Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386757611> ?p ?o ?g. }
- W4386757611 abstract "Abstract Depression, a devastating brain illness, necessitates the exploration of novel antidepressant treatments. We evaluated the antidepressant effects of free curcumin, zinc oxide nanoparticles (ZnO NPs), and curcumin-conjugated zinc oxide nanoparticles (Zn(cur)O NPs). The nanoformulations were extensively characterized using advanced techniques. An acute toxicity study ensured the safety of Zn(cur)O NPs. Rats were assigned to one of five groups: control, reserpine-induced depression model, treatment with ZnO NPs, free curcumin, or Zn(cur)O NPs. Behavioral assessments (forced swimming test [FST] and open-field test [OFT]) and neurochemical analyses were conducted. Zn(cur)O NPs exhibited superior efficacy in ameliorating reserpine-induced behavioral and neurochemical effects compared to free curcumin and ZnO NPs. The reserpine-induced model displayed reduced motor activity, swimming time, and increased immobility time in the FST and OFT. Treatment with Zn(cur)O NPs 45 mg/kg significantly improved motor activity and reduced immobility time. Furthermore, Zn(cur)O NPs decreased malondialdehyde (MDA) levels while increasing reduced glutathione (GSH) and catalase (CAT) levels. Additionally, concentrations of serotonin (5-HT) and norepinephrine (NE) increased. In conclusion, curcumin-conjugated zinc oxide nanoparticles demonstrate potent antidepressant effects, alleviating depressive-like behavior in rats. These findings support Zn(cur)O NPs as a promising therapeutic strategy for depression management, warranting further investigation and clinical validation." @default.
- W4386757611 created "2023-09-16" @default.
- W4386757611 creator A5001295257 @default.
- W4386757611 creator A5027814734 @default.
- W4386757611 creator A5067316942 @default.
- W4386757611 creator A5090542345 @default.
- W4386757611 creator A5090816211 @default.
- W4386757611 creator A5092456930 @default.
- W4386757611 date "2023-09-15" @default.
- W4386757611 modified "2023-09-27" @default.
- W4386757611 title "Evaluation of the Therapeutic Effect of Curcumin-Conjugated Zinc Oxide Nanoparticles on Reserpine-Induced Depression in Wistar Rats" @default.
- W4386757611 cites W157666778 @default.
- W4386757611 cites W191793640 @default.
- W4386757611 cites W1920770718 @default.
- W4386757611 cites W1963862229 @default.
- W4386757611 cites W1965739950 @default.
- W4386757611 cites W1972869003 @default.
- W4386757611 cites W1974726214 @default.
- W4386757611 cites W1976863855 @default.
- W4386757611 cites W1980474344 @default.
- W4386757611 cites W1981963123 @default.
- W4386757611 cites W1987890594 @default.
- W4386757611 cites W1991197498 @default.
- W4386757611 cites W1992795501 @default.
- W4386757611 cites W1996697333 @default.
- W4386757611 cites W1997906526 @default.
- W4386757611 cites W1998596192 @default.
- W4386757611 cites W2003982930 @default.
- W4386757611 cites W2009176936 @default.
- W4386757611 cites W2016056242 @default.
- W4386757611 cites W2033431239 @default.
- W4386757611 cites W2037761163 @default.
- W4386757611 cites W2038205497 @default.
- W4386757611 cites W2044269687 @default.
- W4386757611 cites W2045549932 @default.
- W4386757611 cites W2045632847 @default.
- W4386757611 cites W2048175288 @default.
- W4386757611 cites W2055457894 @default.
- W4386757611 cites W2059110340 @default.
- W4386757611 cites W2060455759 @default.
- W4386757611 cites W2064965507 @default.
- W4386757611 cites W2076772239 @default.
- W4386757611 cites W2081363371 @default.
- W4386757611 cites W2083351038 @default.
- W4386757611 cites W2086702415 @default.
- W4386757611 cites W2097745840 @default.
- W4386757611 cites W2101253204 @default.
- W4386757611 cites W2102192655 @default.
- W4386757611 cites W2109022596 @default.
- W4386757611 cites W2110652761 @default.
- W4386757611 cites W2116833838 @default.
- W4386757611 cites W2125521135 @default.
- W4386757611 cites W2129579709 @default.
- W4386757611 cites W2140720810 @default.
- W4386757611 cites W2149155163 @default.
- W4386757611 cites W2156767606 @default.
- W4386757611 cites W2157219711 @default.
- W4386757611 cites W2162861984 @default.
- W4386757611 cites W2164073227 @default.
- W4386757611 cites W2201607793 @default.
- W4386757611 cites W2308652597 @default.
- W4386757611 cites W2318388129 @default.
- W4386757611 cites W2341640002 @default.
- W4386757611 cites W2411013142 @default.
- W4386757611 cites W2514190534 @default.
- W4386757611 cites W2582581373 @default.
- W4386757611 cites W2589563852 @default.
- W4386757611 cites W2596398126 @default.
- W4386757611 cites W2800241864 @default.
- W4386757611 cites W2903093081 @default.
- W4386757611 cites W2909714309 @default.
- W4386757611 cites W2910058584 @default.
- W4386757611 cites W2954601548 @default.
- W4386757611 cites W2975822783 @default.
- W4386757611 cites W3003504320 @default.
- W4386757611 cites W3041520730 @default.
- W4386757611 cites W3041798915 @default.
- W4386757611 cites W3086552567 @default.
- W4386757611 cites W3135086645 @default.
- W4386757611 cites W4214833370 @default.
- W4386757611 cites W4250109156 @default.
- W4386757611 cites W4251472959 @default.
- W4386757611 cites W4377695743 @default.
- W4386757611 cites W84932982 @default.
- W4386757611 doi "https://doi.org/10.1007/s12011-023-03849-z" @default.
- W4386757611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37713054" @default.
- W4386757611 hasPublicationYear "2023" @default.
- W4386757611 type Work @default.
- W4386757611 citedByCount "0" @default.
- W4386757611 crossrefType "journal-article" @default.
- W4386757611 hasAuthorship W4386757611A5001295257 @default.
- W4386757611 hasAuthorship W4386757611A5027814734 @default.
- W4386757611 hasAuthorship W4386757611A5067316942 @default.
- W4386757611 hasAuthorship W4386757611A5090542345 @default.
- W4386757611 hasAuthorship W4386757611A5090816211 @default.
- W4386757611 hasAuthorship W4386757611A5092456930 @default.
- W4386757611 hasBestOaLocation W43867576111 @default.
- W4386757611 hasConcept C126322002 @default.
- W4386757611 hasConcept C136569192 @default.
- W4386757611 hasConcept C178790620 @default.