FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386757545> ?p ?o ?g. }

• W4386757545 endingPage "804" @default.
• W4386757545 startingPage "796" @default.
• W4386757545 abstract "Data from the International PNH Registry (NCT01374360) were used to estimate the overall survival and first occurrence of thromboembolic events/major adverse vascular events (TEs/MAVEs) for eculizumab-treated patients with paroxysmal nocturnal hemoglobinuria (PNH) compared with a contemporaneous untreated cohort.Patients enrolled in the Registry from March 16, 2007, to February 14, 2022, were included. Treated patients received eculizumab for >35 days; untreated patients did not receive eculizumab at any time. Univariable and multivariable analyses were performed using a Cox proportional hazards regression model comparing eculizumab treatment periods to untreated periods and were adjusted for baseline covariates (e.g., high disease activity [HDA], transfusion dependency, and eculizumab treatment status).The analysis included 4118 patients. The univariable hazard ratio (HR) (95% CI) for mortality in eculizumab-treated time versus untreated time was 0.51 (0.41-0.64; p < 0.0001). Significant baseline covariates included age, sex, history of bone marrow failure, ≥4 erythrocyte transfusions within 12 months before baseline, and an estimated glomerular filtration rate ≤ 60 mL/min/1.73 m2 (all p < 0.0001). In the adjusted analysis, patients with baseline HDA had the greatest reduction in mortality risk (HR [95% CI], 0.51 [0.36-0.72]). Treated patients had approximately 60% reduction in TE/MAVE risk during treated versus untreated time (HR [95% CI]: TE: 0.40 [0.26-0.62], MAVE: 0.37 [0.26-0.54]; p < 0.0001).Using data from the largest Registry of patients with PNH, with ≥14 years of overall follow-up, we demonstrate that treatment with eculizumab conferred a 49% relative benefit in survival and an approximately 60% reduction in TE/MAVE risk." @default.
• W4386757545 created "2023-09-16" @default.
• W4386757545 creator A5009473954 @default.
• W4386757545 creator A5014697224 @default.
• W4386757545 creator A5031046212 @default.
• W4386757545 creator A5031643718 @default.
• W4386757545 creator A5048889590 @default.
• W4386757545 creator A5051544503 @default.
• W4386757545 creator A5055099180 @default.
• W4386757545 creator A5055188307 @default.
• W4386757545 creator A5085429434 @default.
• W4386757545 creator A5089636175 @default.
• W4386757545 date "2023-09-15" @default.
• W4386757545 modified "2023-10-18" @default.
• W4386757545 title "Long‐term effectiveness of eculizumab: Data from the International <scp>PNH</scp> Registry" @default.
• W4386757545 cites W1978700432 @default.
• W4386757545 cites W1985084429 @default.
• W4386757545 cites W1990431733 @default.
• W4386757545 cites W1998319221 @default.
• W4386757545 cites W2058082996 @default.
• W4386757545 cites W2074202650 @default.
• W4386757545 cites W2121920823 @default.
• W4386757545 cites W2134914390 @default.
• W4386757545 cites W2150027863 @default.
• W4386757545 cites W2151709211 @default.
• W4386757545 cites W2163541746 @default.
• W4386757545 cites W2171068466 @default.
• W4386757545 cites W2209557348 @default.
• W4386757545 cites W2267134012 @default.
• W4386757545 cites W2340165058 @default.
• W4386757545 cites W2559144607 @default.
• W4386757545 cites W2616618502 @default.
• W4386757545 cites W3022268070 @default.
• W4386757545 cites W3081877862 @default.
• W4386757545 cites W4224268105 @default.
• W4386757545 cites W4225777161 @default.
• W4386757545 doi "https://doi.org/10.1111/ejh.14080" @default.
• W4386757545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37712908" @default.
• W4386757545 hasPublicationYear "2023" @default.
• W4386757545 type Work @default.
• W4386757545 citedByCount "0" @default.
• W4386757545 crossrefType "journal-article" @default.
• W4386757545 hasAuthorship W4386757545A5009473954 @default.
• W4386757545 hasAuthorship W4386757545A5014697224 @default.
• W4386757545 hasAuthorship W4386757545A5031046212 @default.
• W4386757545 hasAuthorship W4386757545A5031643718 @default.
• W4386757545 hasAuthorship W4386757545A5048889590 @default.
• W4386757545 hasAuthorship W4386757545A5051544503 @default.
• W4386757545 hasAuthorship W4386757545A5055099180 @default.
• W4386757545 hasAuthorship W4386757545A5055188307 @default.
• W4386757545 hasAuthorship W4386757545A5085429434 @default.
• W4386757545 hasAuthorship W4386757545A5089636175 @default.
• W4386757545 hasBestOaLocation W43867575451 @default.
• W4386757545 hasConcept C111684460 @default.
• W4386757545 hasConcept C126322002 @default.
• W4386757545 hasConcept C141071460 @default.
• W4386757545 hasConcept C159641895 @default.
• W4386757545 hasConcept C159654299 @default.
• W4386757545 hasConcept C203014093 @default.
• W4386757545 hasConcept C207103383 @default.
• W4386757545 hasConcept C2777346216 @default.
• W4386757545 hasConcept C2777991916 @default.
• W4386757545 hasConcept C2778248108 @default.
• W4386757545 hasConcept C2778639011 @default.
• W4386757545 hasConcept C44249647 @default.
• W4386757545 hasConcept C50382708 @default.
• W4386757545 hasConcept C71924100 @default.
• W4386757545 hasConcept C72563966 @default.
• W4386757545 hasConcept C90924648 @default.
• W4386757545 hasConceptScore W4386757545C111684460 @default.
• W4386757545 hasConceptScore W4386757545C126322002 @default.
• W4386757545 hasConceptScore W4386757545C141071460 @default.
• W4386757545 hasConceptScore W4386757545C159641895 @default.
• W4386757545 hasConceptScore W4386757545C159654299 @default.
• W4386757545 hasConceptScore W4386757545C203014093 @default.
• W4386757545 hasConceptScore W4386757545C207103383 @default.
• W4386757545 hasConceptScore W4386757545C2777346216 @default.
• W4386757545 hasConceptScore W4386757545C2777991916 @default.
• W4386757545 hasConceptScore W4386757545C2778248108 @default.
• W4386757545 hasConceptScore W4386757545C2778639011 @default.
• W4386757545 hasConceptScore W4386757545C44249647 @default.
• W4386757545 hasConceptScore W4386757545C50382708 @default.
• W4386757545 hasConceptScore W4386757545C71924100 @default.
• W4386757545 hasConceptScore W4386757545C72563966 @default.
• W4386757545 hasConceptScore W4386757545C90924648 @default.
• W4386757545 hasFunder F4320309052 @default.
• W4386757545 hasIssue "5" @default.
• W4386757545 hasLocation W43867575451 @default.
• W4386757545 hasLocation W43867575452 @default.
• W4386757545 hasOpenAccess W4386757545 @default.
• W4386757545 hasPrimaryLocation W43867575451 @default.
• W4386757545 hasRelatedWork W1600863849 @default.
• W4386757545 hasRelatedWork W2044079477 @default.
• W4386757545 hasRelatedWork W2093098007 @default.
• W4386757545 hasRelatedWork W2098778053 @default.
• W4386757545 hasRelatedWork W2100352422 @default.
• W4386757545 hasRelatedWork W2149245783 @default.
• W4386757545 hasRelatedWork W2330809941 @default.

• next