Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386766475> ?p ?o ?g. }
- W4386766475 abstract "Cancers feature substantial intratumoral heterogeneity of genetic and phenotypically distinct lineages. Although interactions between coexisting lineages are emerging as a potential contributor to tumor evolution, the extent and nature of these interactions remain largely unknown. We postulated that tumors develop ecological interactions that sustain diversity and facilitate metastasis. Using a combination of fluorescent barcoding, mathematical modeling, metabolic analysis, and in vivo models, we show that the Allee effect, i.e., growth dependency on population size, is a feature of tumor lineages and that cooperative ecological interactions between lineages alleviate the Allee barriers to growth in a model of triple-negative breast cancer. Soluble metabolite exchange formed the basis for these cooperative interactions and catalyzed the establishment of a polyclonal community that displayed enhanced metastatic dissemination and outgrowth in xenograft models. Our results highlight interclonal metabolite exchange as a key modulator of tumor ecology and a contributing factor to overcoming Allee effect-associated growth barriers to metastasis." @default.
- W4386766475 created "2023-09-16" @default.
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- W4386766475 date "2023-09-15" @default.
- W4386766475 modified "2023-09-27" @default.
- W4386766475 title "Clonal cooperation through soluble metabolite exchange facilitates metastatic outgrowth by modulating Allee effect" @default.
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- W4386766475 doi "https://doi.org/10.1126/sciadv.adh4184" @default.
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