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- W4386743537 abstract "Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease affecting the peripheral nervous system, is associated with an extremely large disease burden, and there is an increasing and urgent need for new therapies for treating this disorder. In this review we have highlighted therapeutic targets that may be translated into disease modifying therapies for PNP associated with peripheral neuropathy. We have also discussed how genetic studies and novel technologies, such as optogenetics, chemogenetics and single-cell RNA-sequencing, have been increasingly successful in revealing novel mechanisms underlying PNP. Additionally, consideration of the role of non-neuronal cells and communication between the skin and sensory afferents is presented to highlight the potential use of drug treatment that could be applied topically, bypassing drug side effects. We conclude by discussing the current difficulties to the development of effective new therapies and, most importantly, how we might improve the translation of targets for peripheral neuropathic pain identified from studies in animal models to the clinic." @default.
- W4386743537 created "2023-09-15" @default.
- W4386743537 creator A5024090738 @default.
- W4386743537 creator A5061375376 @default.
- W4386743537 creator A5072064578 @default.
- W4386743537 creator A5080827602 @default.
- W4386743537 date "2023-09-14" @default.
- W4386743537 modified "2023-10-17" @default.
- W4386743537 title "Peripheral mechanisms of peripheral neuropathic pain" @default.
- W4386743537 cites W1482298951 @default.
- W4386743537 cites W1540607329 @default.
- W4386743537 cites W1636266133 @default.
- W4386743537 cites W1855819037 @default.
- W4386743537 cites W1873187871 @default.
- W4386743537 cites W1965018866 @default.
- W4386743537 cites W1965404941 @default.
- W4386743537 cites W1966403223 @default.
- W4386743537 cites W1972242861 @default.
- W4386743537 cites W1975312927 @default.
- W4386743537 cites W1981120831 @default.
- W4386743537 cites W1981459288 @default.
- W4386743537 cites W1981478938 @default.
- W4386743537 cites W1981669433 @default.
- W4386743537 cites W1984295914 @default.
- W4386743537 cites W1984950953 @default.
- W4386743537 cites W1985689777 @default.
- W4386743537 cites W1986213783 @default.
- W4386743537 cites W1989381643 @default.
- W4386743537 cites W1990665009 @default.
- W4386743537 cites W1997333327 @default.
- W4386743537 cites W1997393571 @default.
- W4386743537 cites W1998780354 @default.
- W4386743537 cites W2016369260 @default.
- W4386743537 cites W2017221863 @default.
- W4386743537 cites W2018459912 @default.
- W4386743537 cites W2018707257 @default.
- W4386743537 cites W2019029520 @default.
- W4386743537 cites W2020098484 @default.
- W4386743537 cites W2026702352 @default.
- W4386743537 cites W2027642651 @default.
- W4386743537 cites W2029105646 @default.
- W4386743537 cites W2033072655 @default.
- W4386743537 cites W2036657358 @default.
- W4386743537 cites W2037355835 @default.
- W4386743537 cites W2040831152 @default.
- W4386743537 cites W2043406394 @default.
- W4386743537 cites W2046067515 @default.
- W4386743537 cites W2048360724 @default.
- W4386743537 cites W2049646029 @default.
- W4386743537 cites W2050725524 @default.
- W4386743537 cites W2051960468 @default.
- W4386743537 cites W2052661167 @default.
- W4386743537 cites W2056439165 @default.
- W4386743537 cites W2059524959 @default.
- W4386743537 cites W2062169143 @default.
- W4386743537 cites W2062200458 @default.
- W4386743537 cites W2064815668 @default.
- W4386743537 cites W2065018825 @default.
- W4386743537 cites W2067841051 @default.
- W4386743537 cites W2071650900 @default.
- W4386743537 cites W2075715972 @default.
- W4386743537 cites W2081791223 @default.
- W4386743537 cites W2085167864 @default.
- W4386743537 cites W2085332935 @default.
- W4386743537 cites W2087042369 @default.
- W4386743537 cites W2089172399 @default.
- W4386743537 cites W2091746433 @default.
- W4386743537 cites W2092340811 @default.
- W4386743537 cites W2092384988 @default.
- W4386743537 cites W2097699861 @default.
- W4386743537 cites W2104056153 @default.
- W4386743537 cites W2104818454 @default.
- W4386743537 cites W2105042598 @default.
- W4386743537 cites W2107063571 @default.
- W4386743537 cites W2112670171 @default.
- W4386743537 cites W2114546997 @default.
- W4386743537 cites W2117222104 @default.
- W4386743537 cites W2118866905 @default.
- W4386743537 cites W2119702217 @default.
- W4386743537 cites W2119893163 @default.
- W4386743537 cites W2120411432 @default.
- W4386743537 cites W2122571652 @default.
- W4386743537 cites W2127894556 @default.
- W4386743537 cites W2128202887 @default.
- W4386743537 cites W2129155568 @default.
- W4386743537 cites W2130496291 @default.
- W4386743537 cites W2131673631 @default.
- W4386743537 cites W2134905207 @default.
- W4386743537 cites W2135128917 @default.
- W4386743537 cites W2135900115 @default.
- W4386743537 cites W2141005071 @default.
- W4386743537 cites W2145947130 @default.
- W4386743537 cites W2149290144 @default.
- W4386743537 cites W2149573463 @default.
- W4386743537 cites W2151301539 @default.
- W4386743537 cites W2151515134 @default.
- W4386743537 cites W2151917482 @default.
- W4386743537 cites W2152111896 @default.
- W4386743537 cites W2152963050 @default.
- W4386743537 cites W2155524482 @default.