FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386762012> ?p ?o ?g. }

• W4386762012 endingPage "210" @default.
• W4386762012 startingPage "202" @default.
• W4386762012 abstract "Objective. To evaluate frequency of pharyngeal and rectal mucosa colonization by K. pneumoniae strains in infants with congenital heart defects at the stage of cardiosurgical hospital admission, as well as dynamic analysis of production frequency and molecular structure of K. pneumoniae carbapenemases. Materials and Methods. A total of 1445 patients with risk factors (antibiotic therapy in the anamnesis, emergency hospitalization, transfer from other hospitals) admitted for surgical treatment of congenital heart defects (CHDs) between January 1, 2020 and December 31, 2022 were included in the retrospective analysis. Median age was 1.08 months (between 0 and 12 months). Smears from the pharyngeal and rectal mucosa (2890 samples) were taken for microbiological examination no later than 72 h after admission. The isolation of extended-spectrum beta-lactamases (ESBLs) and/or carbapenemases producing K. pneumoniae in the absence of symptomatic infection was considered as colonization. K. pneumoniae strains were considered as «problematic» in the absence of susceptibility to three or more groups of antimicrobials: the third- and fourth-generation cephalosporins, carbapenems, fluoroquinolones, aminoglycosides. The profile of antibiotic resistance, carbapenemases production and their molecular type were determined in the isolated strains. Results. K. pneumoniae carriage with «problematic» sensitivity was detected in 252 out of 1445 (17.4%) patients: 153 out of 1445 (10.6%) children were colonized by only ESBLs producers, and 99 out of 1445 (6.9%) children – by both ESBLs and carbapenemases producers. In dynamics, the number of ESBLs producers carriers decreased by 1.5 times (50 out of 448 – 11.2% and 37 out of 506 – 7.3% in 2020 and 2022, respectively). The number of K. pneumoniae producing both ESBLs and carbapenemases carriers increased by 4.9 times (11 out of 448 – 2.5% and 62 out ogf 506 – 12.3% in 2020 and 2022, respectively), in 2022 exceeding the proportion of only ESBLs producers carriers by 1.7 times. The molecular structure of carbapenemases was represented by OXA-48 carbapenemases (44 out of 99 – 44.5%), NDM metalloenzymes (35 out of 99 – 35.4%), OXA-48 and NDM combinations (13 out of 99 – 13.1%), KPC (3 out of 99 – 3%), NDM, KPC and OXA-48, NDM and KPC combinations: 3 out of 99 – 3% and 1 out of 99 – 1% of carriers, respectively. In dynamics, the number of isolates with the production of OXA-48 carbapenemases increased by 34.8% (from 18.2% to 53% in 2020 and 2022, respectively), NDM carbapenemases and co-producers of OXA-48, NDM decreased by 25.9% (from 54.5% to 28.6% in 2020 and 2022) and 19.1% (from 27.3% to 8.2% in 2020 and in 2022), respectively. In 2022, strains with the production of KPC carbapenemases and co-producers of carbapenemases of three classes (OXA-48, NDM and KPC) were identified for the first time. Conclusions. The data obtained indicate an increase in the frequency of initial colonization of patients with carbapenem-resistant K. pneumoniae, an expansion of the structure of carbapenemases produced by them, that, if infection control measures are not followed, can increase the frequency of infections caused by them." @default.
• W4386762012 created "2023-09-16" @default.
• W4386762012 creator A5012585876 @default.
• W4386762012 creator A5018323357 @default.
• W4386762012 creator A5070488205 @default.
• W4386762012 date "2023-01-01" @default.
• W4386762012 modified "2023-09-27" @default.
• W4386762012 title "Carriage of K. pneumoniae and molecular structure of produced carbapenemases in infants with congenital heart defects" @default.
• W4386762012 cites W2037803049 @default.
• W4386762012 cites W2253850614 @default.
• W4386762012 cites W2538058458 @default.
• W4386762012 cites W2572137481 @default.
• W4386762012 cites W2737953146 @default.
• W4386762012 cites W2761317351 @default.
• W4386762012 cites W2761401193 @default.
• W4386762012 cites W2770896683 @default.
• W4386762012 cites W2884703500 @default.
• W4386762012 cites W2946657182 @default.
• W4386762012 cites W2980695608 @default.
• W4386762012 cites W2983920188 @default.
• W4386762012 cites W2993238637 @default.
• W4386762012 cites W3005734469 @default.
