FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386762904> ?p ?o ?g. }

• W4386762904 abstract "Changes to our environment have led to the emergence of human pathogens such as chikungunya virus. Chikungunya virus infection is today a major public health concern. It is a debilitating chronic disease impeding patients' mobility, affecting millions of people. Disease development relies on skeletal muscle infection. The importance of skeletal muscle in chikungunya virus infection led to the hypothesis that it could serve as a viral reservoir and could participate to virus persistence. Here we questioned the interconnection between skeletal muscle cells metabolism, their differentiation stage and the infectivity of the chikungunya virus. We infected human skeletal muscle stem cells at different stages of differentiation with chikungunya virus to study the impact of their metabolism on virus production and inversely the impact of virus on cell metabolism. We observed that chikungunya virus infectivity is cell differentiation and metabolism-dependent. Chikungunya virus interferes with the cellular metabolism in quiescent undifferentiated and proliferative muscle cells. Moreover, activation of chikungunya infected quiescent muscle stem cells, induces their proliferation, increases glycolysis and amplifies virus production. Therefore, our results showed that Chikungunya virus infectivity and the antiviral response of skeletal muscle cells relies on their energetic metabolism and their differentiation stage. Then, muscle stem cells could serve as viral reservoir producing virus after their activation." @default.
• W4386762904 created "2023-09-16" @default.
• W4386762904 creator A5009411690 @default.
• W4386762904 creator A5019775022 @default.
• W4386762904 creator A5060771305 @default.
• W4386762904 creator A5068395602 @default.
• W4386762904 creator A5073219925 @default.
• W4386762904 creator A5090272472 @default.
• W4386762904 date "2023-09-01" @default.
• W4386762904 modified "2023-10-18" @default.
• W4386762904 title "Human muscle cells sensitivity to chikungunya virus infection relies on their glycolysis activity and differentiation stage" @default.
• W4386762904 cites W1536070820 @default.
• W4386762904 cites W1607273785 @default.
• W4386762904 cites W1917542302 @default.
• W4386762904 cites W1969878494 @default.
• W4386762904 cites W1977312265 @default.
• W4386762904 cites W1978422731 @default.
• W4386762904 cites W1981582579 @default.
• W4386762904 cites W1996617753 @default.
• W4386762904 cites W2009692743 @default.
• W4386762904 cites W2010760600 @default.
• W4386762904 cites W2012991731 @default.
• W4386762904 cites W2016856144 @default.
• W4386762904 cites W2017714954 @default.
• W4386762904 cites W2022342738 @default.
• W4386762904 cites W2047500501 @default.
• W4386762904 cites W2047581693 @default.
• W4386762904 cites W2051512444 @default.
• W4386762904 cites W2064602529 @default.
• W4386762904 cites W2070608209 @default.
• W4386762904 cites W2072809212 @default.
• W4386762904 cites W2078944084 @default.
• W4386762904 cites W2087803244 @default.
• W4386762904 cites W2089479234 @default.
• W4386762904 cites W2090448309 @default.
• W4386762904 cites W2095987251 @default.
• W4386762904 cites W2133943332 @default.
• W4386762904 cites W2139352935 @default.
• W4386762904 cites W2141987735 @default.
• W4386762904 cites W2144486439 @default.
• W4386762904 cites W2169401893 @default.
• W4386762904 cites W2170869159 @default.
• W4386762904 cites W2191075961 @default.
• W4386762904 cites W2227929566 @default.
• W4386762904 cites W2344838470 @default.
• W4386762904 cites W2403240391 @default.
• W4386762904 cites W2562868114 @default.
• W4386762904 cites W2591784983 @default.
• W4386762904 cites W2594220414 @default.
• W4386762904 cites W2622995208 @default.
• W4386762904 cites W2623679270 @default.
• W4386762904 cites W2750861136 @default.
• W4386762904 cites W2781056930 @default.
• W4386762904 cites W2789637958 @default.
• W4386762904 cites W2789926851 @default.
• W4386762904 cites W2793701587 @default.
• W4386762904 cites W2810661705 @default.
• W4386762904 cites W2914471127 @default.
• W4386762904 cites W2930933038 @default.
• W4386762904 cites W2939431454 @default.
• W4386762904 cites W2947020562 @default.
• W4386762904 cites W2963643276 @default.
• W4386762904 cites W2967714070 @default.
• W4386762904 cites W2977027474 @default.
• W4386762904 cites W2994057239 @default.
• W4386762904 cites W3033213610 @default.
• W4386762904 cites W3094593610 @default.
• W4386762904 cites W3188966859 @default.
• W4386762904 cites W3197718606 @default.
• W4386762904 cites W3199701791 @default.
• W4386762904 cites W3206038694 @default.
• W4386762904 cites W3207928698 @default.
• W4386762904 cites W4221079750 @default.
• W4386762904 cites W4309094521 @default.
• W4386762904 doi "https://doi.org/10.1016/j.biochi.2023.09.005" @default.
• W4386762904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37716499" @default.
• W4386762904 hasPublicationYear "2023" @default.
• W4386762904 type Work @default.
• W4386762904 citedByCount "0" @default.
• W4386762904 crossrefType "journal-article" @default.
• W4386762904 hasAuthorship W4386762904A5009411690 @default.
• W4386762904 hasAuthorship W4386762904A5019775022 @default.
• W4386762904 hasAuthorship W4386762904A5060771305 @default.
• W4386762904 hasAuthorship W4386762904A5068395602 @default.
• W4386762904 hasAuthorship W4386762904A5073219925 @default.
• W4386762904 hasAuthorship W4386762904A5090272472 @default.
• W4386762904 hasConcept C106358424 @default.
• W4386762904 hasConcept C134018914 @default.
• W4386762904 hasConcept C159047783 @default.
• W4386762904 hasConcept C2522874641 @default.
• W4386762904 hasConcept C2779959927 @default.
• W4386762904 hasConcept C2781273456 @default.
• W4386762904 hasConcept C2781313946 @default.
• W4386762904 hasConcept C86803240 @default.
• W4386762904 hasConceptScore W4386762904C106358424 @default.
• W4386762904 hasConceptScore W4386762904C134018914 @default.
• W4386762904 hasConceptScore W4386762904C159047783 @default.
• W4386762904 hasConceptScore W4386762904C2522874641 @default.
• W4386762904 hasConceptScore W4386762904C2779959927 @default.
• W4386762904 hasConceptScore W4386762904C2781273456 @default.

• next