FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386753381> ?p ?o ?g. }

• W4386753381 endingPage "115478" @default.
• W4386753381 startingPage "115478" @default.
• W4386753381 abstract "Aflatoxin B1 (AFB1) is considered the most toxic carcinogenic compound, and exposure to AFB1 is highly associated with hepatocellular carcinoma. The aim of this study was to investigate the effects of different doses of AFB1 on growth performance and the liver of rabbits, as well as explore its underlying mechanisms. A total of eighty 30-day-old meat rabbits were randomly divided into four treatments. The control group was fed a pollution-free diet, while the AFL, AFM, and AFH groups were fed contaminated diets containing 13 μg/kg, 19 μg/kg, and 25 μg/kg of AFB1, respectively. The results showed that AFB1 had detrimental effects on the production performance of rabbits, resulting in decreased weight gain. Additionally, AFB1 exposure was associated with increased activity of Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT), as well as decreased levels of total protein (TP) and albumin (ALB) in the serum. AFB1 induced the production of reactive oxygen species (ROS) and malondialdehyde (MDA) while inhibiting the activity of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activity in liver tissues. AFB1 decreased the mRNA transcription and protein expression of nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H dehydrogenase quinone-1 (NQO-1). AFB1 not only decreased the contents of cytochrome P4501A2 (CYP1A2), cytochrome P4502A6 (CYP2A6) and cytochrome P4503A4 (CYP3A4) but also increased the content of AFB1-DNA adducts in the liver. Furthermore, AFB1 enhanced the expression of cytochrome c (cyt-c), caspase-9, caspase-3, and Bcl-2-associated X protein (Bax), while inhibiting the expression of B-cell lymphoma 2 (Bcl-2). Therefore, we demonstrated that AFB1 triggered apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway, and decreased rabbit performance." @default.
• W4386753381 created "2023-09-15" @default.
• W4386753381 creator A5025930783 @default.
• W4386753381 creator A5031115326 @default.
• W4386753381 creator A5035991452 @default.
• W4386753381 creator A5041574138 @default.
• W4386753381 creator A5044757881 @default.
• W4386753381 creator A5049552415 @default.
• W4386753381 creator A5060002817 @default.
• W4386753381 creator A5082406903 @default.
• W4386753381 date "2023-10-01" @default.
• W4386753381 modified "2023-09-30" @default.
• W4386753381 title "Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway" @default.
• W4386753381 cites W1560222544 @default.
• W4386753381 cites W160658944 @default.
• W4386753381 cites W2013803253 @default.
• W4386753381 cites W2027779353 @default.
• W4386753381 cites W2076759068 @default.
• W4386753381 cites W2108205677 @default.
• W4386753381 cites W2142660538 @default.
• W4386753381 cites W2272916692 @default.
• W4386753381 cites W2572570387 @default.
• W4386753381 cites W2597046008 @default.
• W4386753381 cites W2618334751 @default.
• W4386753381 cites W2685846213 @default.
• W4386753381 cites W2794139372 @default.
• W4386753381 cites W2804189517 @default.
• W4386753381 cites W2891738102 @default.
• W4386753381 cites W2906965285 @default.
• W4386753381 cites W2912292715 @default.
• W4386753381 cites W2966068859 @default.
• W4386753381 cites W3000815635 @default.
• W4386753381 cites W3138918993 @default.
• W4386753381 cites W3141533581 @default.
• W4386753381 cites W3158687056 @default.
• W4386753381 cites W3201714647 @default.
• W4386753381 cites W3207532313 @default.
• W4386753381 cites W4200461344 @default.
• W4386753381 cites W4205367330 @default.
• W4386753381 cites W4210450130 @default.
• W4386753381 cites W4280612769 @default.
• W4386753381 cites W4281613783 @default.
• W4386753381 cites W4283586162 @default.
• W4386753381 cites W4286229670 @default.
• W4386753381 cites W4290999121 @default.
• W4386753381 cites W4313346417 @default.
• W4386753381 doi "https://doi.org/10.1016/j.ecoenv.2023.115478" @default.
• W4386753381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37716070" @default.
• W4386753381 hasPublicationYear "2023" @default.
• W4386753381 type Work @default.
• W4386753381 citedByCount "0" @default.
• W4386753381 crossrefType "journal-article" @default.
• W4386753381 hasAuthorship W4386753381A5025930783 @default.
• W4386753381 hasAuthorship W4386753381A5031115326 @default.
• W4386753381 hasAuthorship W4386753381A5035991452 @default.
• W4386753381 hasAuthorship W4386753381A5041574138 @default.
• W4386753381 hasAuthorship W4386753381A5044757881 @default.
• W4386753381 hasAuthorship W4386753381A5049552415 @default.
• W4386753381 hasAuthorship W4386753381A5060002817 @default.
• W4386753381 hasAuthorship W4386753381A5082406903 @default.
• W4386753381 hasBestOaLocation W43867533811 @default.
• W4386753381 hasConcept C114246631 @default.
• W4386753381 hasConcept C153911025 @default.
• W4386753381 hasConcept C181199279 @default.
• W4386753381 hasConcept C185592680 @default.
• W4386753381 hasConcept C190283241 @default.
• W4386753381 hasConcept C2775838275 @default.
• W4386753381 hasConcept C2776151105 @default.
• W4386753381 hasConcept C2778401633 @default.
• W4386753381 hasConcept C2778979269 @default.
• W4386753381 hasConcept C29311851 @default.
• W4386753381 hasConcept C31903555 @default.
• W4386753381 hasConcept C40758303 @default.
• W4386753381 hasConcept C48349386 @default.
• W4386753381 hasConcept C526171541 @default.
• W4386753381 hasConcept C538909803 @default.
• W4386753381 hasConcept C55493867 @default.
• W4386753381 hasConcept C86745063 @default.
• W4386753381 hasConcept C86803240 @default.
• W4386753381 hasConceptScore W4386753381C114246631 @default.
• W4386753381 hasConceptScore W4386753381C153911025 @default.
• W4386753381 hasConceptScore W4386753381C181199279 @default.
• W4386753381 hasConceptScore W4386753381C185592680 @default.
• W4386753381 hasConceptScore W4386753381C190283241 @default.
• W4386753381 hasConceptScore W4386753381C2775838275 @default.
• W4386753381 hasConceptScore W4386753381C2776151105 @default.
• W4386753381 hasConceptScore W4386753381C2778401633 @default.
• W4386753381 hasConceptScore W4386753381C2778979269 @default.
• W4386753381 hasConceptScore W4386753381C29311851 @default.
• W4386753381 hasConceptScore W4386753381C31903555 @default.
• W4386753381 hasConceptScore W4386753381C40758303 @default.
• W4386753381 hasConceptScore W4386753381C48349386 @default.
• W4386753381 hasConceptScore W4386753381C526171541 @default.
• W4386753381 hasConceptScore W4386753381C538909803 @default.
• W4386753381 hasConceptScore W4386753381C55493867 @default.
• W4386753381 hasConceptScore W4386753381C86745063 @default.
• W4386753381 hasConceptScore W4386753381C86803240 @default.
• W4386753381 hasLocation W43867533811 @default.

• next