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• W4386758051 abstract "Activated Abelson non-receptor tyrosine kinase (c-Abl) plays a harmful role in neurodegenerative conditions such as Parkinson's disease (PD). Inhibition of c-Abl is reported to have a neuroprotective effect and be a promising therapeutic strategy for PD. We have previously identified a series of benzo[d]thiazole derivatives as selective c-Abl inhibitors from which one compound showed high therapeutic potential. Herein, we report the development of a complementary positron emission tomography (PET) tracer. In total, three PET tracer candidates were developed and eventually radiolabeled with fluorine-18 for in vivo evaluation studies in mice. Candidate [18F]3 was identified as the most promising compound, since it showed sufficient brain uptake, good washout kinetics, and satisfactory metabolic stability. In conclusion, we believe this tracer provides a good starting point to further validate and explore c-Abl as a target for therapeutic strategies against PD supported by PET." @default.
• W4386758051 created "2023-09-16" @default.
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• W4386758051 date "2023-09-15" @default.
• W4386758051 modified "2023-09-30" @default.
• W4386758051 title "Development of ¹⁸F-Labeled PET Tracer Candidates for Imaging of the Abelson Non-receptor Tyrosine Kinase in Parkinson’s Disease" @default.
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• W4386758051 doi "https://doi.org/10.1021/acs.jmedchem.3c00902" @default.
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• W4386758051 hasPublicationYear "2023" @default.
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