FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386756988> ?p ?o ?g. }

• W4386756988 endingPage "9" @default.
• W4386756988 startingPage "1" @default.
• W4386756988 abstract "<b><i>Introduction:</i></b> In FIDELIO-DKD, finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease and type 2 diabetes (T2D). This post hoc analysis explores finerenone in patients from the Asian region. <b><i>Methods:</i></b> In FIDELIO-DKD, 5,674 patients with T2D and urine albumin-to-creatinine ratio (UACR) ≥30–&lt;300 mg/g and estimated glomerular filtration rate (eGFR) ≥25–&lt;60 mL/min/1.73 m² or UACR ≥300–≤5,000 mg/g and eGFR ≥25–&lt;75 mL/min/1.73 m², treated with optimized renin-angiotensin system blockade, were randomized 1:1 to finerenone or placebo. Efficacy outcomes included a primary kidney composite (time to kidney failure, sustained decrease of ≥40% in eGFR from baseline, and death from renal causes) and secondary cardiovascular (CV) (time to CV death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for heart failure) and kidney (time to kidney failure, sustained decrease of ≥57% in eGFR from baseline, and death from renal causes) composites. <b><i>Results:</i></b> Of 1,327 patients in the Asian subgroup, 665 received finerenone. Finerenone reduced the ≥40% and ≥57% eGFR kidney and CV composite outcomes versus placebo in the Asian subgroup (hazard ratio [HR]: 0.70; 95% confidence interval [CI]: 0.56–0.87, HR: 0.73; 95% CI: 0.55–0.97, and HR: 0.85; 95% CI: 0.59–1.21, respectively), with no apparent differences versus patients from the rest of the world (HR: 0.88; 95% CI: 0.77–1.02; <i>p</i> interaction 0.09, HR: 0.78; 95% CI: 0.64–0.95; <i>p</i> interaction 0.71, and HR: 0.86; 95% CI: 0.74–1.00; <i>p</i> interaction 0.95, respectively). The safety profile of finerenone was similar across subgroups. <b><i>Conclusion:</i></b> Finerenone produces similar cardiorenal benefits in Asian and non-Asian patients." @default.
• W4386756988 created "2023-09-16" @default.
• W4386756988 creator A5007204226 @default.
• W4386756988 creator A5028519674 @default.
• W4386756988 creator A5040062593 @default.
• W4386756988 creator A5041442093 @default.
• W4386756988 creator A5042843111 @default.
• W4386756988 creator A5050612283 @default.
• W4386756988 creator A5053080119 @default.
• W4386756988 creator A5054496507 @default.
• W4386756988 creator A5057252015 @default.
• W4386756988 creator A5068889350 @default.
• W4386756988 creator A5069516269 @default.
• W4386756988 creator A5074496684 @default.
• W4386756988 creator A5087729511 @default.
• W4386756988 date "2023-09-14" @default.
• W4386756988 modified "2023-10-12" @default.
• W4386756988 title "Cardiorenal Outcomes with Finerenone in Asian Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELIO-DKD post hoc Analysis" @default.
• W4386756988 cites W2045045479 @default.
• W4386756988 cites W2045181376 @default.
• W4386756988 cites W2056976690 @default.
• W4386756988 cites W2078479010 @default.
• W4386756988 cites W2080751713 @default.
• W4386756988 cites W2135488617 @default.
• W4386756988 cites W2138612646 @default.
• W4386756988 cites W2530714323 @default.
• W4386756988 cites W2791921452 @default.
• W4386756988 cites W2835775342 @default.
• W4386756988 cites W2939222610 @default.
• W4386756988 cites W2982024515 @default.
• W4386756988 cites W3088173406 @default.
• W4386756988 cites W3093851112 @default.
• W4386756988 cites W3094429645 @default.
• W4386756988 cites W3095570107 @default.
• W4386756988 cites W3188543560 @default.
• W4386756988 doi "https://doi.org/10.1159/000532102" @default.
