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- W4386770679 abstract "This chapter analyzes the common feature of T-cells and a special set of molecules known as major histocompatibility complex (MHC) proteins. The chapter studies the major distinction of T-cells between cytotoxic and helper cells. The T-cell receptor, or TCR, cannot be discussed without also discussing MHC molecules. The chapter then demonstrates how TCR and MHC act together in protein recognition. The chapter also emphasizes the CD1 molecules when presenting non-protein molecules, then expounds the meaning of MHC in more detail. Next, the chapter investigates how to convert an intracellular virus or other pathogen into a series of small peptides in the groove of the MHC molecules on the cell surface. These take place in the antigen-presenting cells (APCs), which may be dendritic cells (the most important for activating resting T-cells), macrophages, or B lymphocytes. The chapter then considers superantigens, γδ T-cells, and NKT-cells." @default.
- W4386770679 created "2023-09-16" @default.
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- W4386770679 date "2013-01-24" @default.
- W4386770679 modified "2023-09-27" @default.
- W4386770679 title "T cells and the MHC" @default.
- W4386770679 doi "https://doi.org/10.1093/hesc/9780199609505.003.0020" @default.
- W4386770679 hasPublicationYear "2013" @default.
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