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• W4386744143 abstract "Background: Oral squamous cell carcinoma (OSCC) is the most common malignant epithelial neoplasm affecting the oral cavity. It is the third-most common cancer in India. Several human leukocyte antigen (HLA) types are associated with an increased risk of various immunologically mediated diseases. There is also evidence that the HLA gene complex may mediate susceptibility to or protection from malignancies. Various studies have been conducted worldwide, but there is a paucity of literature in India regarding the association of HLA alleles in oral squamous cell carcinoma patients. In our study, HLA class I (HLA-A and HLA-B) alleles and class II (HLA-DR) alleles were determined in 100 patients with OSCC and an equal number of healthy controls (100) were taken for comparison. DNA was extracted with Innotrain kit, and HLA typing was performed with Fluogene. Data were analyzed using SPSS software version 21.0. Aims: To study the association of HLA-A, HLA-B AND HLA-DR alleles in oral squamous cell carcinomas and its correlation with clinical staging. Objectives: 1. To compare the HLA-A, HLA-B and HLA-DR alleles in oral squamous cell carcinoma patients with healthy controls. 2. To correlate HLA-A, HLA-B, HLA-DR aleles with clinical staging of oral squamous cell carcinoma. Materials and Methods: The study was a cross sectional study conducted in the Department of Pathology and Department of Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. Blood samples of 100 histologically diagnosed cases of oral squamous cell carcinoma and 100 random healthy age and sex matched controls were chosen. Results: All the cases were compared with the healthy controls, and the data were correlated with the clinical stage of the oral squamous cell carcinoma. HLA-A * 02, HLA-A * 24, HLA-B * 15, HLA-B * 40, HLA-B * 52, HLA-DRB1 * 07, and HLA-DRB1 * 15 alleles were found to have a higher frequency than in controls and were frequently found associated with clinical Stage III of these carcinomas. Conclusion: Thus, this study helps us to establish the possible relationship between HLA-A, B, and DR alleles in oral squamous cell carcinomapatients and its correlation with clinical staging, about which there is paucity in the Indian literature to the best of our knowledge." @default.
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• W4386744143 date "2023-01-01" @default.
• W4386744143 modified "2023-09-26" @default.
• W4386744143 title "Association of HLA-A, HLA-B, and HLA-DR alleles in oral squamous cell carcinomas and its correlation with clinical staging" @default.
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• W4386744143 doi "https://doi.org/10.4103/ijohs.ijohs_21_22" @default.
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