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• W4386752743 abstract "The PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell differentiation, tissue homeostasis, and organogenesis and regeneration, caspase-2, RAIDD and PIDD1 engagement in neuronal development was shown. Here, we focus on the involvement of PIDDosome components in neurodegenerative disorders, including retinal neuropathies, different types of brain damage, and Alzheimer's disease (AD), Huntington's disease (HD), and Lewy body disease. We also discuss pathogenic variants of PIDD1, RAIDD, and caspase-2 that are associated with intellectual, behavioral, and psychological abnormalities, together with prospective PIDDosome inhibition strategies and their potential clinical application." @default.
• W4386752743 created "2023-09-15" @default.
• W4386752743 creator A5013939452 @default.
• W4386752743 creator A5017471867 @default.
• W4386752743 creator A5080920861 @default.
• W4386752743 creator A5089390726 @default.
• W4386752743 date "2023-09-01" @default.
• W4386752743 modified "2023-10-02" @default.
• W4386752743 title "Total recall: the role of PIDDosome components in neurodegeneration" @default.
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