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- W4386772017 abstract "This chapter defines thromboxane A<sub>2</sub> as a naturally occurring substance that has the undesirable effects of bronchoconstriction, aggregation of the blood platelets, and constriction of the blood vessels whenever it is released in the body. The inhibition of the effects of thromboxane A2 could lead to a potential treatment for circulatory or respiratory disorders. The chapter discusses a series of thromboxane antagonists that have been developed in ICI. These have similar structures to thromboxane A<sub>2</sub> and are therefore able to block the relevant receptor site in the body. The chapter highlights that the synthetic challenge for a compound to be viable as a pharmaceutical agent is achieving stereochemical control using methods that can be operated on a larger scale. The chapter covers different compounds that were synthesized in small quantities using a route that enabled the synthesis of many analogues for biological evaluation." @default.
- W4386772017 created "2023-09-16" @default.
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- W4386772017 date "1995-07-20" @default.
- W4386772017 modified "2023-09-27" @default.
- W4386772017 title "Thromboxane antagonists" @default.
- W4386772017 doi "https://doi.org/10.1093/hesc/9780198558248.003.0005" @default.
- W4386772017 hasPublicationYear "1995" @default.
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