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• W4386759946 endingPage "105443" @default.
• W4386759946 startingPage "105443" @default.
• W4386759946 abstract "Mechanical forces generated by dynamic cellular activities play a crucial role in the morphogenesis and growth of biological tissues. While the influence of mechanics is clear, many questions arise regarding the way by which mechanical forces communicate with biological processes at the level of a confluent cell population. Some answers may be found in the development of mathematical models that are capable of describing the emerging behavior of a large population of active agents based on individualistic rules (single-cell response). In this perspective, the present work presents a continuum-scale model that can capture, in an average sense, the active mechanics and evolution of a confluent tissue with or without external mechanical constraints. For this, we conceptualize a confluent cell population (in a monolayer) as a deformable dynamic network, where a single cell can modify the topology of its neighborhood by swapping neighbors or dividing. With this description, we use concepts from statistical mechanics and the transient network theory to derive an equivalent active visco-elastic continuum model, which can recapitulate some of the salient features of the underlying network at the macroscale. Without loss of generality, the cell network is here assumed to follow well-known rules used in vertex model simulations, which are: (a) cell elasticity based on its bulk and cortical elasticity, (b) cell intercalation (or T1 transition), and (c) cell proliferation (expansion and division). We show, through examples and illustrations, that the model is able to characterize complex cross-talk between mechanical forces and biological processes, which are likely to drive the emergent growth and deformation of cell aggregates." @default.
• W4386759946 created "2023-09-16" @default.
• W4386759946 creator A5018671958 @default.
• W4386759946 creator A5055338628 @default.
• W4386759946 date "2023-12-01" @default.
• W4386759946 modified "2023-10-05" @default.
• W4386759946 title "Continuum theory for confluent cell monolayers: Interplay between cell growth, division, and intercalation" @default.
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