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- W4386746775 endingPage "4552" @default.
- W4386746775 startingPage "4552" @default.
- W4386746775 abstract "The MET gene plays a vital role in cellular proliferation, earning it recognition as a principal oncogene. Therapies that target MET amplification have demonstrated promising results both in preclinical models and in specific clinical cases. A significant obstacle to these therapies is the ability to distinguish between focal amplification and polysomy, a task for which simple MET copy number measurement proves insufficient. To effectively differentiate between the two, it is crucial to utilize comparative measures, including in situ hybridization (ISH) with the centromere or next generation sequencing (NGS) with adjacent genes. Despite the promising potential of MET amplification treatment, the judicious selection of patients is paramount to maximize therapeutic efficacy. The effectiveness of MET inhibitors can fluctuate depending on the extent of MET amplification. Future research must seek to establish the ideal threshold value for MET amplification, identify the most efficacious combination therapies, and innovate new targeted treatments for patients exhibiting MET amplification." @default.
- W4386746775 created "2023-09-15" @default.
- W4386746775 creator A5018352586 @default.
- W4386746775 creator A5043209596 @default.
- W4386746775 creator A5082167694 @default.
- W4386746775 date "2023-09-14" @default.
- W4386746775 modified "2023-10-17" @default.
- W4386746775 title "Targeting MET Amplification: Opportunities and Obstacles in Therapeutic Approaches" @default.
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