non-raft phase. Peroxidation also leads to preferential accumulation of peroxidized lipids and 4-hydroxynonenal (4-HNE) adducts in the disordered phase, decreased lipid packing in both raft and non-raft domains, and translocation of multiple classes of proteins out of rafts. These findings indicate that peroxidation of plasma membrane lipids disturbs many aspects of membrane rafts, including their stability, abundance, packing, and protein and lipid composition. We propose that these disruptions contribute to the pathological consequences of lipid peroxidation during aging and disease, and thus serve as potential targets for therapeutic intervention." @default.
• W4386743504 created "2023-09-15" @default.
• W4386743504 creator A5038305596 @default.
• W4386743504 creator A5041313807 @default.
• W4386743504 date "2023-09-14" @default.
• W4386743504 modified "2023-10-05" @default.
• W4386743504 title "Lipid peroxidation drives liquid-liquid phase separation and disrupts raft protein partitioning in biological membranes" @default.
• W4386743504 cites W1543530330 @default.
• W4386743504 cites W1559606020 @default.
• W4386743504 cites W1832881993 @default.
• W4386743504 cites W1954454186 @default.
• W4386743504 cites W1963728493 @default.
• W4386743504 cites W1965464838 @default.
• W4386743504 cites W1971538731 @default.
• W4386743504 cites W1973863710 @default.
• W4386743504 cites W1974642006 @default.
• W4386743504 cites W1975696535 @default.
• W4386743504 cites W1978683809 @default.
• W4386743504 cites W1980934355 @default.
• W4386743504 cites W1989995843 @default.
• W4386743504 cites W1992782534 @default.
• W4386743504 cites W1994560929 @default.
• W4386743504 cites W1995584517 @default.
• W4386743504 cites W1998039745 @default.
• W4386743504 cites W1998520778 @default.
• W4386743504 cites W2007396482 @default.
• W4386743504 cites W2012326456 @default.
• W4386743504 cites W2013787559 @default.
• W4386743504 cites W2014218268 @default.
• W4386743504 cites W2014503023 @default.
• W4386743504 cites W2016686931 @default.
• W4386743504 cites W2018343146 @default.
• W4386743504 cites W2020099839 @default.
• W4386743504 cites W2021882008 @default.
• W4386743504 cites W2025639892 @default.
• W4386743504 cites W2028142995 @default.
• W4386743504 cites W2032762758 @default.
• W4386743504 cites W2033722815 @default.
• W4386743504 cites W2034888385 @default.
• W4386743504 cites W2035697025 @default.
• W4386743504 cites W2045992567 @default.
• W4386743504 cites W2047871652 @default.
• W4386743504 cites W2048086807 @default.
• W4386743504 cites W2048718653 @default.
• W4386743504 cites W2048888109 @default.
• W4386743504 cites W2056788990 @default.
• W4386743504 cites W2059807927 @default.
• W4386743504 cites W2060035882 @default.
• W4386743504 cites W2060688826 @default.
• W4386743504 cites W2060950196 @default.
• W4386743504 cites W2061023907 @default.
• W4386743504 cites W2069157558 @default.
• W4386743504 cites W2072274588 @default.
• W4386743504 cites W2074046123 @default.
• W4386743504 cites W2075289114 @default.
• W4386743504 cites W2076519801 @default.
• W4386743504 cites W2077159704 @default.
• W4386743504 cites W2078991664 @default.
• W4386743504 cites W2091700119 @default.
• W4386743504 cites W2093666938 @default.
• W4386743504 cites W2097261471 @default.
• W4386743504 cites W2101873758 @default.
• W4386743504 cites W2111989705 @default.
• W4386743504 cites W2117669252 @default.
• W4386743504 cites W2124947642 @default.
• W4386743504 cites W2132674183 @default.
• W4386743504 cites W2136558879 @default.
• W4386743504 cites W2138015656 @default.
• W4386743504 cites W2139296284 @default.
• W4386743504 cites W2144710665 @default.
• W4386743504 cites W2144822024 @default.
• W4386743504 cites W2153400793 @default.
• W4386743504 cites W2153776880 @default.
• W4386743504 cites W2157307148 @default.
• W4386743504 cites W2159518687 @default.
• W4386743504 cites W2171909837 @default.
• W4386743504 cites W2189205651 @default.
• W4386743504 cites W2204663410 @default.
• W4386743504 cites W2228899568 @default.
• W4386743504 cites W2285244397 @default.
• W4386743504 cites W2313623864 @default.
• W4386743504 cites W2342695013 @default.
• W4386743504 cites W2409520759 @default.
• W4386743504 cites W2501590294 @default.
• W4386743504 cites W2558761935 @default.
• W4386743504 cites W2568732189 @default.
• W4386743504 cites W2590568317 @default.
• W4386743504 cites W2599649240 @default.
• W4386743504 cites W2765136589 @default.
• W4386743504 cites W2766014895 @default.
• W4386743504 cites W2791264255 @default.
• W4386743504 cites W2792458540 @default.
• W4386743504 cites W2794652227 @default.
• W4386743504 cites W2801994775 @default.
• W4386743504 cites W2803347838 @default.
• W4386743504 cites W2891299437 @default.
• W4386743504 cites W2896610842 @default.
• W4386743504 cites W2902912836 @default.
• W4386743504 cites W2907533178 @default.
• W4386743504 cites W2912303937 @default.

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