FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386760732> ?p ?o ?g. }

• W4386760732 endingPage "e20182" @default.
• W4386760732 startingPage "e20182" @default.
• W4386760732 abstract "Chromosomal instability (CIN) is critical for tumor evolution, yet its relationship with stemness is unclear. Here, we describe CIN as a key stress induced during tumor initiation that is uniquely tolerated by breast cancer stem cells in an activated signaling state (aCSCs). While we noted elevated CIN specifically in tumors from aCSCs, this was not intrinsic to these cells, as baseline levels were similar to non-stem cell types. This suggests that CIN is induced during tumor initiation, and that aCSCs can better tolerate this stress. Further, this increased CIN may be transient, as it was only in low-burden aCSC tumors, with levels diminishing in more established disease. Phospho-array profiling revealed specific activation of c-Jun stress signaling in aCSCs, which we hypothesized could induce genes responsible for CIN tolerance. Indeed, we identified AXL as a c-Jun dependent gene enriched in aCSCs that enhances resistance to this stress. Thus, CIN tolerance mediated by c-Jun/AXL signaling may be a defining feature of stemness, contributing to breast cancer progression." @default.
• W4386760732 created "2023-09-16" @default.
• W4386760732 creator A5000945683 @default.
• W4386760732 creator A5048259311 @default.
• W4386760732 creator A5053562855 @default.
• W4386760732 creator A5071348051 @default.
• W4386760732 creator A5091345207 @default.
• W4386760732 creator A5092875985 @default.
• W4386760732 date "2023-09-01" @default.
• W4386760732 modified "2023-10-11" @default.
• W4386760732 title "Breast cancer stem cells tolerate chromosomal instability during tumor progression via c-Jun/AXL stress signaling" @default.
• W4386760732 cites W1491979926 @default.
• W4386760732 cites W1965659632 @default.
• W4386760732 cites W2003445065 @default.
• W4386760732 cites W2015459776 @default.
• W4386760732 cites W2023427658 @default.
• W4386760732 cites W2045829974 @default.
• W4386760732 cites W2046706362 @default.
• W4386760732 cites W2092036242 @default.
• W4386760732 cites W2097862336 @default.
• W4386760732 cites W2106292881 @default.
• W4386760732 cites W2111489144 @default.
• W4386760732 cites W2112294647 @default.
• W4386760732 cites W2123879591 @default.
• W4386760732 cites W2137162822 @default.
• W4386760732 cites W2149542744 @default.
• W4386760732 cites W2151696840 @default.
• W4386760732 cites W2166311434 @default.
• W4386760732 cites W2316375349 @default.
• W4386760732 cites W2338574429 @default.
• W4386760732 cites W2547655849 @default.
• W4386760732 cites W2553952769 @default.
• W4386760732 cites W2606288173 @default.
• W4386760732 cites W2772466774 @default.
• W4386760732 cites W2783667606 @default.
• W4386760732 cites W2890850342 @default.
• W4386760732 cites W2901765034 @default.
• W4386760732 cites W2922021678 @default.
• W4386760732 cites W3092262090 @default.
• W4386760732 cites W3101555249 @default.
• W4386760732 cites W4205369986 @default.
• W4386760732 cites W4282975734 @default.
• W4386760732 doi "https://doi.org/10.1016/j.heliyon.2023.e20182" @default.
• W4386760732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37809421" @default.
• W4386760732 hasPublicationYear "2023" @default.
• W4386760732 type Work @default.
• W4386760732 citedByCount "0" @default.
• W4386760732 crossrefType "journal-article" @default.
• W4386760732 hasAuthorship W4386760732A5000945683 @default.
• W4386760732 hasAuthorship W4386760732A5048259311 @default.
• W4386760732 hasAuthorship W4386760732A5053562855 @default.
• W4386760732 hasAuthorship W4386760732A5071348051 @default.
• W4386760732 hasAuthorship W4386760732A5091345207 @default.
• W4386760732 hasAuthorship W4386760732A5092875985 @default.
• W4386760732 hasBestOaLocation W43867607321 @default.
• W4386760732 hasConcept C104317684 @default.
• W4386760732 hasConcept C121608353 @default.
• W4386760732 hasConcept C140752955 @default.
• W4386760732 hasConcept C150555746 @default.
• W4386760732 hasConcept C2778287671 @default.
• W4386760732 hasConcept C2779013556 @default.
• W4386760732 hasConcept C2779256057 @default.
• W4386760732 hasConcept C28328180 @default.
• W4386760732 hasConcept C30481170 @default.
• W4386760732 hasConcept C502942594 @default.
• W4386760732 hasConcept C530470458 @default.
• W4386760732 hasConcept C54355233 @default.
• W4386760732 hasConcept C55427017 @default.
• W4386760732 hasConcept C62478195 @default.
• W4386760732 hasConcept C71924100 @default.
• W4386760732 hasConcept C86803240 @default.
• W4386760732 hasConcept C95444343 @default.
• W4386760732 hasConceptScore W4386760732C104317684 @default.
• W4386760732 hasConceptScore W4386760732C121608353 @default.
• W4386760732 hasConceptScore W4386760732C140752955 @default.
• W4386760732 hasConceptScore W4386760732C150555746 @default.
• W4386760732 hasConceptScore W4386760732C2778287671 @default.
• W4386760732 hasConceptScore W4386760732C2779013556 @default.
• W4386760732 hasConceptScore W4386760732C2779256057 @default.
• W4386760732 hasConceptScore W4386760732C28328180 @default.
• W4386760732 hasConceptScore W4386760732C30481170 @default.
• W4386760732 hasConceptScore W4386760732C502942594 @default.
• W4386760732 hasConceptScore W4386760732C530470458 @default.
• W4386760732 hasConceptScore W4386760732C54355233 @default.
• W4386760732 hasConceptScore W4386760732C55427017 @default.
• W4386760732 hasConceptScore W4386760732C62478195 @default.
• W4386760732 hasConceptScore W4386760732C71924100 @default.
• W4386760732 hasConceptScore W4386760732C86803240 @default.
• W4386760732 hasConceptScore W4386760732C95444343 @default.
• W4386760732 hasFunder F4320308018 @default.
• W4386760732 hasFunder F4320308294 @default.
• W4386760732 hasFunder F4320321001 @default.
• W4386760732 hasIssue "9" @default.
• W4386760732 hasLocation W43867607321 @default.
• W4386760732 hasLocation W43867607322 @default.
• W4386760732 hasOpenAccess W4386760732 @default.
• W4386760732 hasPrimaryLocation W43867607321 @default.
• W4386760732 hasRelatedWork W165076036 @default.

• next