• W4386762012 cites W3034125968 @default.
• W4386762012 cites W3048460974 @default.
• W4386762012 cites W3080611838 @default.
• W4386762012 cites W3092681993 @default.
• W4386762012 cites W3175792336 @default.
• W4386762012 cites W3191952496 @default.
• W4386762012 cites W3199371163 @default.
• W4386762012 cites W3206245422 @default.
• W4386762012 cites W4200250437 @default.
• W4386762012 cites W4200364387 @default.
• W4386762012 cites W4206216653 @default.
• W4386762012 cites W4294190615 @default.
• W4386762012 cites W4298148245 @default.
• W4386762012 cites W4309437347 @default.
• W4386762012 cites W4310456893 @default.
• W4386762012 cites W4324129126 @default.
• W4386762012 cites W4362676776 @default.
• W4386762012 cites W4376643086 @default.
• W4386762012 cites W4382933829 @default.
• W4386762012 doi "https://doi.org/10.36488/cmac.2023.2.202-210" @default.
• W4386762012 hasPublicationYear "2023" @default.
• W4386762012 type Work @default.
• W4386762012 citedByCount "0" @default.
• W4386762012 crossrefType "journal-article" @default.
• W4386762012 hasAuthorship W4386762012A5012585876 @default.
• W4386762012 hasAuthorship W4386762012A5018323357 @default.
• W4386762012 hasAuthorship W4386762012A5070488205 @default.
• W4386762012 hasBestOaLocation W43867620121 @default.
• W4386762012 hasConcept C104317684 @default.
• W4386762012 hasConcept C126322002 @default.
• W4386762012 hasConcept C142724271 @default.
• W4386762012 hasConcept C145333580 @default.
• W4386762012 hasConcept C2776927270 @default.
• W4386762012 hasConcept C2777058267 @default.
• W4386762012 hasConcept C32762888 @default.
• W4386762012 hasConcept C501593827 @default.
• W4386762012 hasConcept C547475151 @default.
• W4386762012 hasConcept C55493867 @default.
• W4386762012 hasConcept C64778159 @default.
• W4386762012 hasConcept C71924100 @default.
• W4386762012 hasConcept C86803240 @default.
• W4386762012 hasConcept C89423630 @default.
• W4386762012 hasConcept C90924648 @default.
• W4386762012 hasConceptScore W4386762012C104317684 @default.
• W4386762012 hasConceptScore W4386762012C126322002 @default.
• W4386762012 hasConceptScore W4386762012C142724271 @default.
• W4386762012 hasConceptScore W4386762012C145333580 @default.
• W4386762012 hasConceptScore W4386762012C2776927270 @default.
• W4386762012 hasConceptScore W4386762012C2777058267 @default.
• W4386762012 hasConceptScore W4386762012C32762888 @default.
• W4386762012 hasConceptScore W4386762012C501593827 @default.
• W4386762012 hasConceptScore W4386762012C547475151 @default.
• W4386762012 hasConceptScore W4386762012C55493867 @default.
• W4386762012 hasConceptScore W4386762012C64778159 @default.
• W4386762012 hasConceptScore W4386762012C71924100 @default.
• W4386762012 hasConceptScore W4386762012C86803240 @default.
• W4386762012 hasConceptScore W4386762012C89423630 @default.
• W4386762012 hasConceptScore W4386762012C90924648 @default.
• W4386762012 hasIssue "2" @default.
• W4386762012 hasLocation W43867620121 @default.
• W4386762012 hasOpenAccess W4386762012 @default.
• W4386762012 hasPrimaryLocation W43867620121 @default.
• W4386762012 hasRelatedWork W1498425723 @default.
• W4386762012 hasRelatedWork W2137461060 @default.
• W4386762012 hasRelatedWork W2171447404 @default.
• W4386762012 hasRelatedWork W2392606755 @default.
• W4386762012 hasRelatedWork W2410397869 @default.
• W4386762012 hasRelatedWork W2437887930 @default.
• W4386762012 hasRelatedWork W2981555645 @default.
• W4386762012 hasRelatedWork W3201776833 @default.
• W4386762012 hasRelatedWork W4284710444 @default.
• W4386762012 hasRelatedWork W2141453651 @default.
• W4386762012 hasVolume "25" @default.
• W4386762012 isParatext "false" @default.
• W4386762012 isRetracted "false" @default.
• W4386762012 workType "article" @default.