Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386764959> ?p ?o ?g. }
- W4386764959 abstract "Abstract Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report that loss of melanocortin-1 receptor (MC1R) in melanoma cells activates antitumor T cell response and overcomes resistance to ICB. Depletion of MC1R from another melanocytic melanoma model HCmel1274 also enhances ICB efficacy. By activating the GNAS-PKA axis, MC1R inhibits interferon-gamma induced CXCL9 / 10 / 11 transcription, thus impairing T cell infiltration into the tumor microenvironment. In human melanomas, high MC1R expression correlates with reduced CXCL9 / 10 / 11 expression, impaired T cell infiltration, and poor patient prognosis. Whereas MC1R activation is restricted to melanoma, GNAS activation by hotspot mutations is observed across diverse cancer types and is associated with reduced CXCL9 / 10 / 11 expression. Our study implicates MC1R as a melanoma immunotherapy target and suggests GNAS-PKA signaling as a pan-cancer oncogenic pathway inhibiting antitumor T cell response." @default.
- W4386764959 created "2023-09-16" @default.
- W4386764959 creator A5026771248 @default.
- W4386764959 creator A5027737198 @default.
- W4386764959 creator A5028935321 @default.
- W4386764959 creator A5032768745 @default.
- W4386764959 creator A5035258724 @default.
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- W4386764959 creator A5058171128 @default.
- W4386764959 creator A5067674354 @default.
- W4386764959 creator A5085356073 @default.
- W4386764959 date "2023-09-15" @default.
- W4386764959 modified "2023-09-29" @default.
- W4386764959 title "Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity" @default.
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