Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386768898> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4386768898 endingPage "13" @default.
- W4386768898 startingPage "1" @default.
- W4386768898 abstract "Polysaccharide hydrogel is one of the most important materials for the colon target drug release system. However, the degradation time of polysaccharide hydrogel is much longer than the retention time in the colon. The drugs are expelled from the body before being released.In order to match the degradation of drug carriers and their retention time in the colon, a rapidly degradable konjac glucomannan (KGM) hydrogel was designed for colon target drug release.A crosslinker containing azo bond, olsalazine, was used to prepare the rapidly degradable KGM hydrogel. The degradation and drug release of the hydrogels with different crosslinking densities in the normal buffer and the human fecal medium were studied to evaluate the efficiency of colon drug release.More than 50% of the KGM hydrogel by weight was degraded and more than 60% of the 5-fluorouracil (5-Fu) was released within 48 h in 5% w/v human fecal medium.The drug was released more rapidly in a simulated colon environment than in a normal buffer. Furthermore, the drug release was controlled by the degradation of the hydrogel. The KGM hydrogel containing azo crosslinker has great potential for colon drug release." @default.
- W4386768898 created "2023-09-16" @default.
- W4386768898 creator A5006919426 @default.
- W4386768898 creator A5008384374 @default.
- W4386768898 creator A5024741363 @default.
- W4386768898 creator A5050730188 @default.
- W4386768898 creator A5064564309 @default.
- W4386768898 date "2023-09-13" @default.
- W4386768898 modified "2023-10-01" @default.
- W4386768898 title "Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release" @default.
- W4386768898 cites W1995975815 @default.
- W4386768898 cites W2036741510 @default.
- W4386768898 cites W2043869451 @default.
- W4386768898 cites W2049134184 @default.
- W4386768898 cites W2055355486 @default.
- W4386768898 cites W2091982720 @default.
- W4386768898 cites W2112981618 @default.
- W4386768898 cites W2131698002 @default.
- W4386768898 cites W2284960947 @default.
- W4386768898 cites W2300123552 @default.
- W4386768898 cites W2472537166 @default.
- W4386768898 cites W2511571118 @default.
- W4386768898 cites W2558800386 @default.
- W4386768898 cites W2790379695 @default.
- W4386768898 cites W2898029579 @default.
- W4386768898 cites W2932536921 @default.
- W4386768898 cites W2954117295 @default.
- W4386768898 cites W2969470035 @default.
- W4386768898 cites W3157838070 @default.
- W4386768898 cites W3159766971 @default.
- W4386768898 cites W4200233730 @default.
- W4386768898 cites W4285404203 @default.
- W4386768898 cites W4308445212 @default.
- W4386768898 cites W620044983 @default.
- W4386768898 doi "https://doi.org/10.3233/bme-230066" @default.
- W4386768898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37718772" @default.
- W4386768898 hasPublicationYear "2023" @default.
- W4386768898 type Work @default.
- W4386768898 citedByCount "0" @default.
- W4386768898 crossrefType "journal-article" @default.
- W4386768898 hasAuthorship W4386768898A5006919426 @default.
- W4386768898 hasAuthorship W4386768898A5008384374 @default.
- W4386768898 hasAuthorship W4386768898A5024741363 @default.
- W4386768898 hasAuthorship W4386768898A5050730188 @default.
- W4386768898 hasAuthorship W4386768898A5064564309 @default.
- W4386768898 hasConcept C100817775 @default.
- W4386768898 hasConcept C108586683 @default.
- W4386768898 hasConcept C13245373 @default.
- W4386768898 hasConcept C163588942 @default.
- W4386768898 hasConcept C178790620 @default.
- W4386768898 hasConcept C185592680 @default.
- W4386768898 hasConcept C188027245 @default.
- W4386768898 hasConcept C2779679103 @default.
- W4386768898 hasConcept C2779820397 @default.
- W4386768898 hasConcept C2780035454 @default.
- W4386768898 hasConcept C41008148 @default.
- W4386768898 hasConcept C43617362 @default.
- W4386768898 hasConcept C55493867 @default.
- W4386768898 hasConcept C71924100 @default.
- W4386768898 hasConcept C76155785 @default.
- W4386768898 hasConcept C98274493 @default.
- W4386768898 hasConceptScore W4386768898C100817775 @default.
- W4386768898 hasConceptScore W4386768898C108586683 @default.
- W4386768898 hasConceptScore W4386768898C13245373 @default.
- W4386768898 hasConceptScore W4386768898C163588942 @default.
- W4386768898 hasConceptScore W4386768898C178790620 @default.
- W4386768898 hasConceptScore W4386768898C185592680 @default.
- W4386768898 hasConceptScore W4386768898C188027245 @default.
- W4386768898 hasConceptScore W4386768898C2779679103 @default.
- W4386768898 hasConceptScore W4386768898C2779820397 @default.
- W4386768898 hasConceptScore W4386768898C2780035454 @default.
- W4386768898 hasConceptScore W4386768898C41008148 @default.
- W4386768898 hasConceptScore W4386768898C43617362 @default.
- W4386768898 hasConceptScore W4386768898C55493867 @default.
- W4386768898 hasConceptScore W4386768898C71924100 @default.
- W4386768898 hasConceptScore W4386768898C76155785 @default.
- W4386768898 hasConceptScore W4386768898C98274493 @default.
- W4386768898 hasLocation W43867688981 @default.
- W4386768898 hasLocation W43867688982 @default.
- W4386768898 hasOpenAccess W4386768898 @default.
- W4386768898 hasPrimaryLocation W43867688981 @default.
- W4386768898 hasRelatedWork W2048829256 @default.
- W4386768898 hasRelatedWork W2317856560 @default.
- W4386768898 hasRelatedWork W2340623326 @default.
- W4386768898 hasRelatedWork W2555045441 @default.
- W4386768898 hasRelatedWork W2591960472 @default.
- W4386768898 hasRelatedWork W2997083311 @default.
- W4386768898 hasRelatedWork W3131650548 @default.
- W4386768898 hasRelatedWork W4220776040 @default.
- W4386768898 hasRelatedWork W4366089454 @default.
- W4386768898 hasRelatedWork W4386099080 @default.
- W4386768898 isParatext "false" @default.
- W4386768898 isRetracted "false" @default.
- W4386768898 workType "article" @default.