FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386756960> ?p ?o ?g. }

• W4386756960 abstract "Abstract Candida auris is an emerging, multidrug‐resistant yeast, causing outbreaks in healthcare facilities. Echinocandins are the antifungal drugs of choice to treat candidiasis, as they cause few side effects and resistance is rarely found. Previously, immunocompromised patients from Kuwait with C . auris colonisation or infection were treated with echinocandins, and within days to months, resistance was reported in urine isolates. To determine whether the development of echinocandin resistance was due to independent introductions of resistant strains or resulted from intra‐patient resistance development, whole genome sequencing (WGS) single‐nucleotide polymorphism (SNP) analysis was performed on susceptible ( n = 26) and echinocandin‐resistant ( n = 6) isolates from seven patients. WGS SNP analysis identified three distinct clusters differing 17–127 SNPs from two patients, and the remaining isolates from five patients, respectively. Sequential isolates within patients had a maximum of 11 SNP differences over a time period of 1–10 months. The majority of isolates with reduced susceptibility displayed unique FKS1 substitutions including a novel FKS1 M690V substitution, and nearly all were genetically related, ranging from only three to six SNP differences compared to susceptible isolates from the same patient. Resistant isolates from three patients shared the common FKS1 S639F substitution; however, WGS analysis did not suggest a common source. These findings strongly indicate that echinocandin resistance is induced during antifungal treatment. Future studies should determine whether such echinocandin‐resistant strains are capable of long‐term colonisation, cause subsequent breakthrough candidiasis, have a propensity to cross‐infect other patients, or remain viable for longer time periods in the hospital environment." @default.
• W4386756960 created "2023-09-16" @default.
• W4386756960 creator A5009642231 @default.
• W4386756960 creator A5011080111 @default.
• W4386756960 creator A5013702613 @default.
• W4386756960 creator A5026375650 @default.
• W4386756960 creator A5043186278 @default.
• W4386756960 creator A5044995420 @default.
• W4386756960 creator A5050560666 @default.
• W4386756960 creator A5086415980 @default.
• W4386756960 creator A5091505180 @default.
• W4386756960 date "2023-09-15" @default.
• W4386756960 modified "2023-09-26" @default.
• W4386756960 title "Whole genome sequencing analysis demonstrates therapy‐induced echinocandin resistance in <i>Candida auris</i> isolates" @default.
• W4386756960 cites W1583479269 @default.
• W4386756960 cites W1987629821 @default.
• W4386756960 cites W2099951777 @default.
• W4386756960 cites W2167155938 @default.
• W4386756960 cites W2612911162 @default.
• W4386756960 cites W2784269063 @default.
• W4386756960 cites W2790220629 @default.
• W4386756960 cites W2890220120 @default.
• W4386756960 cites W2894594494 @default.
• W4386756960 cites W2896428191 @default.
• W4386756960 cites W2927337314 @default.
• W4386756960 cites W2947844837 @default.
• W4386756960 cites W2981008414 @default.
• W4386756960 cites W3107977263 @default.
• W4386756960 cites W3123093675 @default.
• W4386756960 cites W3137198821 @default.
• W4386756960 cites W3145703097 @default.
• W4386756960 cites W3156847645 @default.
• W4386756960 cites W3180239426 @default.
• W4386756960 cites W3208107712 @default.
• W4386756960 cites W4200483743 @default.
• W4386756960 cites W4220806635 @default.
• W4386756960 cites W4221094564 @default.
• W4386756960 cites W4247053599 @default.
• W4386756960 cites W4251751280 @default.
• W4386756960 cites W4280499270 @default.
• W4386756960 cites W4283817659 @default.
• W4386756960 cites W4294176771 @default.
• W4386756960 cites W4297229549 @default.
• W4386756960 cites W4300484810 @default.
• W4386756960 cites W4304777637 @default.
• W4386756960 cites W4307133975 @default.
• W4386756960 cites W4320896711 @default.
• W4386756960 cites W4324311089 @default.
• W4386756960 cites W4362657231 @default.
• W4386756960 cites W4367624043 @default.
• W4386756960 cites W4377861245 @default.
• W4386756960 cites W4377938987 @default.
• W4386756960 cites W4383058312 @default.
• W4386756960 cites W4383215700 @default.
• W4386756960 doi "https://doi.org/10.1111/myc.13655" @default.
• W4386756960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37712885" @default.
• W4386756960 hasPublicationYear "2023" @default.
• W4386756960 type Work @default.
• W4386756960 citedByCount "0" @default.
• W4386756960 crossrefType "journal-article" @default.
• W4386756960 hasAuthorship W4386756960A5009642231 @default.
• W4386756960 hasAuthorship W4386756960A5011080111 @default.
• W4386756960 hasAuthorship W4386756960A5013702613 @default.
• W4386756960 hasAuthorship W4386756960A5026375650 @default.
• W4386756960 hasAuthorship W4386756960A5043186278 @default.
• W4386756960 hasAuthorship W4386756960A5044995420 @default.
• W4386756960 hasAuthorship W4386756960A5050560666 @default.
• W4386756960 hasAuthorship W4386756960A5086415980 @default.
• W4386756960 hasAuthorship W4386756960A5091505180 @default.
• W4386756960 hasBestOaLocation W43867569601 @default.
• W4386756960 hasConcept C114851261 @default.
• W4386756960 hasConcept C2779320740 @default.
• W4386756960 hasConcept C2779548794 @default.
• W4386756960 hasConcept C2780651595 @default.
• W4386756960 hasConcept C2909786013 @default.
• W4386756960 hasConcept C86803240 @default.
• W4386756960 hasConcept C89423630 @default.
• W4386756960 hasConceptScore W4386756960C114851261 @default.
• W4386756960 hasConceptScore W4386756960C2779320740 @default.
• W4386756960 hasConceptScore W4386756960C2779548794 @default.
• W4386756960 hasConceptScore W4386756960C2780651595 @default.
• W4386756960 hasConceptScore W4386756960C2909786013 @default.
• W4386756960 hasConceptScore W4386756960C86803240 @default.
• W4386756960 hasConceptScore W4386756960C89423630 @default.
• W4386756960 hasLocation W43867569601 @default.
• W4386756960 hasLocation W43867569602 @default.
• W4386756960 hasOpenAccess W4386756960 @default.
• W4386756960 hasPrimaryLocation W43867569601 @default.
• W4386756960 hasRelatedWork W2739674022 @default.
• W4386756960 hasRelatedWork W2750959598 @default.
• W4386756960 hasRelatedWork W2767781708 @default.
• W4386756960 hasRelatedWork W2898724298 @default.
• W4386756960 hasRelatedWork W2979571929 @default.
• W4386756960 hasRelatedWork W3112806667 @default.
• W4386756960 hasRelatedWork W4324311089 @default.
• W4386756960 hasRelatedWork W4361190559 @default.
• W4386756960 hasRelatedWork W4362577949 @default.
• W4386756960 hasRelatedWork W4377938987 @default.
• W4386756960 isParatext "false" @default.
• W4386756960 isRetracted "false" @default.

• next