Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386757931> ?p ?o ?g. }
- W4386757931 abstract "Abstract Clinically symptomatic type 1 diabetes (stage 3 type 1 diabetes) is preceded by a pre-symptomatic phase, characterised by progressive loss of functional beta cell mass after the onset of islet autoimmunity, with (stage 2) or without (stage 1) measurable changes in glucose profile during an OGTT. Identifying metabolic tests that can longitudinally track changes in beta cell function is of pivotal importance to track disease progression and measure the effect of disease-modifying interventions. In this review we describe the metabolic changes that occur in the early pre-symptomatic stages of type 1 diabetes with respect to both insulin secretion and insulin sensitivity, as well as the measurable outcomes that can be derived from the available tests. We also discuss the use of metabolic modelling to identify insulin secretion and sensitivity, and the measurable changes during dynamic tests such as the OGTT. Finally, we review the role of risk indices and minimally invasive measures such as those derived from the use of continuous glucose monitoring. Graphical Abstract" @default.
- W4386757931 created "2023-09-16" @default.
- W4386757931 creator A5015518286 @default.
- W4386757931 creator A5017332392 @default.
- W4386757931 creator A5024022404 @default.
- W4386757931 creator A5071649962 @default.
- W4386757931 creator A5076842743 @default.
- W4386757931 creator A5078314492 @default.
- W4386757931 date "2023-09-15" @default.
- W4386757931 modified "2023-09-26" @default.
- W4386757931 title "Quantifying beta cell function in the preclinical stages of type 1 diabetes" @default.
- W4386757931 cites W1499340174 @default.
- W4386757931 cites W1925140590 @default.
- W4386757931 cites W1942296996 @default.
- W4386757931 cites W1964403842 @default.
- W4386757931 cites W1969759774 @default.
- W4386757931 cites W1974313427 @default.
- W4386757931 cites W1979180498 @default.
- W4386757931 cites W1979768668 @default.
- W4386757931 cites W1981581852 @default.
- W4386757931 cites W1982948566 @default.
- W4386757931 cites W1997022650 @default.
- W4386757931 cites W1998802885 @default.
- W4386757931 cites W2001534544 @default.
- W4386757931 cites W2001834753 @default.
- W4386757931 cites W2002434849 @default.
- W4386757931 cites W2011433684 @default.
- W4386757931 cites W2018459966 @default.
- W4386757931 cites W2026309937 @default.
- W4386757931 cites W2028113047 @default.
- W4386757931 cites W2043848021 @default.
- W4386757931 cites W2046562480 @default.
- W4386757931 cites W2049583719 @default.
- W4386757931 cites W2061309116 @default.
- W4386757931 cites W2069863917 @default.
- W4386757931 cites W2070862761 @default.
- W4386757931 cites W2072271848 @default.
- W4386757931 cites W2078167380 @default.
- W4386757931 cites W2086575436 @default.
- W4386757931 cites W2098422745 @default.
- W4386757931 cites W2098954537 @default.
- W4386757931 cites W2099424483 @default.
- W4386757931 cites W2113594895 @default.
- W4386757931 cites W2118146937 @default.
- W4386757931 cites W2121595329 @default.
- W4386757931 cites W2123229781 @default.
- W4386757931 cites W2134197986 @default.
- W4386757931 cites W2139016287 @default.
- W4386757931 cites W2139333781 @default.
- W4386757931 cites W2141363931 @default.
- W4386757931 cites W2143153043 @default.
- W4386757931 cites W2143243643 @default.
- W4386757931 cites W2145193656 @default.
- W4386757931 cites W2146664729 @default.
- W4386757931 cites W2154963996 @default.
- W4386757931 cites W2156353972 @default.
- W4386757931 cites W2156470388 @default.
- W4386757931 cites W2162344377 @default.
- W4386757931 cites W2162766318 @default.
- W4386757931 cites W2164825249 @default.
- W4386757931 cites W2170019319 @default.
- W4386757931 cites W2184500611 @default.
- W4386757931 cites W2334639754 @default.
- W4386757931 cites W2467561455 @default.
- W4386757931 cites W2620406790 @default.
- W4386757931 cites W2769719015 @default.
- W4386757931 cites W2808045592 @default.
- W4386757931 cites W2811078818 @default.
- W4386757931 cites W2883621086 @default.
- W4386757931 cites W2887294293 @default.
- W4386757931 cites W2937552917 @default.
- W4386757931 cites W2948104235 @default.
- W4386757931 cites W2979227073 @default.
- W4386757931 cites W3029699951 @default.
- W4386757931 cites W3039622384 @default.
- W4386757931 cites W3048014252 @default.
- W4386757931 cites W3077035771 @default.
- W4386757931 cites W3081020556 @default.
- W4386757931 cites W3083024959 @default.
- W4386757931 cites W3084247070 @default.
- W4386757931 cites W3124429539 @default.
- W4386757931 cites W3133424156 @default.
- W4386757931 cites W3133678581 @default.
- W4386757931 cites W3158076751 @default.
- W4386757931 cites W3161420092 @default.
- W4386757931 cites W3189879606 @default.
- W4386757931 cites W3198478164 @default.
- W4386757931 cites W3217448455 @default.
- W4386757931 cites W4207045477 @default.
- W4386757931 cites W4220917002 @default.
- W4386757931 cites W4225278825 @default.
- W4386757931 cites W4229025661 @default.
- W4386757931 cites W4292764465 @default.
- W4386757931 cites W4293699621 @default.
- W4386757931 cites W4298087137 @default.
- W4386757931 cites W4306360087 @default.
- W4386757931 cites W4310540156 @default.
- W4386757931 cites W4312095147 @default.
- W4386757931 cites W4313621194 @default.
- W4386757931 cites W4318960207 @default.