Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386758341> ?p ?o ?g. }
- W4386758341 endingPage "2718" @default.
- W4386758341 startingPage "2709" @default.
- W4386758341 abstract "The chance of getting colorectal cancer (CRC) is higher in people with chronic ulcerative colitis (UC). The impact of parasitic infections on UC is underappreciated. The purpose of this study was to look into the effect of intestinal protozoal infections on the dysplastic changes generated by UC. The research included 152 adult patients with histologically confirmed UC and 152 healthy controls. Fecal samples were examined for the presence of parasites and fecal calprotectin (FC). The enzyme-linked immunosorbent assay measured serum anti-p53 antibodies (p53Abs) and metallothioneins (MTs). The advanced oxidation protein products (AOPPs) and reduced glutathione (GSH) levels were measured by a spectrophotometric method in all subjects. Serum C-reactive protein (CRP) and IL-6 were also measured. In addition, histopathological and immunohistochemical investigations of intestinal tissue were done. Our results exhibited significant increases in FC and CRP, IL-6, AOPPs, MTs, and p53Abs in ulcerative colitis patients with parasitic infections compared to those without parasites. In contrast, GSH levels showed a significant decrease in the same group compared with other groups. Histopathological and immunohistochemical assessments of intestinal tissue signified severe inflammation and strong expression of PD-L1 in patients with parasitic infections compared to others without parasitic infections. Our research indicated a greater frequency of intestinal protozoa in UC patients with elevated inflammatory and dysplastic biomarker levels. This suggests that these parasites may be involved in the etiology of chronic UC and the associated carcinogenetic process. This is the first report of a link between parasitic infections and dysplastic alterations in UC patients." @default.
- W4386758341 created "2023-09-16" @default.
- W4386758341 creator A5010033146 @default.
- W4386758341 creator A5023001615 @default.
- W4386758341 creator A5023085295 @default.
- W4386758341 creator A5030226365 @default.
- W4386758341 creator A5048455936 @default.
- W4386758341 creator A5050596095 @default.
- W4386758341 creator A5051378429 @default.
- W4386758341 creator A5064004396 @default.
- W4386758341 creator A5076358306 @default.
- W4386758341 creator A5091481006 @default.
- W4386758341 date "2023-09-15" @default.
- W4386758341 modified "2023-10-15" @default.
- W4386758341 title "Human protozoa infection and dysplasia in ulcerative colitis: a neglected aspect in a prominent disease" @default.
- W4386758341 cites W152975134 @default.
- W4386758341 cites W1546655977 @default.
- W4386758341 cites W1804680700 @default.
- W4386758341 cites W1926962973 @default.
- W4386758341 cites W1970196066 @default.
- W4386758341 cites W1975136503 @default.
- W4386758341 cites W1982488143 @default.
- W4386758341 cites W1992782534 @default.
- W4386758341 cites W2003680709 @default.
- W4386758341 cites W2011638139 @default.
- W4386758341 cites W2014776577 @default.
- W4386758341 cites W2018033203 @default.
- W4386758341 cites W2028083391 @default.
- W4386758341 cites W2050117238 @default.
- W4386758341 cites W2063576996 @default.
- W4386758341 cites W2068897227 @default.
- W4386758341 cites W2092908362 @default.
- W4386758341 cites W2096254377 @default.
- W4386758341 cites W2097786984 @default.
- W4386758341 cites W2100901155 @default.
- W4386758341 cites W2101911260 @default.
- W4386758341 cites W2102013054 @default.
- W4386758341 cites W2111376662 @default.
- W4386758341 cites W2135973124 @default.
- W4386758341 cites W2182109651 @default.
- W4386758341 cites W2188248802 @default.
- W4386758341 cites W2205328450 @default.
- W4386758341 cites W2271855069 @default.
- W4386758341 cites W2337314195 @default.
- W4386758341 cites W2341793727 @default.
- W4386758341 cites W2517504297 @default.
- W4386758341 cites W2560367415 @default.
- W4386758341 cites W2572174216 @default.
- W4386758341 cites W2572270369 @default.
- W4386758341 cites W2589116504 @default.
- W4386758341 cites W2730120915 @default.
- W4386758341 cites W2763141254 @default.
- W4386758341 cites W2799645368 @default.
- W4386758341 cites W2800951902 @default.
- W4386758341 cites W2901692362 @default.
- W4386758341 cites W2921524550 @default.
- W4386758341 cites W2967396668 @default.
- W4386758341 cites W2979058912 @default.
- W4386758341 cites W2981697687 @default.
- W4386758341 cites W2999636890 @default.
- W4386758341 cites W3028632805 @default.
- W4386758341 cites W3032013567 @default.
- W4386758341 cites W3036102681 @default.
- W4386758341 cites W3097156135 @default.
- W4386758341 cites W3100681619 @default.
- W4386758341 cites W3156345815 @default.
- W4386758341 cites W3157865444 @default.
- W4386758341 cites W3167178977 @default.
- W4386758341 cites W3187084586 @default.
- W4386758341 cites W3200566944 @default.
- W4386758341 cites W4211138554 @default.
- W4386758341 cites W4283080674 @default.
- W4386758341 cites W92066130 @default.
- W4386758341 doi "https://doi.org/10.1007/s00436-023-07972-7" @default.
- W4386758341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37710023" @default.
- W4386758341 hasPublicationYear "2023" @default.
- W4386758341 type Work @default.
- W4386758341 citedByCount "0" @default.
- W4386758341 crossrefType "journal-article" @default.
- W4386758341 hasAuthorship W4386758341A5010033146 @default.
- W4386758341 hasAuthorship W4386758341A5023001615 @default.
- W4386758341 hasAuthorship W4386758341A5023085295 @default.
- W4386758341 hasAuthorship W4386758341A5030226365 @default.
- W4386758341 hasAuthorship W4386758341A5048455936 @default.
- W4386758341 hasAuthorship W4386758341A5050596095 @default.
- W4386758341 hasAuthorship W4386758341A5051378429 @default.
- W4386758341 hasAuthorship W4386758341A5064004396 @default.
- W4386758341 hasAuthorship W4386758341A5076358306 @default.
- W4386758341 hasAuthorship W4386758341A5091481006 @default.
- W4386758341 hasBestOaLocation W43867583411 @default.
- W4386758341 hasConcept C121608353 @default.
- W4386758341 hasConcept C142724271 @default.
- W4386758341 hasConcept C203014093 @default.
- W4386758341 hasConcept C204232928 @default.
- W4386758341 hasConcept C2775862500 @default.
- W4386758341 hasConcept C2775894508 @default.
- W4386758341 hasConcept C2776455988 @default.
- W4386758341 hasConcept C2776914184 @default.