Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386769869> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- W4386769869 abstract "Natural experience often involves a continuous series of related images while the subject is immobile. How does the cortico-hippocampal circuit process this information? The hippocampus is crucial for episodic memory–, but most rodent single unit studies require spatial exploration– or active engagement7. Hence, we investigated neural responses to a silent, isoluminant, black and white movie in head-fixed mice without any task or locomotion demands, or rewards, from the Allen Brain Observatory. The activity of most neurons (97%, 6554/6785) in the thalamo-cortical visual areas was significantly modulated by the 30s long movie clip. Surprisingly, a third (33%, 3379/10263) of hippocampal –dentate gyrus, CA1 and subiculum– neurons showed movie-selectivity, with elevated firing in specific movie sub-segments, termed movie-fields. Movie-tuning remained intact when mice were immobile or ran spontaneously. On average, a tuned cell had more than 5 movie-fields in visual areas, but only 2 in hippocampal areas. The movie-field durations in all brain regions spanned an unprecedented 1000-fold range: from 0.02s to 20s, termed mega-scale coding. Yet, the total duration of all the movie-fields of a cell was comparable across neurons and brain regions. We hypothesize that hippocampal responses show greater continuous-sequence encoding than visual areas, as evidenced by fewer and broader movie-fields than in visual areas. Consistent with this hypothesis, repeated presentation of the movie images in a fixed, scrambled sequence virtually abolished hippocampal but not visual-cortical selectivity. The enhancement of continuous movie tuning compared to the scrambled sequence was eight-fold greater in hippocampal than visual areas, further supporting episodic-sequence encoding. Thus, all mouse-brain areas investigated encoded segments of the movie. Similar results are likely to hold in primates and humans. Hence, movies could provide a unified way to probe neural mechanisms of episodic information processing and memory, even in immobile subjects, across brain regions, and species." @default.
- W4386769869 created "2023-09-16" @default.
- W4386769869 date "2023-09-15" @default.
- W4386769869 modified "2023-09-26" @default.
- W4386769869 title "Reviewer #1 (Public Review): Mega-scale movie-fields in the mouse visuo-hippocampal network" @default.
- W4386769869 doi "https://doi.org/10.7554/elife.85069.2.sa1" @default.
- W4386769869 hasPublicationYear "2023" @default.
- W4386769869 type Work @default.
- W4386769869 citedByCount "0" @default.
- W4386769869 crossrefType "peer-review" @default.
- W4386769869 hasBestOaLocation W43867698691 @default.
- W4386769869 hasConcept C148762608 @default.
- W4386769869 hasConcept C15744967 @default.
- W4386769869 hasConcept C169760540 @default.
- W4386769869 hasConcept C2776464000 @default.
- W4386769869 hasConcept C2778499278 @default.
- W4386769869 hasConcept C2781161787 @default.
- W4386769869 hasConceptScore W4386769869C148762608 @default.
- W4386769869 hasConceptScore W4386769869C15744967 @default.
- W4386769869 hasConceptScore W4386769869C169760540 @default.
- W4386769869 hasConceptScore W4386769869C2776464000 @default.
- W4386769869 hasConceptScore W4386769869C2778499278 @default.
- W4386769869 hasConceptScore W4386769869C2781161787 @default.
- W4386769869 hasLocation W43867698691 @default.
- W4386769869 hasOpenAccess W4386769869 @default.
- W4386769869 hasPrimaryLocation W43867698691 @default.
- W4386769869 hasRelatedWork W1769572743 @default.
- W4386769869 hasRelatedWork W1995681526 @default.
- W4386769869 hasRelatedWork W2056718498 @default.
- W4386769869 hasRelatedWork W2081792644 @default.
- W4386769869 hasRelatedWork W2082455255 @default.
- W4386769869 hasRelatedWork W2110836796 @default.
- W4386769869 hasRelatedWork W2506904724 @default.
- W4386769869 hasRelatedWork W3022859466 @default.
- W4386769869 hasRelatedWork W4233269494 @default.
- W4386769869 hasRelatedWork W4234750095 @default.
- W4386769869 isParatext "false" @default.
- W4386769869 isRetracted "false" @default.
- W4386769869 workType "peer-review" @default.