Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386761032> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4386761032 abstract "Coronavirus disease 2019 (COVID-19) vaccines are highly effective; however, vaccine-related adverse events, including autoimmunity, have been reported. Case reports describing relapse or new-onset of ulcerative colitis (UC) after COVID-19 mRNA vaccination are available. However, the molecular mechanisms underlying the development of colonic inflammation associated with COVID-19 mRNA vaccination are poorly understood. Furthermore, it is unclear whether the relapse of UC after COVID-19 vaccination is driven by unique cytokine responses that differ from those of UC not associated with vaccination. mRNAs derived from COVID-19 vaccines are potent inducers of type I IFN response. We encountered three cases of UC relapse after COVID-19 vaccination. mRNA expressions of IFN-α, IFN-β, IL-1β, and IL-12/23p40 showed higher tendency in the colonic mucosa of patients with UC associated with vaccination compared with those not associated with vaccination. In contrast, the expressions of C-X-C motif chemokine ligand 9 (CXCL9) and CXCL10 were comparable. Immunofluorescence analyses also showed higher expression of IFN-α in the colonic mucosa of patients with UC associated with COVID-19 vaccination than in those not associated with vaccination. Taken together, these data suggest that the colonic mucosa of patients with UC who relapsed after COVID-19 vaccination was characterized by enhanced type I IFN responses." @default.
- W4386761032 created "2023-09-16" @default.
- W4386761032 creator A5013243902 @default.
- W4386761032 creator A5022208166 @default.
- W4386761032 creator A5028895963 @default.
- W4386761032 creator A5032900701 @default.
- W4386761032 creator A5034851349 @default.
- W4386761032 creator A5037991300 @default.
- W4386761032 creator A5045310248 @default.
- W4386761032 creator A5049711029 @default.
- W4386761032 creator A5059453447 @default.
- W4386761032 creator A5067144826 @default.
- W4386761032 date "2023-01-01" @default.
- W4386761032 modified "2023-09-27" @default.
- W4386761032 title "Cytokine and Chemokine Profiles in Ulcerative Colitis Relapse after Coronavirus Disease 2019 Vaccination" @default.
- W4386761032 doi "https://doi.org/10.3164/jcbn.23-26" @default.
- W4386761032 hasPublicationYear "2023" @default.
- W4386761032 type Work @default.
- W4386761032 citedByCount "0" @default.
- W4386761032 crossrefType "journal-article" @default.
- W4386761032 hasAuthorship W4386761032A5013243902 @default.
- W4386761032 hasAuthorship W4386761032A5022208166 @default.
- W4386761032 hasAuthorship W4386761032A5028895963 @default.
- W4386761032 hasAuthorship W4386761032A5032900701 @default.
- W4386761032 hasAuthorship W4386761032A5034851349 @default.
- W4386761032 hasAuthorship W4386761032A5037991300 @default.
- W4386761032 hasAuthorship W4386761032A5045310248 @default.
- W4386761032 hasAuthorship W4386761032A5049711029 @default.
- W4386761032 hasAuthorship W4386761032A5059453447 @default.
- W4386761032 hasAuthorship W4386761032A5067144826 @default.
- W4386761032 hasBestOaLocation W43867610321 @default.
- W4386761032 hasConcept C126322002 @default.
- W4386761032 hasConcept C13373296 @default.
- W4386761032 hasConcept C17502307 @default.
- W4386761032 hasConcept C203014093 @default.
- W4386761032 hasConcept C22070199 @default.
- W4386761032 hasConcept C2776914184 @default.
- W4386761032 hasConcept C2778260677 @default.
- W4386761032 hasConcept C2779134260 @default.
- W4386761032 hasConcept C2780130043 @default.
- W4386761032 hasConcept C2780479503 @default.
- W4386761032 hasConcept C5858377 @default.
- W4386761032 hasConcept C71924100 @default.
- W4386761032 hasConcept C8891405 @default.
- W4386761032 hasConceptScore W4386761032C126322002 @default.
- W4386761032 hasConceptScore W4386761032C13373296 @default.
- W4386761032 hasConceptScore W4386761032C17502307 @default.
- W4386761032 hasConceptScore W4386761032C203014093 @default.
- W4386761032 hasConceptScore W4386761032C22070199 @default.
- W4386761032 hasConceptScore W4386761032C2776914184 @default.
- W4386761032 hasConceptScore W4386761032C2778260677 @default.
- W4386761032 hasConceptScore W4386761032C2779134260 @default.
- W4386761032 hasConceptScore W4386761032C2780130043 @default.
- W4386761032 hasConceptScore W4386761032C2780479503 @default.
- W4386761032 hasConceptScore W4386761032C5858377 @default.
- W4386761032 hasConceptScore W4386761032C71924100 @default.
- W4386761032 hasConceptScore W4386761032C8891405 @default.
- W4386761032 hasLocation W43867610321 @default.
- W4386761032 hasOpenAccess W4386761032 @default.
- W4386761032 hasPrimaryLocation W43867610321 @default.
- W4386761032 hasRelatedWork W2042092652 @default.
- W4386761032 hasRelatedWork W2049942503 @default.
- W4386761032 hasRelatedWork W2109220360 @default.
- W4386761032 hasRelatedWork W2143944469 @default.
- W4386761032 hasRelatedWork W2287888218 @default.
- W4386761032 hasRelatedWork W2362292339 @default.
- W4386761032 hasRelatedWork W2608377891 @default.
- W4386761032 hasRelatedWork W2765724200 @default.
- W4386761032 hasRelatedWork W2793584160 @default.
- W4386761032 hasRelatedWork W4285042906 @default.
- W4386761032 isParatext "false" @default.
- W4386761032 isRetracted "false" @default.
- W4386761032 workType "article" @default.