Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386745137> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4386745137 abstract "Abstract Background One of the most popular anti-inflammatory and anti-leukemic medications is 6-mercaptopurine, along with its riboside derivatives. Because of their potent adverse effects and limited biological half-life, they are rarely used. These problems might be solved by a novel medication delivery technique based on gold nanoparticles (AuNPs). In present work, gold/chitosan nanohybrid was manufactured and assessed for photothermal therapy as well as a drug carrier to minimize the unwanted harmful effects of 6-Mercaptopurine (6-MP). We estimate loading of 6-MP on gold nanoparticles by chitosan reduction (Au@CS NPs) creating (Au@CS-6MP). Results AuNPs were green sensitized in one step via chitosan. UV–visible spectroscopy, Zeta potential, TEM, FTIR spectroscopy, and HPLC technique for loading efficiency were used to characterize AuNPs and Au@CS-6MPC NPS. Our results estimate that AuNPs and Au@CS-6MPC NPS with small sizes of 16 ± 2 and 20 ± 4 nm, respectively, and Zeta potential 53.6 ± 5.2 and 55 ± 3 mV, respectively, and loading efficiency of 52% were achieved. Cytotoxicity of the Au@CS-6MPC NPs was significantly increased compared to free 6MP with IC 50 1.11 µM. Cell viability was inhibited in AuNPs exposed to DPSS laser light, reaching 10% inhibition after 8 min. Conclusions The prepared Au@CS-6MPC NPs resulted in an additive effect in therapeutic managing of breast cancer. It can be predicted that this nanocomposite along with synergistic effect of laser light will definitely result in better therapeutic efficacy and reduced side effects of 6-MP in a combination photothermal chemotherapy treatment. This combination can be explored as future alternative for cancer therapy." @default.
- W4386745137 created "2023-09-15" @default.
- W4386745137 creator A5016150655 @default.
- W4386745137 creator A5026050445 @default.
- W4386745137 creator A5048753350 @default.
- W4386745137 creator A5061108079 @default.
- W4386745137 creator A5077465147 @default.
- W4386745137 creator A5087220842 @default.
- W4386745137 date "2023-09-14" @default.
- W4386745137 modified "2023-10-01" @default.
- W4386745137 title "Hybrid chitosan gold nanoparticles for photothermal therapy and enhanced cytotoxic action of 6-mercaptopurine on breast cancer cell line" @default.
- W4386745137 cites W2109689528 @default.
- W4386745137 cites W2127111217 @default.
- W4386745137 cites W2324080174 @default.
- W4386745137 cites W2494772945 @default.
- W4386745137 cites W2751032057 @default.
- W4386745137 cites W2997848944 @default.
- W4386745137 cites W3128167085 @default.
- W4386745137 cites W3137574599 @default.
- W4386745137 cites W3205480605 @default.
- W4386745137 cites W3205816259 @default.
- W4386745137 cites W4214847695 @default.
- W4386745137 cites W4220941976 @default.
- W4386745137 cites W4293171040 @default.
- W4386745137 cites W4294991338 @default.
- W4386745137 cites W4308643078 @default.
- W4386745137 cites W4309046303 @default.
- W4386745137 cites W4316095850 @default.
- W4386745137 cites W4318479988 @default.
- W4386745137 cites W4322769883 @default.
- W4386745137 cites W4375864743 @default.
- W4386745137 cites W4378909129 @default.
- W4386745137 cites W4381233697 @default.
- W4386745137 cites W4382941155 @default.
- W4386745137 cites W4385837298 @default.
- W4386745137 cites W4386254622 @default.
- W4386745137 doi "https://doi.org/10.1186/s43088-023-00419-z" @default.
- W4386745137 hasPublicationYear "2023" @default.
- W4386745137 type Work @default.
- W4386745137 citedByCount "0" @default.
- W4386745137 crossrefType "journal-article" @default.
- W4386745137 hasAuthorship W4386745137A5016150655 @default.
- W4386745137 hasAuthorship W4386745137A5026050445 @default.
- W4386745137 hasAuthorship W4386745137A5048753350 @default.
- W4386745137 hasAuthorship W4386745137A5061108079 @default.
- W4386745137 hasAuthorship W4386745137A5077465147 @default.
- W4386745137 hasAuthorship W4386745137A5087220842 @default.
- W4386745137 hasBestOaLocation W43867451371 @default.
- W4386745137 hasConcept C104819515 @default.
- W4386745137 hasConcept C109316439 @default.
- W4386745137 hasConcept C13965031 @default.
- W4386745137 hasConcept C155672457 @default.
- W4386745137 hasConcept C171250308 @default.
- W4386745137 hasConcept C178790620 @default.
- W4386745137 hasConcept C182606246 @default.
- W4386745137 hasConcept C185592680 @default.
- W4386745137 hasConcept C192562407 @default.
- W4386745137 hasConcept C202751555 @default.
- W4386745137 hasConcept C2779732960 @default.
- W4386745137 hasConcept C55493867 @default.
- W4386745137 hasConcept C86181022 @default.
- W4386745137 hasConceptScore W4386745137C104819515 @default.
- W4386745137 hasConceptScore W4386745137C109316439 @default.
- W4386745137 hasConceptScore W4386745137C13965031 @default.
- W4386745137 hasConceptScore W4386745137C155672457 @default.
- W4386745137 hasConceptScore W4386745137C171250308 @default.
- W4386745137 hasConceptScore W4386745137C178790620 @default.
- W4386745137 hasConceptScore W4386745137C182606246 @default.
- W4386745137 hasConceptScore W4386745137C185592680 @default.
- W4386745137 hasConceptScore W4386745137C192562407 @default.
- W4386745137 hasConceptScore W4386745137C202751555 @default.
- W4386745137 hasConceptScore W4386745137C2779732960 @default.
- W4386745137 hasConceptScore W4386745137C55493867 @default.
- W4386745137 hasConceptScore W4386745137C86181022 @default.
- W4386745137 hasIssue "1" @default.
- W4386745137 hasLocation W43867451371 @default.
- W4386745137 hasOpenAccess W4386745137 @default.
- W4386745137 hasPrimaryLocation W43867451371 @default.
- W4386745137 hasRelatedWork W1982563407 @default.
- W4386745137 hasRelatedWork W2015737156 @default.
- W4386745137 hasRelatedWork W2019378169 @default.
- W4386745137 hasRelatedWork W2024457833 @default.
- W4386745137 hasRelatedWork W2082811360 @default.
- W4386745137 hasRelatedWork W2140907237 @default.
- W4386745137 hasRelatedWork W2151625229 @default.
- W4386745137 hasRelatedWork W2167516940 @default.
- W4386745137 hasRelatedWork W2564879859 @default.
- W4386745137 hasRelatedWork W3042124153 @default.
- W4386745137 hasVolume "12" @default.
- W4386745137 isParatext "false" @default.
- W4386745137 isRetracted "false" @default.
- W4386745137 workType "article" @default.