• W4386756988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37708857" @default.
• W4386756988 hasPublicationYear "2023" @default.
• W4386756988 type Work @default.
• W4386756988 citedByCount "0" @default.
• W4386756988 crossrefType "journal-article" @default.
• W4386756988 hasAuthorship W4386756988A5007204226 @default.
• W4386756988 hasAuthorship W4386756988A5028519674 @default.
• W4386756988 hasAuthorship W4386756988A5040062593 @default.
• W4386756988 hasAuthorship W4386756988A5041442093 @default.
• W4386756988 hasAuthorship W4386756988A5042843111 @default.
• W4386756988 hasAuthorship W4386756988A5050612283 @default.
• W4386756988 hasAuthorship W4386756988A5053080119 @default.
• W4386756988 hasAuthorship W4386756988A5054496507 @default.
• W4386756988 hasAuthorship W4386756988A5057252015 @default.
• W4386756988 hasAuthorship W4386756988A5068889350 @default.
• W4386756988 hasAuthorship W4386756988A5069516269 @default.
• W4386756988 hasAuthorship W4386756988A5074496684 @default.
• W4386756988 hasAuthorship W4386756988A5087729511 @default.
• W4386756988 hasBestOaLocation W43867569881 @default.
• W4386756988 hasConcept C126322002 @default.
• W4386756988 hasConcept C126894567 @default.
• W4386756988 hasConcept C134018914 @default.
• W4386756988 hasConcept C159641895 @default.
• W4386756988 hasConcept C187960798 @default.
• W4386756988 hasConcept C207103383 @default.
• W4386756988 hasConcept C2777180221 @default.
• W4386756988 hasConcept C2778198053 @default.
• W4386756988 hasConcept C2778653478 @default.
• W4386756988 hasConcept C2780306776 @default.
• W4386756988 hasConcept C44249647 @default.
• W4386756988 hasConcept C555293320 @default.
• W4386756988 hasConcept C67761136 @default.
• W4386756988 hasConcept C71924100 @default.
• W4386756988 hasConcept C90924648 @default.
• W4386756988 hasConceptScore W4386756988C126322002 @default.
• W4386756988 hasConceptScore W4386756988C126894567 @default.
• W4386756988 hasConceptScore W4386756988C134018914 @default.
• W4386756988 hasConceptScore W4386756988C159641895 @default.
• W4386756988 hasConceptScore W4386756988C187960798 @default.
• W4386756988 hasConceptScore W4386756988C207103383 @default.
• W4386756988 hasConceptScore W4386756988C2777180221 @default.
• W4386756988 hasConceptScore W4386756988C2778198053 @default.
• W4386756988 hasConceptScore W4386756988C2778653478 @default.
• W4386756988 hasConceptScore W4386756988C2780306776 @default.
• W4386756988 hasConceptScore W4386756988C44249647 @default.
• W4386756988 hasConceptScore W4386756988C555293320 @default.
• W4386756988 hasConceptScore W4386756988C67761136 @default.
• W4386756988 hasConceptScore W4386756988C71924100 @default.
• W4386756988 hasConceptScore W4386756988C90924648 @default.
• W4386756988 hasLocation W43867569881 @default.
• W4386756988 hasLocation W43867569882 @default.
• W4386756988 hasOpenAccess W4386756988 @default.
• W4386756988 hasPrimaryLocation W43867569881 @default.
• W4386756988 hasRelatedWork W1564222293 @default.
• W4386756988 hasRelatedWork W1948603161 @default.
• W4386756988 hasRelatedWork W2022369832 @default.
• W4386756988 hasRelatedWork W2050789305 @default.
• W4386756988 hasRelatedWork W2313598751 @default.
• W4386756988 hasRelatedWork W2387860588 @default.
• W4386756988 hasRelatedWork W2411849704 @default.
• W4386756988 hasRelatedWork W2909812024 @default.
• W4386756988 hasRelatedWork W393698729 @default.

• next